NP_032588.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48.9 kDa
NCBI Official Full Name
induced myeloid leukemia cell differentiation protein Mcl-1 homolog
NCBI Official Synonym Full Names
myeloid cell leukemia sequence 1
NCBI Protein Information
induced myeloid leukemia cell differentiation protein Mcl-1 homolog
UniProt Protein Name
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
UniProt Synonym Protein Names
Bcl-2-related protein EAT/mcl1
UniProt Entry Name
MCL1_MOUSE
UniProt Comments for Mcl1
MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
Protein type: Inhibitor; Channel, misc.; Mitochondrial; Apoptosis; Membrane protein, integral
Cellular Component: cytoplasm; cytosol; integral to membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function: BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity
Biological Process: apoptosis; apoptotic mitochondrial changes; cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; negative regulation of apoptosis; regulation of apoptosis; response to cytokine stimulus
Product References and Citations for Mcl1 recombinant protein
Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells.Okita H., Umezawa A., Suzuki A., Hata J.Biochim. Biophys. Acta 1398:335-341(1998)
MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair.Kojima S., Hyakutake A., Koshikawa N., Nakagawara A., Takenaga K.Biochem. Biophys. Res. Commun. 391:492-497(2010)
Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009)
Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF)
signaling pathway and is one component of the GM-CSF viability response.Chao J.-R., Wang J.-M., Lee S.-F., Peng H.-W., Lin Y.-H., Chou C.-H., Li J.-C., Huang H.-M., Chou C.-K., Kuo M.-L., Yen J.J.-Y., Yang-Yen H.-F.Mol. Cell. Biol. 18:4883-4898(1998)
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.Mol. Cell 21:749-760(2006)
Pro-apoptotic activity of inhibitory PAS domain protein (IPAS)
, a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.Torii S., Goto Y., Ishizawa T., Hoshi H., Goryo K., Yasumoto K., Fukumura H., Sogawa K.Cell Death Differ. 18:1711-1725(2011)
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.Day C.L., Chen L., Richardson S.J., Harrison P.J., Huang D.C.S., Hinds M.G.J. Biol. Chem. 280:4738-4744(2005)
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.Day C.L., Smits C., Fan F.C., Lee E.F., Fairlie W.D., Hinds M.G.J. Mol. Biol. 380:958-971(2008)
Research Articles on Mcl1
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Products associated with Mcl1 recombinant protein
Pathways associated with Mcl1 recombinant protein
Diseases associated with Mcl1 recombinant protein
Organs/Tissues associated with Mcl1 recombinant protein
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