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Mcl1 recombinant protein :: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS954058
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

 Product Synonym Names    Bcl-2-related protein EAT/mcl1
 Product Gene Name   

Mcl1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-308aa; Partial
 Sequence    MFGLRRNAVI GLNLYCGGAS LGAGGGSPAG ARLVAEEAKA RREGGGEAAL LPGARVVARP PPVGAEDPDV TASAERRLHK SPGLLAVPPE EMAASAAAAI VSPEEELDGC EPEAIGKRPA VLPLLERVSE AAKSSGADGS LPSTPPPPEE EEDDLYRQSL EIISRYLREQ ATGSKDSKPL GEAGAAGRRA LETLRRVGDG VQRNHETAFQ GMLRKLDIKN EGDVKSFSRV MVHVFKDGVT NWGRIVTLIS FGAFVAKHLK SVNQESFIEP LAETITDVLV RTKRDWLVKQ RGWDGFVEFF HVQDLEGG
 3D Structure    ModBase 3D Structure for P97287
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Mcl1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Mcl1 recombinant protein

   Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity.
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 SDS-PAGE of Mcl1 recombinant protein    Mcl1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Mcl1. It may not necessarily be applicable to this product.
 NCBI GI #    6678824
 NCBI GeneID    17210
 NCBI Accession #    NP_032588.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008562.3 [Other Products]
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 UniProt Primary Accession #    P97287 [Other Products]
 UniProt Secondary Accession #    Q3TUS0; Q792P0; Q9CRI4; D2K6L9 [Other Products]
 UniProt Related Accession #    P97287 [Other Products]
 Molecular Weight    48.9kD
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 NCBI Official Full Name    induced myeloid leukemia cell differentiation protein Mcl-1 homolog
 NCBI Official Synonym Full Names    myeloid cell leukemia sequence 1
 NCBI Official Symbol    Mcl1 [Similar Products]
 NCBI Official Synonym Symbols   
Mcl-1; AW556805
[Similar Products]
 NCBI Protein Information    induced myeloid leukemia cell differentiation protein Mcl-1 homolog
 UniProt Protein Name    Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
 UniProt Synonym Protein Names   
Bcl-2-related protein EAT/mcl1
 Protein Family    Induced myeloid leukemia cell differentiation protein
 UniProt Gene Name    Mcl1 [Similar Products]
 UniProt Entry Name    MCL1_MOUSE
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 UniProt Comments for Mcl1    MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Protein type: Inhibitor; Channel, misc.; Mitochondrial; Apoptosis; Membrane protein, integral

Cellular Component: cytoplasm; cytosol; integral to membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleus

Molecular Function: BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity

Biological Process: apoptosis; apoptotic mitochondrial changes; cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; negative regulation of apoptosis; regulation of apoptosis; response to cytokine stimulus
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Product References and Citations for Mcl1 recombinant protein

   Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells.Okita H., Umezawa A., Suzuki A., Hata J.Biochim. Biophys. Acta 1398:335-341(1998) MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair.Kojima S., Hyakutake A., Koshikawa N., Nakagawara A., Takenaga K.Biochem. Biophys. Res. Commun. 391:492-497(2010) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response.Chao J.-R., Wang J.-M., Lee S.-F., Peng H.-W., Lin Y.-H., Chou C.-H., Li J.-C., Huang H.-M., Chou C.-K., Kuo M.-L., Yen J.J.-Y., Yang-Yen H.-F.Mol. Cell. Biol. 18:4883-4898(1998) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.Mol. Cell 21:749-760(2006) Pro-apoptotic activity of inhibitory PAS domain protein (IPAS) , a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.Torii S., Goto Y., Ishizawa T., Hoshi H., Goryo K., Yasumoto K., Fukumura H., Sogawa K.Cell Death Differ. 18:1711-1725(2011) Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.Day C.L., Chen L., Richardson S.J., Harrison P.J., Huang D.C.S., Hinds M.G.J. Biol. Chem. 280:4738-4744(2005) Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.Day C.L., Smits C., Fan F.C., Lee E.F., Fairlie W.D., Hinds M.G.J. Mol. Biol. 380:958-971(2008)
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 Research Articles on Mcl1    1. Tax interacted with and activated TRAF6, and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with lysine 63-linked polyubiquitin chains
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Mcl1 recombinant proteinPathways associated with Mcl1 recombinant protein
 Reference Product  PubMed Publications
 Bax recombinant protein  >204 publications with Mcl1 and Bax
 Pmaip1 recombinant protein  >53 publications with Mcl1 and Pmaip1
 Bak1 recombinant protein  >44 publications with Mcl1 and Bak1
 Bid recombinant protein  >35 publications with Mcl1 and Bid
 Trp53 recombinant protein  >31 publications with Mcl1 and Trp53
 Bcl2l2 recombinant protein  >16 publications with Mcl1 and Bcl2l2
 Usp9x recombinant protein  >14 publications with Mcl1 and Usp9x
 Akt1 recombinant protein  >10 publications with Mcl1 and Akt1
 Apaf1 recombinant protein  >4 publications with Mcl1 and Apaf1
 Bcl2l11 recombinant protein  >4 publications with Mcl1 and Bcl2l11
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with Mcl1 recombinant proteinOrgans/Tissues associated with Mcl1 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >70 publications with Mcl1 and Lung Neoplasms
 Lung Diseases Antibodies  >69 publications with Mcl1 and Lung Diseases
 Necrosis Antibodies  >55 publications with Mcl1 and Necrosis
 Breast Neoplasms Antibodies  >53 publications with Mcl1 and Breast Neoplasms
 Liver Diseases Antibodies  >47 publications with Mcl1 and Liver Diseases
 Multiple Myeloma Antibodies  >40 publications with Mcl1 and Multiple Myeloma
 Liver Neoplasms Antibodies  >37 publications with Mcl1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >35 publications with Mcl1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >34 publications with Mcl1 and Neoplasms, Experimental
 Inflammation Antibodies  >32 publications with Mcl1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >176 publications with Mcl1 and Blood
 Lung Antibodies  >95 publications with Mcl1 and Lung
 Liver Antibodies  >80 publications with Mcl1 and Liver
 Bone Antibodies  >72 publications with Mcl1 and Bone
 Bone Marrow Antibodies  >56 publications with Mcl1 and Bone Marrow
 Brain Antibodies  >45 publications with Mcl1 and Brain
 Prostate Antibodies  >39 publications with Mcl1 and Prostate
 Skin Antibodies  >27 publications with Mcl1 and Skin
 Lymph Node Antibodies  >19 publications with Mcl1 and Lymph Node
 Pancreas Antibodies  >16 publications with Mcl1 and Pancreas
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