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bIGF1 recombinant protein :: Insulin Like Growth Factor-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142303 bIGF1 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,900 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Like Growth Factor-1 (bIGF1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rabbit Insulin Like Growth Factor-1

 Product Synonym Names    IGF1 Rabbit; Insulin-Like Growth Factor 1 Rabbit Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Mechano growth factor; MGF
 Product Gene Name   

bIGF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MTAGPETLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKP
 3D Structure    ModBase 3D Structure for Q95222
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by: (a) Gel-filtration chromatography under non denaturing conditions. (b) Analysis by SDS-PAGE.
 Form/Format    The protein was lyophilized from a concentrated (0.5 mg/ml) solution with 0.02% NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized rbIGF-I in sterile 0.4% NaHCO3 adjusted, not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    IGF-I is biologically active when compared to human IGF-1. The ED50, calculated by the dose -dependent proliferation of human MCF/7 cells is 5 to 25ng/ml in the cell culture mixture dependent on culture conditions. Its activity consists of 30-40 % compared to human IGF-1.
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 Preparation and Storage    Lyophilized Insulin-Like Growth Factor-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IGF1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of bIGF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for bIGF1 recombinant protein

   Description: Insulin-Like Growth Factor-I Rabbit Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 7639 Dalton.

Introduction: The IGFs comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone. Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin'. Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A, and somatomedin B. IGF-1 is a small protein secreted mostly but not exclusively by the liver and circulating in blood mostly as a complex with several IGF binding proteins. It has growth-regulating, insulin-like, and mitogenic functions and it is secreted in response to growth hormone stimulation.
 Product Categories/Family for bIGF1 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Insulin-Like Growth Factor
NCBI/Uniprot data below describe general gene information for bIGF1. It may not necessarily be applicable to this product.
 NCBI GI #    126722801
 NCBI GeneID    100008668
 NCBI Accession #    NP_001075495.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001082026.1 [Other Products]
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 UniProt Primary Accession #    Q95222 [Other Products]
 UniProt Secondary Accession #    O18846 [Other Products]
 UniProt Related Accession #    Q95222 [Other Products]
 Molecular Weight    15,205 Da
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 NCBI Official Full Name    insulin-like growth factor I
 NCBI Official Symbol    IGF1 [Similar Products]
 NCBI Official Synonym Symbols   
IGF-IB
[Similar Products]
 NCBI Protein Information    insulin-like growth factor I; IGF-I; insulin-like growth factor IB; somatomedin
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
Somatomedin
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IGF-1; IGF-I [Similar Products]
 UniProt Entry Name    IGF1_RABIT
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 UniProt Comments for bIGF1    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().
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 Research Articles on bIGF1    1. Our studies demonstrate that the active SVCT2 is expressed in IVD cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with bIGF1 recombinant proteinDiseases associated with bIGF1 recombinant protein
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
 Disease Name  Pubmed Publications
 Acromegaly Antibodies  >129 publications with bIGF1 and Acromegaly
 Breast Neoplasms Antibodies  >112 publications with bIGF1 and Breast Neoplasms
 Inflammation Antibodies  >88 publications with bIGF1 and Inflammation
 Female Urogenital Diseases Antibodies  >87 publications with bIGF1 and Female Urogenital Diseases
 Liver Diseases Antibodies  >66 publications with bIGF1 and Liver Diseases
 Adenoma Antibodies  >59 publications with bIGF1 and Adenoma
 Prostatic Neoplasms Antibodies  >51 publications with bIGF1 and Prostatic Neoplasms
 Necrosis Antibodies  >45 publications with bIGF1 and Necrosis
 Pituitary Neoplasms Antibodies  >45 publications with bIGF1 and Pituitary Neoplasms
 Hypertension Antibodies  >39 publications with bIGF1 and Hypertension
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