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IGF1 recombinant protein :: Insulin-Like Growth Factor I (rHuIGF-I) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS197011 IGF1 recombinant protein
Unit / Price
0.02 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $280 +1 FREE 8GB USB
1 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin-Like Growth Factor I (rHuIGF-I) (IGF1), Recombinant Protein

 Also Known As   

Recombinant Human Insulin-Like Growth Factor I(rHuIGF-1)

 Product Synonym Names    Recombinant Human Insulin-Like Growth Factor I (rHuIGF-I)
 Product Gene Name   

IGF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (102789645..102874378, complement). Location: 12q23.2
 OMIM    147440. gene. :: 608747. phenotype.
 3D Structure    ModBase 3D Structure for P01343
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 Host    E Coli
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 Specificity    Recombinant Human Insulin-Like Growth Factor I (rHuIGF-I)
 Purity/Purification    Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic
 Form/Format    Sterile filtered, lyophilized.
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 Dimers/Aggregates    <1% by SDSPAGE
 Biological Activity    Fully biologically active compared to reference standards. Specific activity is 1 x 10^6 IU/mg. Biological activity at 0.2-20 ng/ml.
 Endotoxin Level    <0.1 ng/ug
 Protein Content    Determined spectrophotometrically at 280nm (0.502 ext. coeff), and by RP-HPLC analysis against a calibrated standard.
 Solubility    Reconstitute the lyophilized product in sterile water not less than 100 ug/ml. Product was dialyzed against 50mM acetate prior to lyophilization.
 Stabilizer    None
 Preservatives    None
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 Preparation and Storage    Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of IGF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGF1 recombinant protein

   Recombinant Human IGF-1 produced in E. coli is a single, non-glycosylated polypeptide chain containing 70 amino acids with a molecular mass of 7,655 daltons. This product has full biological activity.
 Product Categories/Family for IGF1 recombinant protein    Recombinant Proteins
NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
 NCBI GI #    184834
 NCBI GeneID    3479
 NCBI Accession #    AAA52789.1 [Other Products]
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 UniProt Primary Accession #    P01343 [Other Products]
 UniProt Related Accession #    P05019; Q13429; Q14620; Q59GC5; Q5U743; Q6LD41; Q9NP10 [Other Products]
 Molecular Weight    17,026 Da [Similar Products]
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 NCBI Official Full Name    insulin-like growth factor I
 NCBI Official Synonym Full Names    insulin-like growth factor 1 (somatomedin C)
 NCBI Official Symbol    IGF1 [Similar Products]
 NCBI Official Synonym Symbols   
IGFI; IGF-I; IGF1A
[Similar Products]
 NCBI Protein Information    insulin-like growth factor 1; MGF; IGF-IA; IGF-IB; somatomedin-C; OTTHUMP00000195080; OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083; OTTHUMP00000195084; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB
 UniProt Protein Name    Insulin-like growth factor 1 (Somatomedin C)
 UniProt Synonym Protein Names   
Somatomedin-C; Mechano growth factor; MGF
 Protein Family    Insulin-like growth factor
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IBP1 [Similar Products]
 UniProt Entry Name    Q5U743_HUMAN
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 NCBI Summary for IGF1    The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
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 UniProt Comments for IGF1    IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region; plasma membrane

Molecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding

Biological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; glycolate metabolic process; exocrine pancreas development; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of mitosis; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; branching morphogenesis of a tube; regulation of gene expression; response to heat; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of smooth muscle cell proliferation; myoblast proliferation; positive regulation of glycogen biosynthetic process; signal transduction; positive regulation of activated T cell proliferation; positive regulation of smooth muscle cell migration; negative regulation of cell proliferation; platelet degranulation; glial cell differentiation; positive regulation of MAPKKK cascade; mammary gland development; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; regulation of multicellular organism growth; myotube cell development; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; cell proliferation; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; Ras protein signal transduction; positive regulation of glycolysis; blood vessel remodeling; positive regulation of Ras protein signal transduction; cell motility; blood coagulation; positive regulation of DNA replication

Disease: Insulin-like Growth Factor I Deficiency
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 Research Articles on IGF1    1. This study suggested that polymorphisms within the IGF-I gene could infer greater risk for Alzheimer disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF1 recombinant proteinPathways associated with IGF1 recombinant protein
 Reference Product  PubMed Publications
 IGF1R recombinant protein  >211 publications with IGF1 and IGF1R
 IGFBP3 recombinant protein  >133 publications with IGF1 and IGFBP3
 IGFBP1 recombinant protein  >41 publications with IGF1 and IGFBP1
 IGFBP2 recombinant protein  >25 publications with IGF1 and IGFBP2
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with IGF1 recombinant proteinOrgans/Tissues associated with IGF1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >260 publications with IGF1 and Neoplasms
 Insulin Resistance Antibodies  >116 publications with IGF1 and Insulin Resistance
 INSULIN-LIKE GROWTH FACTOR I DEFICIENCY Antibodies  >78 publications with IGF1 and INSULIN-LIKE GROWTH FACTOR I DEFICIENCY
 Breast Neoplasms Antibodies  >71 publications with IGF1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >69 publications with IGF1 and Cardiovascular Diseases
 Acromegaly Antibodies  >69 publications with IGF1 and Acromegaly
 Female Urogenital Diseases Antibodies  >49 publications with IGF1 and Female Urogenital Diseases
 Hypertrophy Antibodies  >37 publications with IGF1 and Hypertrophy
 Adenoma Antibodies  >34 publications with IGF1 and Adenoma
 Liver Diseases Antibodies  >32 publications with IGF1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >324 publications with IGF1 and Blood
 Muscle Antibodies  >154 publications with IGF1 and Muscle
 Liver Antibodies  >132 publications with IGF1 and Liver
 Bone Antibodies  >123 publications with IGF1 and Bone
 Brain Antibodies  >111 publications with IGF1 and Brain
 Ovary Antibodies  >67 publications with IGF1 and Ovary
 Vascular Antibodies  >66 publications with IGF1 and Vascular
 Connective Tissue Antibodies  >59 publications with IGF1 and Connective Tissue
 Heart Antibodies  >53 publications with IGF1 and Heart
 Nerve Antibodies  >49 publications with IGF1 and Nerve
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