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IDO1 recombinant protein :: Indoleamine 2,3-dioxygenase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967278
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $150 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $170 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $220 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $345 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $545 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $900 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,050 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,300 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,335 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,410 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,915 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,965 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,525 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Indoleamine 2,3-dioxygenase 1 (IDO1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Indoleamine 2,3-dioxygenase 1

 Product Synonym Names    Indoleamine-pyrrole 2,3-dioxygenase
 Product Gene Name   

IDO1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-403. Full length.
 Sequence    MAHAMENSWT ISKEYHIDEE VGFALPNPQE NLPDFYNDWM FIAKHLPDLI ESGQLRERVE KLNMLSIDHL TDHKSQRLAR LVLGCITMAY VWGKGHGDVR KVLPRNIAVP YCQLSKKLEL PPILVYADCV LANWKKKDPN KPLTYENMDV LFSFRDGDCS KGFFLVSLLV EIAAASAIKV IPTVFKAMQM QERDTLLKAL LEIASCLEKA LQVFHQIHDH VNPKAFFSVL RIYLSGWKGN PQLSDGLVYE GFWEDPKEFA GGSAGQSSVF QCF DVLLG IQQTAGGGHA AQFLQDMRRY MPPAHRNFLC SLESNPSVRE FVLSKGDAGL REAYDACVKA LVSLRSYHLQ IVTKYILIPA SQQPKENKTS EDPSKLEAKG TGGTDLMNFL KTVRSTTEKS LLKEG
 OMIM    147435
 3D Structure    ModBase 3D Structure for P14902
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IDO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IDO1 recombinant protein

   Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
 Product Categories/Family for IDO1 recombinant protein    Cardiovascular
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 SDS-PAGE of IDO1 recombinant protein    IDO1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for IDO1. It may not necessarily be applicable to this product.
 NCBI GI #    4504577
 NCBI GeneID    3620
 NCBI Accession #    NP_002155.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002164.5 [Other Products]
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 UniProt Primary Accession #    P14902 [Other Products]
 UniProt Secondary Accession #    Q540B4; E5RGR8; F6M9T7 [Other Products]
 UniProt Related Accession #    P14902 [Other Products]
 Molecular Weight    49.4kD
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 NCBI Official Full Name    indoleamine 2,3-dioxygenase 1
 NCBI Official Synonym Full Names    indoleamine 2,3-dioxygenase 1
 NCBI Official Symbol    IDO1 [Similar Products]
 NCBI Official Synonym Symbols   
IDO; INDO; IDO-1
[Similar Products]
 NCBI Protein Information    indoleamine 2,3-dioxygenase 1
 UniProt Protein Name    Indoleamine 2,3-dioxygenase 1
 UniProt Synonym Protein Names   
Indoleamine-pyrrole 2,3-dioxygenase
 Protein Family    Indoleamine 2,3-dioxygenase
 UniProt Gene Name    IDO1 [Similar Products]
 UniProt Synonym Gene Names    IDO; INDO; IDO-1 [Similar Products]
 UniProt Entry Name    I23O1_HUMAN
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 NCBI Summary for IDO1    This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
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 UniProt Comments for IDO1    INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family.

Protein type: Cell cycle regulation; Oxidoreductase; EC 1.13.11.52; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: 8p12-p11

Cellular Component: cytosol; smooth muscle contractile fiber; stereocilium bundle

Molecular Function: electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; tryptophan 2,3-dioxygenase activity

Biological Process: cytokine production during acute inflammatory response; female pregnancy; immune system process; multicellular organismal response to stress; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; positive regulation of chronic inflammatory response; positive regulation of interleukin-12 production; positive regulation of T cell tolerance induction; positive regulation of T-helper 2 type immune response; regulation of activated T cell proliferation; response to lipopolysaccharide; tryptophan catabolic process; tryptophan catabolic process to kynurenine
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Product References and Citations for IDO1 recombinant protein

   Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA.Dai W., Gupta S.L.Biochem. Biophys. Res. Commun. 168:1-8(1990) Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA.Tone S., Takikawa O., Habara-Ohkubo A., Kadoya A., Yoshida R., Kido R.Nucleic Acids Res. 18:367-367(1990) Gene structure of human indoleamine 2,3-dioxygenase.Kadoya A., Tone S., Maeda H., Minatogawa Y., Kido R.Biochem. Biophys. Res. Commun. 189:530-536(1992) Human indoleamine 2,3-dioxygenase from peripheral blood.He X., Xu L., Liu Y., Zeng Y. Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan.Metz R., Duhadaway J.B., Kamasani U., Laury-Kleintop L., Muller A.J., Prendergast G.C.Cancer Res. 67:7082-7087(2007) Evolution of vertebrate indoleamine 2,3-dioxygenases.Yuasa H.J., Takubo M., Takahashi A., Hasegawa T., Noma H., Suzuki T.J. Mol. Evol. 65:705-714(2007) Crystal structure of human indoleamine 2,3-dioxygenase catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.Sugimoto H., Oda S., Otsuki T., Hino T., Yoshida T., Shiro Y.Proc. Natl. Acad. Sci. U.S.A. 103:2611-2616(2006)
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 Research Articles on IDO1    1. We found a definitive relation between IDO1 induction on acute myeloid leukemia blasts mediated by NK cell-produced IFNgamma and the consequent functional deregulation of NK cells that favors AML immune escape.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IDO1 recombinant proteinPathways associated with IDO1 recombinant protein
 Reference Product  PubMed Publications
 KYNU recombinant protein  >3 publications with IDO1 and KYNU
 CYP1A1 recombinant protein  >1 publications with IDO1 and CYP1A1
 TPH1 recombinant protein  >1 publications with IDO1 and TPH1
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies  Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
 L-kynurenine Degradation Pathway antibodies  L-kynurenine Degradation Pathway Diagram
 L-tryptophan Degradation III (eukaryotic) Pathway antibodies  L-tryptophan Degradation III (eukaryotic) Pathway Diagram
 L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway antibodies  L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway Diagram
 L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
Diseases associated with IDO1 recombinant proteinOrgans/Tissues associated with IDO1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >64 publications with IDO1 and Inflammation
 Colitis Antibodies  >11 publications with IDO1 and Colitis
 Neoplasms, Experimental Antibodies  >11 publications with IDO1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >8 publications with IDO1 and Lung Diseases
 Necrosis Antibodies  >7 publications with IDO1 and Necrosis
 Neurodegenerative Diseases Antibodies  >7 publications with IDO1 and Neurodegenerative Diseases
 Breast Neoplasms Antibodies  >6 publications with IDO1 and Breast Neoplasms
 Liver Diseases Antibodies  >5 publications with IDO1 and Liver Diseases
 Cognition Disorders Antibodies  >4 publications with IDO1 and Cognition Disorders
 Endometriosis Antibodies  >4 publications with IDO1 and Endometriosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with IDO1 and Brain
 Bone Antibodies  >20 publications with IDO1 and Bone
 Lung Antibodies  >18 publications with IDO1 and Lung
 Liver Antibodies  >10 publications with IDO1 and Liver
 Intestine Antibodies  >8 publications with IDO1 and Intestine
 Uterus Antibodies  >7 publications with IDO1 and Uterus
 Kidney Antibodies  >6 publications with IDO1 and Kidney
 Placenta Antibodies  >6 publications with IDO1 and Placenta
 Embryonic Tissue Antibodies  >4 publications with IDO1 and Embryonic Tissue
 Eye Antibodies  >4 publications with IDO1 and Eye
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