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IGFBP7 recombinant protein :: Insulin Like Growth Factor Binding Protein-7 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS146624 IGFBP7 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Like Growth Factor Binding Protein-7 (IGFBP7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Insulin Like Growth Factor Binding Protein-7

 Product Synonym Names    IGFBP7 Human; Insulin-Like Growth Factor Binding Protein-7 Human Recombinant; Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF; IGFBP7; MAC25; PSF; AGM; FSTL2; RAMSVPS; IGFBP-7v; IGFBPRP1
 Product Gene Name   

IGFBP7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV DALHEIPVKK GEGAEL
 OMIM    602867
 3D Structure    ModBase 3D Structure for Q16270
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 Purity/Purification    Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The IGFBP7 was lyophilized from a 0.2 um filtered concentrated solution in 20mM Tris-HCl, pH 8.5 and 150mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Source    E.coli
 Solubility    It is recommended to reconstitute the lyophilzed IGFBP-7 in sterile 20mM AcOH (acetic Acid) not less than 100ug/ml, which can then be further diluted to otehr aqueous solutions.
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 Preparation and Storage    Lyophilized IGFBP7 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IGFBP-7 should be stored at 4C between 2-7 days and for future use below -18C.
For long term storage it is recommended to add a carrier protein (0.1 HSA or BSA).
Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of IGFBP7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGFBP7 recombinant protein

   Description: Recombinant Human IGFBP7 produced in E Coli cells is a non-glycosylated, homodimeric protein containing 2 x 256 amino acid chains and having a molecular mass of 26.4kDa. The IGFBP-7 is purified by proprietary chromatographic techniques.

Introduction: Insulin-like Growth Factor-Binding Protein 7 (IGFBP7) is a member of the IGFBP family. IGFBP family members are all cysteine rich proteins with conserved cysteine and have an IGFBP domain, a Kazal-like domain and an Ig-like C2-type domain. IGFBP7 is expressed in a broad range of normal human tissues and it mostly shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. IGFBP7 has a role in skeletal myogenesis by binding to IGF in a manner which inhibits IGF induced differentiation of skeletal myoblasts, without disturbing IGF induced proliferation. Moreover, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines via an IGF independent mechanism, which triggers a delay in the G1 phase of the cell cycle, and increased apoptosis.
 Product Categories/Family for IGFBP7 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; IGFBP
NCBI/Uniprot data below describe general gene information for IGFBP7. It may not necessarily be applicable to this product.
 NCBI GI #    359465608
 NCBI GeneID    3490
 NCBI Accession #    NP_001240764.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001253835.1 [Other Products]
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 UniProt Primary Accession #    Q16270 [Other Products]
 UniProt Secondary Accession #    Q07822; Q53YE6; Q9UCA8; B4E1N2; B7Z9W7 [Other Products]
 UniProt Related Accession #    Q16270 [Other Products]
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 NCBI Official Full Name    insulin-like growth factor-binding protein 7 isoform 2
 NCBI Official Synonym Full Names    insulin-like growth factor binding protein 7
 NCBI Official Symbol    IGFBP7 [Similar Products]
 NCBI Official Synonym Symbols   
AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 7; IGF-binding protein 7; IGFBP-rP1; PGI2-stimulating factor; angiomodulin; prostacyclin-stimulating factor; tumor-derived adhesion factor
 UniProt Protein Name    Insulin-like growth factor-binding protein 7
 UniProt Synonym Protein Names   
IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF
 Protein Family    Insulin-like growth factor-binding protein
 UniProt Gene Name    IGFBP7 [Similar Products]
 UniProt Synonym Gene Names    MAC25; PSF; IBP-7; IGF-binding protein 7; IGFBP-7; TAF [Similar Products]
 UniProt Entry Name    IBP7_HUMAN
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 NCBI Summary for IGFBP7    This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
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 UniProt Comments for IGFBP7    IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

Protein type: Secreted; Cell cycle regulation; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; protein binding

Biological Process: negative regulation of cell proliferation; response to cortisol stimulus; response to retinoic acid; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus

Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis
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 Research Articles on IGFBP7    1. These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGFBP7 recombinant proteinPathways associated with IGFBP7 recombinant protein
 Reference Product  PubMed Publications
 IGF2 recombinant protein  >5 publications with IGFBP7 and IGF2
 IGF1 recombinant protein  >3 publications with IGFBP7 and IGF1
 VEGFA recombinant protein  >2 publications with IGFBP7 and VEGFA
 LIF recombinant protein  >2 publications with IGFBP7 and LIF
 TP53 recombinant protein  >2 publications with IGFBP7 and TP53
 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Senescence-Associated Secretory Phenotype (SASP) Pathway antibodies  Senescence-Associated Secretory Phenotype (SASP) Pathway Diagram
Diseases associated with IGFBP7 recombinant proteinOrgans/Tissues associated with IGFBP7 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >27 publications with IGFBP7 and Carcinoma
 Leukemia Antibodies  >14 publications with IGFBP7 and Leukemia
 Adenocarcinoma Antibodies  >14 publications with IGFBP7 and Adenocarcinoma
 Breast Neoplasms Antibodies  >12 publications with IGFBP7 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >11 publications with IGFBP7 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >9 publications with IGFBP7 and Cardiovascular Diseases
 Liver Diseases Antibodies  >7 publications with IGFBP7 and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >7 publications with IGFBP7 and Carcinoma, Squamous Cell
 Liver Neoplasms Antibodies  >7 publications with IGFBP7 and Liver Neoplasms
 Lung Neoplasms Antibodies  >6 publications with IGFBP7 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with IGFBP7 and Blood
 Vascular Antibodies  >20 publications with IGFBP7 and Vascular
 Brain Antibodies  >18 publications with IGFBP7 and Brain
 Skin Antibodies  >14 publications with IGFBP7 and Skin
 Embryonic Tissue Antibodies  >10 publications with IGFBP7 and Embryonic Tissue
 Kidney Antibodies  >8 publications with IGFBP7 and Kidney
 Lung Antibodies  >8 publications with IGFBP7 and Lung
 Muscle Antibodies  >8 publications with IGFBP7 and Muscle
 Liver Antibodies  >8 publications with IGFBP7 and Liver
 Heart Antibodies  >8 publications with IGFBP7 and Heart
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