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IMPA1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203493
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IMPA1, Recombinant Protein

★Popular Item★
 Also Known As   

IMPA1, 1-277aa, Human, His tag, E Coli

 Product Synonym Names    Inositol monophosphatase 1; IMPA; IMP; IMPase 1; Inositol monophosphatase 1
 Product Gene Name   

IMPA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMATP PKRSCPSFSA SSEGTRIKKI SIEGNIAAGK STFVNILKQL CEDWEVVPEP VARWCNVQST QDEFEELTMS QKNGGNVLQM MYEKPERWSF TFQTYACLSR IRAQLASLNG KLKDAEKPVL FFERSVYSDR YIFASNLYES ECMNETEWTI YQDWHDWMNN QFGQSLELDG IIYLQATPET CLHRIYLRGR NEEQGIPLEY LEKLHYKHES WLLHRTLKTN FDYLQEVPIL TLDVNEDFKD KYESLVEKVK EFLSTL
 OMIM    X66922 mRNA
 3D Structure    ModBase 3D Structure for P29218
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of IMPA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IMPA1 recombinant protein

   IMPA1 (inositol monophosphatase1) is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. It plays a key role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. This protein has been identified as the pharmacological target for lithium action in the brain. Recombinant human IMPA1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for IMPA1 recombinant protein    Metabolism
 Applications Tested/Suitable for IMPA1 recombinant protein   

SDS-PAGE

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 SDS-Page of IMPA1 recombinant protein    IMPA1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for IMPA1. It may not necessarily be applicable to this product.
 NCBI GI #    5031789
 NCBI GeneID    3612
 NCBI Accession #    NP_005527 [Other Products]
 NCBI GenBank Nucleotide #    NM_005536.3 [Other Products]
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 UniProt Primary Accession #    P29218 [Other Products]
 UniProt Secondary Accession #    Q9UK71; B2R733; B4DLN3; B7Z6Q4; J3KQT7 [Other Products]
 UniProt Related Accession #    P29218 [Other Products]
 Molecular Weight    32.3 kDa (297aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    inositol monophosphatase 1 isoform 1
 NCBI Official Synonym Full Names    inositol monophosphatase 1
 NCBI Official Symbol    IMPA1 [Similar Products]
 NCBI Official Synonym Symbols   
IMP; IMPA; MRT59
[Similar Products]
 NCBI Protein Information    inositol monophosphatase 1
 UniProt Protein Name    Inositol monophosphatase 1
 UniProt Synonym Protein Names   
D-galactose 1-phosphate phosphatase
 Protein Family    Inositol monophosphatase
 UniProt Gene Name    IMPA1 [Similar Products]
 UniProt Synonym Gene Names    IMPA; IMP 1; IMPase 1 [Similar Products]
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 NCBI Summary for IMPA1    This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
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 UniProt Comments for IMPA1    Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
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Product References and Citations for IMPA1 recombinant protein

   Schapiro MB., et al. (2002) Neurobiol Aging. 23 (3):389-96.; Atack JR., et al. (1992) Proc Natl Acad Sci u S A. 89 (21):10031-5.;
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 Research Articles on IMPA1    1. The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IMPA1 recombinant proteinPathways associated with IMPA1 recombinant protein
 Reference Product  PubMed Publications
 IMPA2 recombinant protein  >13 publications with IMPA1 and IMPA2
 ISYNA1 recombinant protein  >2 publications with IMPA1 and ISYNA1
 PLCB1 recombinant protein  >1 publications with IMPA1 and PLCB1
 PLCD1 recombinant protein  >1 publications with IMPA1 and PLCD1
 INPP1 recombinant protein  >1 publications with IMPA1 and INPP1
 Products by Pathway  Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with IMPA1 recombinant proteinOrgans/Tissues associated with IMPA1 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with IMPA1 and Disease Models, Animal
 Seizures Antibodies  >4 publications with IMPA1 and Seizures
 Brain Diseases Antibodies  >3 publications with IMPA1 and Brain Diseases
 Nerve Degeneration Antibodies  >2 publications with IMPA1 and Nerve Degeneration
 Neurobehavioral Manifestations Antibodies  >1 publications with IMPA1 and Neurobehavioral Manifestations
 Cardiovascular Diseases Antibodies  >1 publications with IMPA1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with IMPA1 and Heart Diseases
 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 59 Antibodies  >1 publications with IMPA1 and MENTAL RETARDATION, AUTOSOMAL RECESSIVE 59
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with IMPA1 and Brain
 Blood Antibodies  >8 publications with IMPA1 and Blood
 Kidney Antibodies  >4 publications with IMPA1 and Kidney
 Muscle Antibodies  >4 publications with IMPA1 and Muscle
 Intestine Antibodies  >3 publications with IMPA1 and Intestine
 Skin Antibodies  >3 publications with IMPA1 and Skin
 Eye Antibodies  >2 publications with IMPA1 and Eye
 Heart Antibodies  >2 publications with IMPA1 and Heart
 Lung Antibodies  >1 publications with IMPA1 and Lung
 Thyroid Antibodies  >1 publications with IMPA1 and Thyroid
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