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IGFBP5 recombinant protein :: Insulin Like Growth Factor Binding Protein-5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142340 IGFBP5 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Like Growth Factor Binding Protein-5 (IGFBP5), Recombinant Protein

 Also Known As   

Recombinant Human Insulin Like Growth Factor Binding Protein-5

 Product Synonym Names    IGFBP 5 Human; Insulin-Like Growth Factor Binding Protein-5 Human Recombinant; IGFBP-5; IBP-5; IGF-binding protein 5
 Product Gene Name   

IGFBP5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE
 OMIM    146734
 3D Structure    ModBase 3D Structure for P24593
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    IBP-5 was lyophilized from a concentrated (1mg/ml) solution containing 10mM sodium Citrate pH-3
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Insulin-Like Growth Factor Binding Protein-5 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50, calculated by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is < 0.4 ?g/ml, corresponding to a specific activity of > 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II.
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 Preparation and Storage    Lyophilized IBP5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IGFBP 5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of IGFBP5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGFBP5 recombinant protein

   Description: IGFBP5 Human Recombinant produced in E Coli is a single, non-glycosylated, homodimeric polypeptide chain containing 252 amino acids and having a molecular mass of 28.6 kDa. IGFBP5 is purified by proprietary chromatographic techniques.

Introduction: IGFBP5 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
 Product Categories/Family for IGFBP5 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; IGFBP
NCBI/Uniprot data below describe general gene information for IGFBP5. It may not necessarily be applicable to this product.
 NCBI GI #    10834982
 NCBI GeneID    3488
 NCBI Accession #    NP_000590.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000599.3 [Other Products]
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 UniProt Primary Accession #    P24593 [Other Products]
 UniProt Secondary Accession #    Q5U0A3 [Other Products]
 UniProt Related Accession #    P24593 [Other Products]
 Molecular Weight    30,570 Da
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 NCBI Official Full Name    insulin-like growth factor-binding protein 5
 NCBI Official Synonym Full Names    insulin-like growth factor binding protein 5
 NCBI Official Symbol    IGFBP5 [Similar Products]
 NCBI Official Synonym Symbols   
IBP5
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5
 UniProt Protein Name    Insulin-like growth factor-binding protein 5
 Protein Family    Insulin-like growth factor-binding protein
 UniProt Gene Name    IGFBP5 [Similar Products]
 UniProt Synonym Gene Names    IBP5; IBP-5; IGF-binding protein 5; IGFBP-5 [Similar Products]
 UniProt Entry Name    IBP5_HUMAN
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 UniProt Comments for IGFBP5    IGFBP5: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Protein type: Secreted, signal peptide; Secreted; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region

Molecular Function: protein binding; insulin-like growth factor I binding; fibronectin binding; insulin-like growth factor II binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; mammary gland involution; hair follicle morphogenesis; negative regulation of smooth muscle cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; glucose metabolic process; negative regulation of smooth muscle cell migration; signal transduction; glucose homeostasis; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; cellular protein metabolic process; negative regulation of translation; striated muscle cell differentiation; negative regulation of osteoblast differentiation; regulation of cell growth; skeletal muscle growth; negative regulation of cell migration
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 Research Articles on IGFBP5    1. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGFBP5 recombinant proteinPathways associated with IGFBP5 recombinant protein
 Reference Product  PubMed Publications
 IGF1 recombinant protein  >28 publications with IGFBP5 and IGF1
 PTH recombinant protein  >20 publications with IGFBP5 and PTH
 IGF2 recombinant protein  >16 publications with IGFBP5 and IGF2
 SERPINE1 recombinant protein  >7 publications with IGFBP5 and SERPINE1
 THBS1 recombinant protein  >4 publications with IGFBP5 and THBS1
 FHL2 recombinant protein  >4 publications with IGFBP5 and FHL2
 PAPPA recombinant protein  >3 publications with IGFBP5 and PAPPA
 FN1 recombinant protein  >3 publications with IGFBP5 and FN1
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with IGFBP5 recombinant proteinOrgans/Tissues associated with IGFBP5 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >51 publications with IGFBP5 and Carcinoma
 Breast Neoplasms Antibodies  >50 publications with IGFBP5 and Breast Neoplasms
 Nervous System Diseases Antibodies  >36 publications with IGFBP5 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >23 publications with IGFBP5 and Cardiovascular Diseases
 Inflammation Antibodies  >22 publications with IGFBP5 and Inflammation
 Necrosis Antibodies  >22 publications with IGFBP5 and Necrosis
 Brain Diseases Antibodies  >21 publications with IGFBP5 and Brain Diseases
 Prostatic Neoplasms Antibodies  >21 publications with IGFBP5 and Prostatic Neoplasms
 Atrophy Antibodies  >20 publications with IGFBP5 and Atrophy
 Neoplasms, Experimental Antibodies  >19 publications with IGFBP5 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >147 publications with IGFBP5 and Muscle
 Bone Antibodies  >127 publications with IGFBP5 and Bone
 Ovary Antibodies  >68 publications with IGFBP5 and Ovary
 Vascular Antibodies  >55 publications with IGFBP5 and Vascular
 Connective Tissue Antibodies  >54 publications with IGFBP5 and Connective Tissue
 Liver Antibodies  >52 publications with IGFBP5 and Liver
 Brain Antibodies  >50 publications with IGFBP5 and Brain
 Mammary Gland Antibodies  >46 publications with IGFBP5 and Mammary Gland
 Embryonic Tissue Antibodies  >42 publications with IGFBP5 and Embryonic Tissue
 Kidney Antibodies  >41 publications with IGFBP5 and Kidney
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