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IGF2 recombinant protein :: Insulin-Like Growth Factor II (rHuIGF-II) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS197012 IGF2 recombinant protein
Unit / Price
0.01 mg  /  $195 +1 FREE 8GB USB
0.05 mg  /  $280 +1 FREE 8GB USB
1 mg  /  $1,675 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin-Like Growth Factor II (rHuIGF-II) (IGF2), Recombinant Protein

 Also Known As   

Recombinant Human Insulin-Like Growth Factor II(rHuIGF-II)

 Product Synonym Names    Recombinant Human Insulin-Like Growth Factor II (rHuIGF-II)
 Product Gene Name   

IGF2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (2150347..2170833, complement). Location: 11p15.5
 OMIM    147470
 3D Structure    ModBase 3D Structure for P01344
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 Host    E Coli
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 Specificity    Recombinant Human Insulin-Like Growth Factor II (rHuIGF-II)
 Purity/Purification    Greater than 97% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain.
Purification: Chromatographic
 Form/Format    Sterile filtered, lyophilized.
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 Dimers/Aggregates    <1% by SDSPAGE
 Biological Activity    Fully biologically active compared to reference standards. Specific activity is 1 x 10^6 IU/mg.
 Endotoxin Level    <0.1 ng/ug
 Protein Content    Determined spectrophotometrically at 280nm and by RP-HPLC analysis against a calibrated standard.
 Solubility    Reconstitute the lyophilized product in sterile water not less than 100 ug/ml.
 Stabilizer    None
 Preservatives    None
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 Preparation and Storage    Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of IGF2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGF2 recombinant protein

   Recombinant Human IGF-II produced in E. coli is a single, non-glycosylated polypeptide chain containing 67 amino acids with a molecular mass of 7,505 daltons. This product has full biological activity.
 Product Categories/Family for IGF2 recombinant protein    Recombinant Proteins
NCBI/Uniprot data below describe general gene information for IGF2. It may not necessarily be applicable to this product.
 NCBI GI #    189083846
 NCBI GeneID    3481
 NCBI Accession #    NP_001121070.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127598.1 [Other Products]
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 UniProt Primary Accession #    P01344 [Other Products]
 UniProt Secondary Accession #    P78449; Q14299; Q1WM26; Q9UC68; Q9UC69; B3KX48; B7WP08 [Other Products]
 UniProt Related Accession #    P01344 [Other Products]
 Molecular Weight    20,140 Da [Similar Products]
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 NCBI Official Full Name    insulin-like growth factor II isoform 2
 NCBI Official Synonym Full Names    insulin-like growth factor 2 (somatomedin A)
 NCBI Official Symbol    IGF2 [Similar Products]
 NCBI Official Synonym Symbols   
IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734
[Similar Products]
 NCBI Protein Information    insulin-like growth factor II; somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015; OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158; OTTHUMP00000220677; insulin-like growth factor type 2
 UniProt Protein Name    Insulin-like growth factor II
 UniProt Synonym Protein Names   
Somatomedin-A
 Protein Family    Insulin-like growth factor
 UniProt Gene Name    IGF2 [Similar Products]
 UniProt Entry Name    IGF2_HUMAN
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 NCBI Summary for IGF2    This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for IGF2    IGF2: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: protein serine/threonine kinase activator activity; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding; receptor activator activity

Biological Process: positive regulation of catalytic activity; response to nicotine; genetic imprinting; multicellular organismal development; positive regulation of glycogen biosynthetic process; exocrine pancreas development; female pregnancy; positive regulation of activated T cell proliferation; response to estradiol stimulus; response to radiation; platelet degranulation; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; skeletal development; response to drug; response to nutrient levels; platelet activation; positive regulation of mitosis; glucose metabolic process; memory; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; cellular protein metabolic process; insulin receptor signaling pathway; striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of insulin receptor signaling pathway; blood coagulation

Disease: Silver-russell Syndrome; Growth Restriction, Severe, With Distinctive Facies; Beckwith-wiedemann Syndrome; Wilms Tumor 1
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 Research Articles on IGF2    1. IGF1 might inhibit insulinogenic differentiation of HEAC, whereas IGF2 enhances differentiation, and enhancement of IGF2 appears to be mediated via IR
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF2 recombinant proteinPathways associated with IGF2 recombinant protein
 Reference Product  PubMed Publications
 IGF2R recombinant protein  >151 publications with IGF2 and IGF2R
 IGF1R recombinant protein  >88 publications with IGF2 and IGF1R
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with IGF2 recombinant proteinOrgans/Tissues associated with IGF2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >521 publications with IGF2 and Neoplasms
 Carcinoma Antibodies  >164 publications with IGF2 and Carcinoma
 Female Urogenital Diseases Antibodies  >149 publications with IGF2 and Female Urogenital Diseases
 Congenital Abnormalities Antibodies  >137 publications with IGF2 and Congenital Abnormalities
 Male Urogenital Diseases Antibodies  >130 publications with IGF2 and Male Urogenital Diseases
 Kidney Diseases Antibodies  >103 publications with IGF2 and Kidney Diseases
 Kidney Neoplasms Antibodies  >100 publications with IGF2 and Kidney Neoplasms
 Growth Disorders Antibodies  >90 publications with IGF2 and Growth Disorders
 Liver Neoplasms Antibodies  >89 publications with IGF2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >87 publications with IGF2 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >180 publications with IGF2 and Embryonic Tissue
 Kidney Antibodies  >123 publications with IGF2 and Kidney
 Placenta Antibodies  >108 publications with IGF2 and Placenta
 Brain Antibodies  >76 publications with IGF2 and Brain
 Lung Antibodies  >49 publications with IGF2 and Lung
 Pancreas Antibodies  >28 publications with IGF2 and Pancreas
 Eye Antibodies  >9 publications with IGF2 and Eye
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