Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow IL6R alpha  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • 12-Lipoxygenase (LOX-12) ELISA Kit
 • Transient Receptor Potential Cation Channel Subfamily V, Mem... ELISA Kit
 • B-cell lymphoma 3 protein (BCL3) Recombinant Protein
 • Neuronal Specific Enolase (NSE) Antibody
 • Thromboglobulin, Beta (bTG) ELISA Kit
 • Galectin-3BP PicoKine (LGALS3BP) ELISA Kit
 • Sn1-specific diacylglycerol lipase beta (Daglb) Recombinant Protein
 • Azidothymidine (AZT) ELISA Kit
 • EP300 - p300 Antibody
 • Bcl-2 Assaciated X protein, BAX ELISA Kit
 • CD8 Antibody
 • matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 9... ELISA Kit
 • MDH1 Recombinant Protein
 • Ferritin Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

IL6R alpha recombinant protein

Scan QR to view Datasheet Catalog #    MBS538133 IL6R alpha recombinant protein
Unit / Price
0.005 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL6R alpha, Recombinant Protein

★Popular Item★
 Also Known As   

IL6R alpha protein

 Product Synonym Names    B cell stimulatory factor-2 protein; soluble IL-6 receptor alpha protein; IL-6; IL6; Interleukin 6R alpha protein; CD126 protein; IL-6R alpha protein; IL-6 protein; IL 6 protein; IL 6
 Product Gene Name   

IL6R alpha recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    Region of IL6R protein correspond ing to amino acids LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD.
 OMIM    147880
 3D Structure    ModBase 3D Structure for P08887
Section Bar
 Host    Human
Section Bar
 Purity/Purification    > 98% pure
 Form/Format    Lyophilized from 1x PBS. Reconstitute in 1X PBS to a concentration of 0.1-1.0 mg/ml. When dissolved, dilute further into aqueous buffered solutions.
 Concentration    5ug per vial (lot specific)
Section Bar
 Protein Type    Recombinant
 Biological Significance    IL6 mediates its biological effects through the type I IL6 receptor system that consists of two chains, IL6Ra and gp130. The IL6Ra chain is the binding component specific to IL6; while the gp130 only transmits signals of IL6 when bound to IL6Ra. The gp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL6 is composed of IL6Ra alone. IL6Ra is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL6Ra which consists of only the extracellular domain of the IL6Ra chain, acts as an agonist of IL6 activity at low concentrations.
 Bioactivity    The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is approximately 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    HEK cells
Section Bar
 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IL6R alpha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for IL6R alpha recombinant protein

   Purified recombinant Human IL6R alpha protein
 Product Categories/Family for IL6R alpha recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for IL6R alpha recombinant protein   

User optimized

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for IL6R alpha. It may not necessarily be applicable to this product.
 NCBI GI #    332309226
 NCBI GeneID    3570
 NCBI Accession #    NP_001193795.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206866.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P08887 [Other Products]
 UniProt Secondary Accession #    Q16202; Q53EQ7; Q5FWG2; Q5VZ23; A8KAE8; B2R6V4 [Other Products]
 UniProt Related Accession #    P08887 [Other Products]
 Molecular Weight    37.6 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    interleukin-6 receptor subunit alpha isoform 3
 NCBI Official Synonym Full Names    interleukin 6 receptor
 NCBI Official Symbol    IL6R [Similar Products]
 NCBI Official Synonym Symbols   
IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1
[Similar Products]
 NCBI Protein Information    interleukin-6 receptor subunit alpha
 UniProt Protein Name    Interleukin-6 receptor subunit alpha
 UniProt Synonym Protein Names   
IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126
 UniProt Gene Name    IL6R [Similar Products]
 UniProt Synonym Gene Names    IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80 [Similar Products]
 UniProt Entry Name    IL6RA_HUMAN
Section Bar
 NCBI Summary for IL6R alpha    This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
Section Bar
 UniProt Comments for IL6R alpha    IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; extracellular region; interleukin-6 receptor complex

Molecular Function: protein binding; protein homodimerization activity; enzyme binding; interleukin-6 binding; interleukin-6 receptor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity

Biological Process: positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; negative regulation of collagen biosynthetic process; neutrophil mediated immunity; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; defense response to Gram-negative bacterium; endocrine pancreas development; positive regulation of chemokine production; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; monocyte chemotaxis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; negative regulation of interleukin-8 production; acute-phase response; hepatic immune response

Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus
Table BarTOPTable Bar
 Research Articles on IL6R alpha    1. Describe a novel cell-based screening assay for identifying small molecule IL-6R antagonists.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with IL6R alpha recombinant proteinPathways associated with IL6R alpha recombinant protein
 Reference Product  PubMed Publications
 IL6 recombinant protein  >123 publications with IL6R alpha and IL6
 STAT3 recombinant protein  >38 publications with IL6R alpha and STAT3
 IL6ST recombinant protein  >20 publications with IL6R alpha and IL6ST
 JAK1 recombinant protein  >4 publications with IL6R alpha and JAK1
 SOCS3 recombinant protein  >3 publications with IL6R alpha and SOCS3
 STAT1 recombinant protein  >3 publications with IL6R alpha and STAT1
 JAK2 recombinant protein  >3 publications with IL6R alpha and JAK2
 CNTF recombinant protein  >1 publications with IL6R alpha and CNTF
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
Diseases associated with IL6R alpha recombinant proteinOrgans/Tissues associated with IL6R alpha recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >102 publications with IL6R alpha and Inflammation
 Cardiovascular Diseases Antibodies  >49 publications with IL6R alpha and Cardiovascular Diseases
 Arthritis, Rheumatoid Antibodies  >38 publications with IL6R alpha and Arthritis, Rheumatoid
 Necrosis Antibodies  >35 publications with IL6R alpha and Necrosis
 Heart Diseases Antibodies  >28 publications with IL6R alpha and Heart Diseases
 Nervous System Diseases Antibodies  >16 publications with IL6R alpha and Nervous System Diseases
 Disease Models, Animal Antibodies  >15 publications with IL6R alpha and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >10 publications with IL6R alpha and Carcinoma, Hepatocellular
 Hematologic Diseases Antibodies  >9 publications with IL6R alpha and Hematologic Diseases
 Liver Neoplasms Antibodies  >8 publications with IL6R alpha and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >116 publications with IL6R alpha and Blood
 Heart Antibodies  >36 publications with IL6R alpha and Heart
 Vascular Antibodies  >25 publications with IL6R alpha and Vascular
 Liver Antibodies  >17 publications with IL6R alpha and Liver
 Lung Antibodies  >17 publications with IL6R alpha and Lung
 Bone Antibodies  >15 publications with IL6R alpha and Bone
 Kidney Antibodies  >11 publications with IL6R alpha and Kidney
 Muscle Antibodies  >10 publications with IL6R alpha and Muscle
 Brain Antibodies  >10 publications with IL6R alpha and Brain
 Bone Marrow Antibodies  >5 publications with IL6R alpha and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions