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IGHA1 recombinant protein :: Ig alpha-1 chain C region (IGHA1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950448 IGHA1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $765 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $880 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,010 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,020 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,260 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,285 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,335 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,595 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,845 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,910 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,030 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,455 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ig alpha-1 chain C region (IGHA1), Recombinant Protein

 Also Known As   

Recombinant Human Ig alpha-1 chain C region (IGHA1)

 Product Synonym Names    Ig alpha-1 chain C region
 Product Gene Name   

IGHA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-353aa; Full length protein
 Sequence    ASPTSPKVFP LSLCSTQPDG NVVIACLVQG FFPQEPLSVT WSESGQGVTA RNFPPSQDAS GDLYTTSSQL TLPATQCLAG KSVTCHVKHY TNPSQDVTVP CPVPSTPPTP SPSTPPTPSP SCCHPRLSLH RPALEDLLLG SEANLTCTLT GLRDASGVTF TWTPSSGKSA VQGPPERDLC GCYSVSSVLP GCAEPWNHGK TFTCTAAYPE SKTPLTATLS KSGNTFRPEV HLLPPPSEEL ALNELVTLTC LARGFSPKDV LVRWLQGSQE LPREKYLTWA SRQEPSQGTT TFAVTSILRV AAEDWKKGDT FSCMVGHEAL PLAFTQKTID RLAGKPTHVN VSVVMAEVDG TCY
 OMIM    146900
 3D Structure    ModBase 3D Structure for P01876
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IGHA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IGHA1. It may not necessarily be applicable to this product.
 NCBI GI #    113584
 NCBI GeneID    3493
 NCBI Accession #    P01876.2 [Other Products]
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 UniProt Primary Accession #    P01876 [Other Products]
 Molecular Weight    37,655 Da
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 NCBI Official Full Name    Ig alpha-1 chain C region, partial
 UniProt Protein Name    Ig alpha-1 chain C region
 Protein Family    Ig alpha-1 chain C region
 UniProt Gene Name    IGHA1 [Similar Products]
 UniProt Entry Name    IGHA1_HUMAN
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 UniProt Comments for IGHA1    IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: antigen binding

Biological Process: retinal homeostasis; receptor-mediated endocytosis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage
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 Research Articles on IGHA1    1. The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IGHA1 recombinant proteinOrgans/Tissues associated with IGHA1 recombinant protein
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with IGHA1 and Blood
 Brain Antibodies  >1 publications with IGHA1 and Brain
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