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INHBA recombinant protein :: Inhibin beta A chain Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955336
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $675 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $835 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $915 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,025 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,050 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,070 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,520 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,560 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,635 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,035 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Inhibin beta A chain (INHBA), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Inhibin beta A chain

 Product Synonym Names    Activin beta-A chain; Erythroid differentiation protein; EDF
 Product Gene Name   

INHBA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    311-426aa; Full Length
 Sequence    GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
 OMIM    147290
 3D Structure    ModBase 3D Structure for P08476
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of INHBA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for INHBA recombinant protein

   Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
 Product Categories/Family for INHBA recombinant protein    Signal Transduction
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 SDS-PAGE of INHBA recombinant protein    INHBA recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for INHBA. It may not necessarily be applicable to this product.
 NCBI GI #    4504699
 NCBI GeneID    3624
 NCBI Accession #    NP_002183.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002192.2 [Other Products]
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 UniProt Primary Accession #    P08476 [Other Products]
 UniProt Secondary Accession #    Q14599 [Other Products]
 UniProt Related Accession #    P08476 [Other Products]
 Molecular Weight    28.97kD
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 NCBI Official Full Name    inhibin beta A chain
 NCBI Official Synonym Full Names    inhibin beta A
 NCBI Official Symbol    INHBA [Similar Products]
 NCBI Official Synonym Symbols   
EDF; FRP
[Similar Products]
 NCBI Protein Information    inhibin beta A chain
 UniProt Protein Name    Inhibin beta A chain
 UniProt Synonym Protein Names   
Activin beta-A chain; Erythroid differentiation protein; EDF
 Protein Family    Inhibin
 UniProt Gene Name    INHBA [Similar Products]
 UniProt Synonym Gene Names    EDF [Similar Products]
 UniProt Entry Name    INHBA_HUMAN
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 NCBI Summary for INHBA    The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for INHBA    INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p15-p13

Cellular Component: extracellular region; perinuclear region of cytoplasm

Molecular Function: cytokine activity; growth factor activity; hormone activity; identical protein binding; peptide hormone binding; protein binding; protein heterodimerization activity; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; cell cycle arrest; cell development; cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; defense response; erythrocyte differentiation; G1/S transition of mitotic cell cycle; growth; hair follicle development; hemoglobin biosynthetic process; hemopoietic progenitor cell differentiation; male gonad development; mesodermal cell differentiation; negative regulation of B cell differentiation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of follicle-stimulating hormone secretion; negative regulation of interferon-gamma biosynthetic process; negative regulation of macrophage differentiation; negative regulation of phosphorylation; nervous system development; odontogenesis; ovarian follicle development; palate development; positive regulation of cellular protein metabolic process; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; progesterone secretion; regulation of follicle-stimulating hormone secretion; regulation of MAPKKK cascade; regulation of transcription from RNA polymerase II promoter; response to drug; striatal medium spiny neuron differentiation
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Product References and Citations for INHBA recombinant protein

   Structure of two human ovarian inhibins.Mason A.J., Niall H.D., Seeburg P.H.Biochem. Biophys. Res. Commun. 135:957-964(1986) Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.Murata M., Eto Y., Shibai H., Sakai M., Muramatsu M.Proc. Natl. Acad. Sci. U.S.A. 85:2434-2438(1988) Structure and sequence analysis of the human activin beta A subunit gene.Tanimoto K., Handa S.I., Ueno N., Murakami K., Fukamizu A.DNA Seq. 2:103-110(1991) The DNA sequence of human chromosome 7.Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.Nature 424:157-164(2003) Human inhibin genes. Genomic characterisation and sequencing.Stewart A.G., Milborrow H.M., Ring J.M., Crowther C.E., Forage R.G.FEBS Lett. 206:329-334(1986) Berg H., Walter M., Northemann W. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG) .Schneyer A., Schoen A., Quigg A., Sidis Y.Endocrinology 144:1671-1674(2003) Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.Thompson T.B., Woodruff T.K., Jardetzky T.S.EMBO J. 22:1555-1566(2003) The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity.Stamler R., Keutmann H.T., Sidis Y., Kattamuri C., Schneyer A., Thompson T.B.J. Biol. Chem. 283:32831-32838(2008) Germline mutations of inhibins in early-onset ovarian epithelial tumors.Tournier I., Marlin R., Walton K., Charbonnier F., Coutant S., Thery J.C., Charbonnier C., Spurrell C., Vezain M., Ippolito L., Bougeard G., Roman H., Tinat J., Sabourin J.C., Stoppa-Lyonnet D., Caron O., Bressac-de Paillerets B., Vaur D., King M.C., Harrison C., Frebourg T.Hum. Mutat. 35:294-297(2014)
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 Research Articles on INHBA    1. Data suggest that activin A [plus bone morphogenic protein 4 (BMP4)] strongly stimulates germ cell differentiation potential of human embryonic stem cells; this stimulation appear to depend on gene expression regulation by activin A.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with INHBA recombinant proteinPathways associated with INHBA recombinant protein
 Reference Product  PubMed Publications
 INHBB recombinant protein  >25 publications with INHBA and INHBB
 INHA recombinant protein  >20 publications with INHBA and INHA
 FST recombinant protein  >14 publications with INHBA and FST
 FSTL3 recombinant protein  >3 publications with INHBA and FSTL3
 INHBC recombinant protein  >1 publications with INHBA and INHBC
 ACVR1B recombinant protein  >1 publications with INHBA and ACVR1B
 ACVR2B recombinant protein  >1 publications with INHBA and ACVR2B
 ACVR2A recombinant protein  >1 publications with INHBA and ACVR2A
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with INHBA recombinant proteinOrgans/Tissues associated with INHBA recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with INHBA and Inflammation
 Necrosis Antibodies  >7 publications with INHBA and Necrosis
 Disease Models, Animal Antibodies  >6 publications with INHBA and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with INHBA and Kidney Diseases
 Pre-Eclampsia Antibodies  >5 publications with INHBA and Pre-Eclampsia
 Lung Diseases Antibodies  >4 publications with INHBA and Lung Diseases
 Lung Neoplasms Antibodies  >4 publications with INHBA and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with INHBA and Cell Transformation, Neoplastic
 Uterine Neoplasms Antibodies  >3 publications with INHBA and Uterine Neoplasms
 Liver Diseases Antibodies  >2 publications with INHBA and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >23 publications with INHBA and Ovary
 Blood Antibodies  >23 publications with INHBA and Blood
 Bone Antibodies  >18 publications with INHBA and Bone
 Placenta Antibodies  >9 publications with INHBA and Placenta
 Lung Antibodies  >8 publications with INHBA and Lung
 Kidney Antibodies  >7 publications with INHBA and Kidney
 Brain Antibodies  >7 publications with INHBA and Brain
 Liver Antibodies  >6 publications with INHBA and Liver
 Vascular Antibodies  >6 publications with INHBA and Vascular
 Stomach Antibodies  >6 publications with INHBA and Stomach
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