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PP1446 recombinant protein :: Insulin-like growth factor II Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717318
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $295 +1 FREE 8GB USB
0.5 mg  /  $580 +1 FREE 8GB USB
1 mg  /  $855 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin-like growth factor II (PP1446), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Insulin-like growth factor II protein

 Product Synonym Names    Somatomedin-AT3; M-11-derived growth factor
 Product Gene Name   

PP1446 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS717318 COA    COA PDF
 Sequence Positions    30-180aa; Partial
 Sequence    ETLCGGELVD TLQFVCGDRG FYFSRPASRV SRRSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTPPT VLPDNFPRYP VGKFFQYDTW KQSTQRLRRG LPALLRARRG HVLAKELEAF REAKRHRPLI ALPTQDPAHG GAPPEMASNR K
 OMIM    147470
 3D Structure    ModBase 3D Structure for P01344
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PP1446 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PP1446 recombinant protein

   The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
 Product Categories/Family for PP1446 recombinant protein    Metabolism
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 SDS-PAGE of PP1446 recombinant protein    PP1446 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PP1446. It may not necessarily be applicable to this product.
 NCBI GI #    4504609
 NCBI GeneID    3481
 NCBI Accession #    NP_000603.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000612.5 [Other Products]
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 UniProt Primary Accession #    P01344 [Other Products]
 UniProt Secondary Accession #    P78449; Q14299; Q1WM26; Q9UC68; Q9UC69; B3KX48; B7WP08; C9JAF2; E3UN45 [Other Products]
 UniProt Related Accession #    P01344 [Other Products]
 Molecular Weight    44.5kD
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 NCBI Official Full Name    insulin-like growth factor II isoform 1 preproprotein
 NCBI Official Synonym Full Names    insulin like growth factor 2
 NCBI Official Symbol    IGF2 [Similar Products]
 NCBI Official Synonym Symbols   
GRDF; IGF-II; PP9974; C11orf43
[Similar Products]
 NCBI Protein Information    insulin-like growth factor II
 UniProt Protein Name    Insulin-like growth factor II
 UniProt Synonym Protein Names   
Somatomedin-A; T3M-11-derived growth factor
 Protein Family    Insulin-like growth factor
 UniProt Gene Name    IGF2 [Similar Products]
 UniProt Synonym Gene Names    IGF-II [Similar Products]
 UniProt Entry Name    IGF2_HUMAN
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 NCBI Summary for PP1446    This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
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 UniProt Comments for PP1446    IGF2: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function: growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; protein binding; protein serine/threonine kinase activator activity; receptor activator activity

Biological Process: blood coagulation; cellular protein metabolic process; exocrine pancreas development; female pregnancy; genetic imprinting; glucose metabolic process; insulin receptor signaling pathway; memory; multicellular organismal development; negative regulation of natural killer cell mediated cytotoxicity; organ morphogenesis; ossification; platelet activation; platelet degranulation; positive regulation of activated T cell proliferation; positive regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of MAPKKK cascade; positive regulation of mitosis; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to drug; response to estradiol stimulus; response to ethanol; response to nicotine; response to nutrient levels; response to radiation; skeletal development; striated muscle cell differentiation

Disease: Beckwith-wiedemann Syndrome; Growth Restriction, Severe, With Distinctive Facies; Silver-russell Syndrome; Wilms Tumor 1
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Product References and Citations for PP1446 recombinant protein

   Insulin-like growth factor II precursor gene organization in relation to insulin gene family.Dull T.J., Gray A., Hayflick J.S., Ullrich A.Nature 310:777-781(1984)
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 Research Articles on PP1446    1. SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PP1446 recombinant proteinPathways associated with PP1446 recombinant protein
 Reference Product  PubMed Publications
 IGF2R recombinant protein  >264 publications with PP1446 and IGF2R
 IGF1R recombinant protein  >208 publications with PP1446 and IGF1R
 IGFBP3 recombinant protein  >83 publications with PP1446 and IGFBP3
 IGFBP2 recombinant protein  >62 publications with PP1446 and IGFBP2
 IGFBP1 recombinant protein  >42 publications with PP1446 and IGFBP1
 IGF2BP2 recombinant protein  >22 publications with PP1446 and IGF2BP2
 IGFBP5 recombinant protein  >22 publications with PP1446 and IGFBP5
 IGFBP6 recombinant protein  >15 publications with PP1446 and IGFBP6
 VEGFA recombinant protein  >13 publications with PP1446 and VEGFA
 GPC3 recombinant protein  >10 publications with PP1446 and GPC3
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
Diseases associated with PP1446 recombinant proteinOrgans/Tissues associated with PP1446 recombinant protein
 Disease Name  Pubmed Publications
 Beckwith-Wiedemann Syndrome Antibodies  >156 publications with PP1446 and Beckwith-Wiedemann Syndrome
 Growth Disorders Antibodies  >154 publications with PP1446 and Growth Disorders
 Wilms Tumor Antibodies  >146 publications with PP1446 and Wilms Tumor
 Liver Neoplasms Antibodies  >123 publications with PP1446 and Liver Neoplasms
 Liver Diseases Antibodies  >122 publications with PP1446 and Liver Diseases
 Colorectal Neoplasms Antibodies  >121 publications with PP1446 and Colorectal Neoplasms
 Kidney Diseases Antibodies  >119 publications with PP1446 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >86 publications with PP1446 and Carcinoma, Hepatocellular
 Obesity Antibodies  >77 publications with PP1446 and Obesity
 Breast Neoplasms Antibodies  >76 publications with PP1446 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >331 publications with PP1446 and Blood
 Muscle Antibodies  >310 publications with PP1446 and Muscle
 Liver Antibodies  >259 publications with PP1446 and Liver
 Embryonic Tissue Antibodies  >235 publications with PP1446 and Embryonic Tissue
 Placenta Antibodies  >182 publications with PP1446 and Placenta
 Brain Antibodies  >152 publications with PP1446 and Brain
 Kidney Antibodies  >150 publications with PP1446 and Kidney
 Bone Antibodies  >150 publications with PP1446 and Bone
 Lung Antibodies  >86 publications with PP1446 and Lung
 Heart Antibodies  >82 publications with PP1446 and Heart
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