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IMPD2 recombinant protein :: Inosine-5'-monophosphate dehydrogenase 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717083
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Inosine-5'-monophosphate dehydrogenase 2 (IMPD2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Inosine-5'-monophosphate dehydrogenase 2

 Product Synonym Names    IMPDH-II
 Product Gene Name   

IMPD2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    5-514aa; Partial
 Sequence    LISGGTSYVP DDGLTAQQLF NCGDGLTYND FLILPGYIDF TADQVDLTSA LTKKITLKTP LVSSPMDTVT EAGMAIAMAL TGGIGFIHHN CTPEFQANEV RKVKKYEQGF ITDPVVLSPK DRVRDVFEAK ARHGFCGIPI TDTGRMGSRL VGIISSRDID FLKEEEHDCF LEEIMTKRED LVVAPAGITL KEANEILQRS KKGKLPIVNE DDELVAIIAR TDLKKNRDYP LASKDAKKQL LCGAAIGTHE DDKYRLDLLA QAGVDVVVLD SSQGNSIFQI NMIKYIKDKY PNLQVIGGNV VTAAQAKNLI DAGVDALRVG MGSGSICITQ EVLACGRPQA TAVYKVSEYA RRFGVPVIAD GGIQNVGHIA KALALGASTV MMGSLLAATT EAPGEYFFSD GIRLKKYRGM GSLDAMDKHL SSQNRYFSEA DKIKVAQGVS GAVQDKGSIH KFVPYLIAGI QHSCQDIGAK SLTQVRAMMY SGELKFEKRT SSAQVEGGVH SLHSYEKRLF
 OMIM    146691
 3D Structure    ModBase 3D Structure for P12268
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IMPD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IMPD2 recombinant protein

   Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
 Product Categories/Family for IMPD2 recombinant protein    Cancer
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 SDS-PAGE of IMPD2 recombinant protein    IMPD2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for IMPD2. It may not necessarily be applicable to this product.
 NCBI GI #    66933016
 NCBI GeneID    3615
 NCBI Accession #    NP_000875.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000884.2 [Other Products]
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 UniProt Primary Accession #    P12268 [Other Products]
 UniProt Secondary Accession #    Q6LEF3 [Other Products]
 UniProt Related Accession #    P12268 [Other Products]
 Molecular Weight    82.7kD
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 NCBI Official Full Name    inosine-5'-monophosphate dehydrogenase 2
 NCBI Official Synonym Full Names    inosine monophosphate dehydrogenase 2
 NCBI Official Symbol    IMPDH2 [Similar Products]
 NCBI Official Synonym Symbols   
IMPD2; IMPDH-II
[Similar Products]
 NCBI Protein Information    inosine-5'-monophosphate dehydrogenase 2
 UniProt Protein Name    Inosine-5'-monophosphate dehydrogenase 2
 UniProt Synonym Protein Names   
IMPDH-II
 Protein Family    Inosine-5'-monophosphate dehydrogenase
 UniProt Gene Name    IMPDH2 [Similar Products]
 UniProt Synonym Gene Names    IMP dehydrogenase 2; IMPD 2; IMPDH 2 [Similar Products]
 UniProt Entry Name    IMDH2_HUMAN
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 NCBI Summary for IMPD2    This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IMPD2    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
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Product References and Citations for IMPD2 recombinant protein

   Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.Collart F.R., Huberman E.J. Biol. Chem. 263:15769-15772(1988) Two distinct cDNAs for human IMP dehydrogenase.Natsumeda Y., Ohno S., Kawasaki H., Konno Y., Weber G., Suzuki K.J. Biol. Chem. 265:5292-5295(1990) Cloning and sequence of the human type II IMP dehydrogenase gene.Glesne D.A., Huberman E.Biochem. Biophys. Res. Commun. 205:537-544(1994) Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.Zimmermann A.G., Spychala J., Mitchell B.S.J. Biol. Chem. 270:6808-6814(1995) Chromosomal localization and structure of the human type II IMP dehydrogenase gene.Glesne D.A., Collart F.R., Varkony T., Drabkin H., Huberman E.Genomics 16:274-277(1993) Characterization of human type I and type II IMP dehydrogenases.Carr S.F., Papp E., Wu J.C., Natsumeda Y.J. Biol. Chem. 268:27286-27290(1993) Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.Hager P.W., Collart F.R., Huberman E., Mitchell B.S.Biochem. Pharmacol. 49:1323-1329(1995) Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.McLean J.E., Hamaguchi N., Belenky P., Mortimer S.E., Stanton M., Hedstrom L.Biochem. J. 379:243-251(2004) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.Nat. Biotechnol. 23:94-101(2005) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.Cell 127:635-648(2006) A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.Wang J., Zeevi A., Webber S., Girnita D.M., Addonizio L., Selby R., Hutchinson I.V., Burckart G.J.Pharmacogenet. Genomics 17:283-290(2007) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Crystal structure of human type II inosine monophosphate dehydrogenase implications for ligand binding and drug design.Colby T.D., Vanderveen K., Strickler M.D., Markham G.D., Goldstein B.M.Proc. Natl. Acad. Sci. U.S.A. 96:3531-3536(1999) Crystal structure of human inosine monophosphate dehydrogenase type II complexed with the MPA/NAD analog C2-MAD.Risal D., Strickler M.D., Goldstein B.M.Submitted (DEC-2002) to the PDB data bankThe conformation of NAD bound to human inosine monophosphate Dehydrogenase Type II.Risal D., Strickler M.D., Goldstein B.M.Submitted (DEC-2002) to the PDB data bank
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 Research Articles on IMPD2    1. The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IMPD2 recombinant proteinPathways associated with IMPD2 recombinant protein
 Reference Product  PubMed Publications
 ITPA recombinant protein  >3 publications with IMPD2 and ITPA
 GMPS recombinant protein  >1 publications with IMPD2 and GMPS
 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
Diseases associated with IMPD2 recombinant proteinOrgans/Tissues associated with IMPD2 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >7 publications with IMPD2 and Liver Diseases
 Inflammation Antibodies  >5 publications with IMPD2 and Inflammation
 Kidney Diseases Antibodies  >4 publications with IMPD2 and Kidney Diseases
 Prostatic Diseases Antibodies  >3 publications with IMPD2 and Prostatic Diseases
 Adenocarcinoma Antibodies  >2 publications with IMPD2 and Adenocarcinoma
 Necrosis Antibodies  >2 publications with IMPD2 and Necrosis
 Anemia Antibodies  >1 publications with IMPD2 and Anemia
 Neoplasms, Experimental Antibodies  >1 publications with IMPD2 and Neoplasms, Experimental
 Fibrosis Antibodies  >1 publications with IMPD2 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with IMPD2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with IMPD2 and Blood
 Kidney Antibodies  >19 publications with IMPD2 and Kidney
 Prostate Antibodies  >5 publications with IMPD2 and Prostate
 Liver Antibodies  >5 publications with IMPD2 and Liver
 Bone Antibodies  >4 publications with IMPD2 and Bone
 Pancreas Antibodies  >2 publications with IMPD2 and Pancreas
 Eye Antibodies  >2 publications with IMPD2 and Eye
 Heart Antibodies  >2 publications with IMPD2 and Heart
 Testis Antibodies  >1 publications with IMPD2 and Testis
 Uterus Antibodies  >1 publications with IMPD2 and Uterus
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