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IMPDH2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204353
SDS-PAGE
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IMPDH2, Recombinant Protein

 Also Known As   

IMPDH2, 1-514aa, Human, His tag, E Coli

 Product Synonym Names    Inosine-5'-monophosphate dehydrogenase 2; IMPD2; IMPDH-II
 Product Gene Name   

IMPDH2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCFLEEIMT KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 150mM NaCl
 Concentration    0.5mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of IMPDH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IMPDH2 recombinant protein

   IMPDH2 belongs to the IMPDH/GMPR family. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. Also IMPDH1 and IMPDH2 are targets for the important immunosuppressive drug, mycophenolic acid (MPA). Recombinant human IMPDH2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for IMPDH2 recombinant protein    Metabolism
 Applications Tested/Suitable for IMPDH2 recombinant protein   

SDS-PAGE

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 SDS-PAGE of IMPDH2 recombinant protein    IMPDH2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.
 NCBI GI #    66933016
 NCBI GeneID    3615
 NCBI Accession #    NP_000875 [Other Products]
 NCBI GenBank Nucleotide #    NM_000884.2 [Other Products]
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 UniProt Secondary Accession #    Q6LEF3 [Other Products]
 UniProt Related Accession #    P12268 [Other Products]
 Molecular Weight    58.0kDa (534aa)
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 NCBI Official Full Name    inosine-5'-monophosphate dehydrogenase 2
 NCBI Official Synonym Full Names    IMP (inosine 5'-monophosphate) dehydrogenase 2
 NCBI Official Symbol    IMPDH2 [Similar Products]
 NCBI Official Synonym Symbols   
IMPD2; IMPDH-II
[Similar Products]
 NCBI Protein Information    inosine-5'-monophosphate dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPDH 2; IMPDH2; inosine 5' phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II
 UniProt Protein Name    Inosine-5'-monophosphate dehydrogenase 2
 UniProt Synonym Protein Names   
IMPDH-II
 UniProt Gene Name    IMPDH2 [Similar Products]
 UniProt Synonym Gene Names    ; ; [Similar Products]
 UniProt Entry Name    IMDH2_HUMAN
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 NCBI Summary for IMPDH2    This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IMPDH2    IMPDH2: a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.

Protein type: EC 1.1.1.205; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: peroxisomal membrane; membrane; cytoplasm; nucleus; cytosol

Molecular Function: DNA binding; RNA binding; metal ion binding; nucleotide binding; IMP dehydrogenase activity

Biological Process: purine ribonucleoside monophosphate biosynthetic process; lymphocyte proliferation; nucleobase, nucleoside and nucleotide metabolic process; retina development in camera-type eye; GMP biosynthetic process; purine base metabolic process; protein homotetramerization
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Product References and Citations for IMPDH2 recombinant protein

   Wu TY, Peng Y, et al. (2010) Pharmacol. 161(7):1584-98.
Bremer S, et al. (2008) Transplantation. 85(1):55-61.
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 Research Articles on IMPDH2    1. the localization of IMPDH2 inside the nucleus of human cells as well as the ultrastructure of R&R inclusions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IMPDH2 recombinant proteinPathways associated with IMPDH2 recombinant protein
 Reference Product  PubMed Publications
 HPRT1 recombinant protein  >3 publications with IMPDH2 and HPRT1
 ITPA recombinant protein  >2 publications with IMPDH2 and ITPA
 GMPR2 recombinant protein  >1 publications with IMPDH2 and GMPR2
 GMPS recombinant protein  >1 publications with IMPDH2 and GMPS
 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
Diseases associated with IMPDH2 recombinant proteinOrgans/Tissues associated with IMPDH2 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with IMPDH2 and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with IMPDH2 and Kidney Diseases
 Leukemia Antibodies  >4 publications with IMPDH2 and Leukemia
 Inflammation Antibodies  >3 publications with IMPDH2 and Inflammation
 Diarrhea Antibodies  >3 publications with IMPDH2 and Diarrhea
 Neoplasms, Experimental Antibodies  >2 publications with IMPDH2 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >2 publications with IMPDH2 and Neoplasm Metastasis
 Prostatic Diseases Antibodies  >2 publications with IMPDH2 and Prostatic Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with IMPDH2 and Uterine Cervical Neoplasms
 Anemia Antibodies  >1 publications with IMPDH2 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with IMPDH2 and Blood
 Kidney Antibodies  >18 publications with IMPDH2 and Kidney
 Liver Antibodies  >4 publications with IMPDH2 and Liver
 Prostate Antibodies  >4 publications with IMPDH2 and Prostate
 Bone Antibodies  >4 publications with IMPDH2 and Bone
 Pancreas Antibodies  >2 publications with IMPDH2 and Pancreas
 Heart Antibodies  >2 publications with IMPDH2 and Heart
 Eye Antibodies  >2 publications with IMPDH2 and Eye
 Testis Antibodies  >1 publications with IMPDH2 and Testis
 Uterus Antibodies  >1 publications with IMPDH2 and Uterus
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