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Irs1 recombinant protein :: Insulin receptor substrate 1 (Irs1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948487 Irs1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $900 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $900 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,125 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,125 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,250 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,250 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,695 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,695 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin receptor substrate 1 (Irs1), Recombinant Protein

 Also Known As   

Recombinant Rat Insulin receptor substrate 1 (Irs1) , partial

 Product Gene Name   

Irs1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P35570
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Irs1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Irs1 recombinant protein

   This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
NCBI/Uniprot data below describe general gene information for Irs1. It may not necessarily be applicable to this product.
 NCBI GI #    6981106
 NCBI GeneID    25467
 NCBI Accession #    NP_037101.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012969.1 [Other Products]
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 UniProt Primary Accession #    P35570 [Other Products]
 UniProt Related Accession #    P35570 [Other Products]
 Molecular Weight    131,178 Da
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 NCBI Official Full Name    insulin receptor substrate 1
 NCBI Official Synonym Full Names    insulin receptor substrate 1
 NCBI Official Symbol    Irs1 [Similar Products]
 NCBI Official Synonym Symbols   
IRS1IRM
[Similar Products]
 NCBI Protein Information    insulin receptor substrate 1
 UniProt Protein Name    Insulin receptor substrate 1
 UniProt Synonym Protein Names   
pp185
 Protein Family    Isoleucine--tRNA ligase
 UniProt Gene Name    Irs1 [Similar Products]
 UniProt Synonym Gene Names    Irs-1; IRS-1 [Similar Products]
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 NCBI Summary for Irs1    a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD, Feb 2006]
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 UniProt Comments for Irs1    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
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 Research Articles on Irs1    1. This study determined if dietary restriction (DR) protects against hypoxic-ischemia (HI) in the neonatal brain via insulin receptor substrate-1 (IRS-1)/Akt pathway-mediated downregulation of p53 in the neurovascular unit.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Irs1 recombinant proteinPathways associated with Irs1 recombinant protein
 Reference Product  PubMed Publications
 Igf1r recombinant protein  >240 publications with Irs1 and Igf1r
 Mtor recombinant protein  >139 publications with Irs1 and Mtor
 Grb2 recombinant protein  >138 publications with Irs1 and Grb2
 Jak2 recombinant protein  >62 publications with Irs1 and Jak2
 Insr recombinant protein  >52 publications with Irs1 and Insr
 Socs3 recombinant protein  >40 publications with Irs1 and Socs3
 Ptpn1 recombinant protein  >30 publications with Irs1 and Ptpn1
 Crk recombinant protein  >12 publications with Irs1 and Crk
 Pik3r1 recombinant protein  >12 publications with Irs1 and Pik3r1
 Pik3r2 recombinant protein  >1 publications with Irs1 and Pik3r2
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
Diseases associated with Irs1 recombinant proteinOrgans/Tissues associated with Irs1 recombinant protein
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >1219 publications with Irs1 and Insulin Resistance
 Hyperinsulinism Antibodies  >828 publications with Irs1 and Hyperinsulinism
 Diabetes Mellitus Antibodies  >489 publications with Irs1 and Diabetes Mellitus
 Obesity Antibodies  >413 publications with Irs1 and Obesity
 Diabetes Mellitus, Type 2 Antibodies  >334 publications with Irs1 and Diabetes Mellitus, Type 2
 Disease Models, Animal Antibodies  >199 publications with Irs1 and Disease Models, Animal
 Hyperglycemia Antibodies  >179 publications with Irs1 and Hyperglycemia
 Necrosis Antibodies  >176 publications with Irs1 and Necrosis
 Liver Diseases Antibodies  >134 publications with Irs1 and Liver Diseases
 Inflammation Antibodies  >133 publications with Irs1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >742 publications with Irs1 and Muscle
 Liver Antibodies  >388 publications with Irs1 and Liver
 Connective Tissue Antibodies  >212 publications with Irs1 and Connective Tissue
 Pancreas Antibodies  >127 publications with Irs1 and Pancreas
 Ovary Antibodies  >99 publications with Irs1 and Ovary
 Heart Antibodies  >94 publications with Irs1 and Heart
 Brain Antibodies  >89 publications with Irs1 and Brain
 Kidney Antibodies  >85 publications with Irs1 and Kidney
 Nerve Antibodies  >40 publications with Irs1 and Nerve
 Bone Antibodies  >34 publications with Irs1 and Bone
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