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IP-10 recombinant protein

Scan QR to view Datasheet Catalog #    MBS232354 IP-10 recombinant protein
Unit / Price
0.025 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IP-10, Recombinant Protein

 Also Known As   

RECOMBINANT MOUSE IP-10

 Product Gene Name   

IP-10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P17515
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 Purity/Purification    >98% by SDS page and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 1.0 mg/ml (lot specific)
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 Reconstitution    Reconstitute with 25 ul distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Target Species    Mouse
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of IP-10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IP-10 recombinant protein

   Murine Interferon Gamma Inducible Protein (IP-10), also known as CXCL 10, is an 8.5kDa chemokine expressed in a variety of murine tissues including liver, kidney, gut, thymus and spleen in response to interferon gamma. IP-10 acts as a chemoattractant for monocytes, NK cells and certain T-cells. It is thought NK cells have an anti-tumour effect for several types of cancer and may play a role in the repair and regeneration of hepatic tissue.
 Applications Tested/Suitable for IP-10 recombinant protein   

Functional Assays (FN)

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NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.
 NCBI GI #    10946576
 NCBI GeneID    15945
 NCBI Accession #    NP_067249.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021274.2 [Other Products]
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 UniProt Primary Accession #    P17515 [Other Products]
 UniProt Related Accession #    P17515 [Other Products]
 Molecular Weight    Protein Molecular Weight: 8.5kDa (77 amino acid sequence)
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 NCBI Official Full Name    C-X-C motif chemokine 10
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 10
 NCBI Official Symbol    Cxcl10 [Similar Products]
 NCBI Official Synonym Symbols   
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; gamma-IP10; interferon activated gene 10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10
 UniProt Protein Name    C-X-C motif chemokine 10
 UniProt Synonym Protein Names   
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10
 UniProt Gene Name    Cxcl10 [Similar Products]
 UniProt Synonym Gene Names    Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10 [Similar Products]
 UniProt Entry Name    CXL10_MOUSE
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 UniProt Comments for IP-10    CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of myoblast differentiation; inflammatory response; defense response to virus; positive regulation of cell migration
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 Research Articles on IP-10    1. IP-10 levels were measured to test epithelial secretion in cytic fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IP-10 recombinant proteinDiseases associated with IP-10 recombinant protein
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1158 publications with IP-10 and Inflammation
 Necrosis Antibodies  >668 publications with IP-10 and Necrosis
 Disease Models, Animal Antibodies  >337 publications with IP-10 and Disease Models, Animal
 Lung Diseases Antibodies  >332 publications with IP-10 and Lung Diseases
 Liver Diseases Antibodies  >229 publications with IP-10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >169 publications with IP-10 and Cardiovascular Diseases
 Fibrosis Antibodies  >126 publications with IP-10 and Fibrosis
 Neoplasms, Experimental Antibodies  >113 publications with IP-10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >86 publications with IP-10 and Kidney Diseases
 Lung Injury Antibodies  >63 publications with IP-10 and Lung Injury
Organs/Tissues associated with IP-10 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >159 publications with IP-10 and Lymph Node
 Spleen Antibodies  >129 publications with IP-10 and Spleen
 Bone Marrow Antibodies  >124 publications with IP-10 and Bone Marrow
 Eye Antibodies  >94 publications with IP-10 and Eye
 Intestine Antibodies  >90 publications with IP-10 and Intestine
 Embryonic Tissue Antibodies  >52 publications with IP-10 and Embryonic Tissue
 Thymus Antibodies  >52 publications with IP-10 and Thymus
 Mammary Gland Antibodies  >8 publications with IP-10 and Mammary Gland
 Epididymis Antibodies  >1 publications with IP-10 and Epididymis
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