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IGF-I recombinant protein :: Insulin Like Growth Factor-I Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553053 IGF-I recombinant protein
Unit / Price
0.02 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Like Growth Factor-I (IGF-I), Recombinant Protein

 Also Known As   

Human Insulin Like Growth Factor-I Recombinant

 Product Synonym Names    igf-1; insulin like; igf1; igf-i
 Product Gene Name   

IGF-I recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KTQKEVHLKN ASRGSAGNKN YRM
 OMIM    147440
 3D Structure    ModBase 3D Structure for P01343
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 Host    E Coli
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 Purity/Purification    >95%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Human IGF1 was lyophilized from a 0.2 um filtered PBS solution, pH 7.4.
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 Domain    Insulin
 Host Note    Optimized DNA sequence encoding Human Insulin Growth Factor -1mature chain was expressed in Escherichia Coli.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Native Human Insulin Growth Factor-1 is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 8 kDa.
Recombinant Human IGF-1 is a disulfide-linked monomeric protein consisting of 71 amino acid residue subunits. IGF-1 migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IGF-I recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IGF-I recombinant protein

   Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-I is synthesized as two precursor isoforms with N- and alternate C- terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C- terminal regions. Mature human IGF-I shares 94% and 96% aa sequence identity with mouse and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects.
 Product Categories/Family for IGF-I recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for IGF-I. It may not necessarily be applicable to this product.
 NCBI GI #    11024682
 NCBI GeneID    3479
 NCBI Accession #    NP_000609.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000618.3 [Other Products]
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 UniProt Primary Accession #    P01343 [Other Products]
 UniProt Secondary Accession #    P01343; Q14620; B2RWM7 [Other Products]
 UniProt Related Accession #    P05019; Q13429; Q14620; Q59GC5; Q5U743; Q6LD41; Q9NP10 [Other Products]
 Molecular Weight    21,841 Da
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 NCBI Official Full Name    insulin-like growth factor 1 isoform 4 preproprotein
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
Mechano growth factor; MGF; Somatomedin-C
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IBP1; IGF-I; MGF [Similar Products]
 UniProt Entry Name    IGF1_HUMAN
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 NCBI Summary for IGF-I    The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
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 UniProt Comments for IGF-I    IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; plasma membrane; extracellular region

Molecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding

Biological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; glycolate metabolic process; exocrine pancreas development; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of mitosis; positive regulation of protein import into nucleus, translocation; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; branching morphogenesis of a tube; response to heat; regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; myoblast proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of glycogen biosynthetic process; signal transduction; positive regulation of activated T cell proliferation; positive regulation of smooth muscle cell migration; negative regulation of cell proliferation; glial cell differentiation; platelet degranulation; positive regulation of MAPKKK cascade; mammary gland development; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; regulation of multicellular organism growth; myotube cell development; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; positive regulation of protein kinase B signaling cascade; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; Ras protein signal transduction; positive regulation of glycolysis; blood vessel remodeling; positive regulation of Ras protein signal transduction; cell motility; blood coagulation; positive regulation of DNA replication

Disease: Insulin-like Growth Factor I Deficiency
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Product References and Citations for IGF-I recombinant protein

   statement by the growth hormone research society on the gh/IGF-I axis in extending health span .J Gerontol A Biol Sci Med Sci, Oct 2009; 64A: 1039 - 1044.
partial primary deficiency of insulin-like growth factor (igf) -i activity associated with igf1 mutation demonstrates its critical role in growth and brain development .J. Clin. Endocrinol. Metab., Sep 2009; 10.1210/jc.2009-0452.
myostatin inhibits IGF-I induced myotube hypertrophy through akt .Am J Physiol Cell Physiol, Sep 2009; 10.1152/ajpcell.00043.2009.
the insulin-like growth factor (igf) -i e-peptides modulate cell entry of the mature IGF-I protein .Mol. Biol. Cell, Sep 2009; 20: 3810 - 3817.
elevated levels of insulin-like growth factor (igf) -i in serum rescue the severe growth retardation of IGF-I null mice .Endocrinology, Sep 2009; 150: 4395 - 4403.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF-I recombinant proteinPathways associated with IGF-I recombinant protein
 Reference Product  PubMed Publications
 IGF1R recombinant protein  >211 publications with IGF-I and IGF1R
 IGFBP3 recombinant protein  >133 publications with IGF-I and IGFBP3
 IGFBP1 recombinant protein  >41 publications with IGF-I and IGFBP1
 IGFBP2 recombinant protein  >25 publications with IGF-I and IGFBP2
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with IGF-I recombinant proteinOrgans/Tissues associated with IGF-I recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >260 publications with IGF-I and Neoplasms
 Insulin Resistance Antibodies  >116 publications with IGF-I and Insulin Resistance
 INSULIN-LIKE GROWTH FACTOR I DEFICIENCY Antibodies  >78 publications with IGF-I and INSULIN-LIKE GROWTH FACTOR I DEFICIENCY
 Breast Neoplasms Antibodies  >71 publications with IGF-I and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >69 publications with IGF-I and Cardiovascular Diseases
 Acromegaly Antibodies  >69 publications with IGF-I and Acromegaly
 Female Urogenital Diseases Antibodies  >49 publications with IGF-I and Female Urogenital Diseases
 Hypertrophy Antibodies  >37 publications with IGF-I and Hypertrophy
 Adenoma Antibodies  >34 publications with IGF-I and Adenoma
 Liver Diseases Antibodies  >32 publications with IGF-I and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >324 publications with IGF-I and Blood
 Muscle Antibodies  >154 publications with IGF-I and Muscle
 Liver Antibodies  >132 publications with IGF-I and Liver
 Bone Antibodies  >123 publications with IGF-I and Bone
 Brain Antibodies  >111 publications with IGF-I and Brain
 Ovary Antibodies  >67 publications with IGF-I and Ovary
 Vascular Antibodies  >66 publications with IGF-I and Vascular
 Connective Tissue Antibodies  >59 publications with IGF-I and Connective Tissue
 Heart Antibodies  >53 publications with IGF-I and Heart
 Nerve Antibodies  >49 publications with IGF-I and Nerve
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