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ILGFBP1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538329 ILGFBP1 recombinant protein
Unit / Price
0.002 mg  /  $370 +1 FREE 8GB USB
0.01 mg  /  $980 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ILGFBP1, Recombinant Protein

 Also Known As   

ILGFBP1 protein

 Product Synonym Names    ILGFBP-1; hIGFBP-1 protein; PP12 protein; ILGFBP1; ILGFBP 1; ILGFBP-1 protein; AFBP protein; ILGFBP 1 protein; IGF-BP25 protein; IGF-Binding Protein 1 protein; IBP-1 protein; IGFBP-1 protein; Insulin Like Growth Factor Binding Protein 1 protein
 Product Gene Name   

ILGFBP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146730
 3D Structure    ModBase 3D Structure for P08833
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder. Reconstitute in 20mM CH3COOH at the stock concentration of not less than 0.1mg/ml.
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 Protein Type    Recombinant
 Biological Significance    IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
 Bioactivity    Inhibition of IGF-I stimulated proliferation of NUC-1 cells: IC50 ~ 100 ng/ml Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures: IC50 (1% serum) ~300 ng/ml.
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of ILGFBP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ILGFBP1 recombinant protein

   Purified recombinant Human ILGFBP1 protein
 Product Categories/Family for ILGFBP1 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for ILGFBP1 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ILGFBP1. It may not necessarily be applicable to this product.
 NCBI GI #    4504615
 NCBI GeneID    3484
 NCBI Accession #    NP_000587.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000596.2 [Other Products]
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 UniProt Primary Accession #    P08833 [Other Products]
 UniProt Secondary Accession #    Q8IYP5; A4D2F4; D3DVL9 [Other Products]
 UniProt Related Accession #    P08833 [Other Products]
 Molecular Weight    25.3 kDa
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 NCBI Official Full Name    insulin-like growth factor-binding protein 1
 NCBI Official Synonym Full Names    insulin-like growth factor binding protein 1
 NCBI Official Symbol    IGFBP1 [Similar Products]
 NCBI Official Synonym Symbols   
AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 1
 UniProt Protein Name    Insulin-like growth factor-binding protein 1
 UniProt Synonym Protein Names   
Placental protein 12; PP12
 UniProt Gene Name    IGFBP1 [Similar Products]
 UniProt Synonym Gene Names    IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12 [Similar Products]
 UniProt Entry Name    IBP1_HUMAN
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 NCBI Summary for ILGFBP1    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ILGFBP1    IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of insulin-like growth factor receptor signaling pathway; unfolded protein response; tissue regeneration; insulin receptor signaling pathway; signal transduction; positive regulation of cell growth
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 Research Articles on ILGFBP1    1. Suggest that IGFBP-1 inhibits the invasion and metastasis of HCC cells and that IGFBP-1 may be useful as a valuable marker for the prognosis of patients with HCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ILGFBP1 recombinant proteinPathways associated with ILGFBP1 recombinant protein
 Reference Product  PubMed Publications
 IGFBP4 recombinant protein  >150 publications with ILGFBP1 and IGFBP4
 IGF1 recombinant protein  >80 publications with ILGFBP1 and IGF1
 FOXO1 recombinant protein  >41 publications with ILGFBP1 and FOXO1
 IGF2 recombinant protein  >37 publications with ILGFBP1 and IGF2
 FOXA2 recombinant protein  >8 publications with ILGFBP1 and FOXA2
 INS recombinant protein  >8 publications with ILGFBP1 and INS
 ATF4 recombinant protein  >3 publications with ILGFBP1 and ATF4
 HIF1A recombinant protein  >3 publications with ILGFBP1 and HIF1A
 GCG recombinant protein  >1 publications with ILGFBP1 and GCG
 NR3C1 recombinant protein  >1 publications with ILGFBP1 and NR3C1
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 PERK Regulates Gene Expression Pathway antibodies  PERK Regulates Gene Expression Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
Diseases associated with ILGFBP1 recombinant proteinOrgans/Tissues associated with ILGFBP1 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >132 publications with ILGFBP1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >126 publications with ILGFBP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >92 publications with ILGFBP1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >87 publications with ILGFBP1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >83 publications with ILGFBP1 and Liver Neoplasms
 Kidney Diseases Antibodies  >83 publications with ILGFBP1 and Kidney Diseases
 Inflammation Antibodies  >66 publications with ILGFBP1 and Inflammation
 Necrosis Antibodies  >65 publications with ILGFBP1 and Necrosis
 Hyperglycemia Antibodies  >57 publications with ILGFBP1 and Hyperglycemia
 Carcinoma, Hepatocellular Antibodies  >55 publications with ILGFBP1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1345 publications with ILGFBP1 and Blood
 Liver Antibodies  >459 publications with ILGFBP1 and Liver
 Uterus Antibodies  >334 publications with ILGFBP1 and Uterus
 Placenta Antibodies  >242 publications with ILGFBP1 and Placenta
 Embryonic Tissue Antibodies  >132 publications with ILGFBP1 and Embryonic Tissue
 Bone Antibodies  >99 publications with ILGFBP1 and Bone
 Brain Antibodies  >88 publications with ILGFBP1 and Brain
 Lung Antibodies  >48 publications with ILGFBP1 and Lung
 Pancreas Antibodies  >33 publications with ILGFBP1 and Pancreas
 Skin Antibodies  >32 publications with ILGFBP1 and Skin
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