NP_001069750.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
23,061 Da
NCBI Official Full Name
inosine triphosphate pyrophosphatase
NCBI Official Synonym Full Names
inosine triphosphatase
NCBI Protein Information
inosine triphosphate pyrophosphatase
UniProt Protein Name
Inosine triphosphate pyrophosphatase
UniProt Synonym Protein Names
Non-canonical purine NTP pyrophosphatase
UniProt Synonym Gene Names
UniProt Comments for ITPA
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
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Products associated with ITPA recombinant protein
Pathways associated with ITPA recombinant protein
Diseases associated with ITPA recombinant protein
Organs/Tissues associated with ITPA recombinant protein
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