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IP10 recombinant protein

Scan QR to view Datasheet Catalog #    MBS538288 IP10 recombinant protein
Unit / Price
0.025 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IP10, Recombinant Protein

 Also Known As   

IP10 protein

 Product Synonym Names    IP-10 protein; gamma-Interferon Inducible Protein 10 protein; crg-2 protein; IP10; IP-10; CXCL10 protein; IP 10 protein; IP 10
 Product Gene Name   

IP10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of IP10 protein correspond ing to amino acids VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK EMSKRSP.
 3D Structure    ModBase 3D Structure for P17515
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Sterile filtered through a 0.2 um filter. Lyophilized with no additives.
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 Protein Type    Recombinant
 Biological Significance    IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells.
 Bioactivity    Determined by its ability to chemoattract human T-lymphoytes using a concentration of 10-50 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IP10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IP10 recombinant protein

   Purified recombinant Human IP10 protein
 Product Categories/Family for IP10 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for IP10 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for IP10. It may not necessarily be applicable to this product.
 NCBI GI #    976159
 NCBI GeneID    15945
 NCBI Accession #    AAA75249.1 [Other Products]
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 UniProt Primary Accession #    P17515 [Other Products]
 UniProt Related Accession #    P17515 [Other Products]
 Molecular Weight    10,789 Da
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 NCBI Official Full Name    IP-10
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 10
 NCBI Official Symbol    Cxcl10 [Similar Products]
 NCBI Official Synonym Symbols   
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 10
 UniProt Protein Name    C-X-C motif chemokine 10
 UniProt Synonym Protein Names   
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10
 UniProt Gene Name    Cxcl10 [Similar Products]
 UniProt Synonym Gene Names    Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10 [Similar Products]
 UniProt Entry Name    CXL10_MOUSE
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 UniProt Comments for IP10    CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of myoblast differentiation; inflammatory response; defense response to virus; positive regulation of cell migration
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 Research Articles on IP10    1. tumours are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IP10 recombinant proteinPathways associated with IP10 recombinant protein
 Reference Product  PubMed Publications
 Cxcl9 recombinant protein  >949 publications with IP10 and Cxcl9
 Cxcr3 recombinant protein  >848 publications with IP10 and Cxcr3
 Ccl5 recombinant protein  >662 publications with IP10 and Ccl5
 Ccr5 recombinant protein  >177 publications with IP10 and Ccr5
 Cxcl2 recombinant protein  >116 publications with IP10 and Cxcl2
 Ccl20 recombinant protein  >110 publications with IP10 and Ccl20
 Cxcl5 recombinant protein  >66 publications with IP10 and Cxcl5
 Cxcl13 recombinant protein  >52 publications with IP10 and Cxcl13
 Cxcr5 recombinant protein  >28 publications with IP10 and Cxcr5
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
Diseases associated with IP10 recombinant proteinOrgans/Tissues associated with IP10 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1210 publications with IP10 and Inflammation
 Necrosis Antibodies  >682 publications with IP10 and Necrosis
 Disease Models, Animal Antibodies  >351 publications with IP10 and Disease Models, Animal
 Lung Diseases Antibodies  >342 publications with IP10 and Lung Diseases
 Liver Diseases Antibodies  >242 publications with IP10 and Liver Diseases
 Brain Diseases Antibodies  >212 publications with IP10 and Brain Diseases
 Cardiovascular Diseases Antibodies  >177 publications with IP10 and Cardiovascular Diseases
 Fibrosis Antibodies  >129 publications with IP10 and Fibrosis
 Neoplasms, Experimental Antibodies  >119 publications with IP10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >89 publications with IP10 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >163 publications with IP10 and Lymph Node
 Spleen Antibodies  >133 publications with IP10 and Spleen
 Bone Marrow Antibodies  >131 publications with IP10 and Bone Marrow
 Eye Antibodies  >97 publications with IP10 and Eye
 Intestine Antibodies  >94 publications with IP10 and Intestine
 Embryonic Tissue Antibodies  >53 publications with IP10 and Embryonic Tissue
 Thymus Antibodies  >53 publications with IP10 and Thymus
 Mammary Gland Antibodies  >8 publications with IP10 and Mammary Gland
 Epididymis Antibodies  >1 publications with IP10 and Epididymis
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