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ITGaM recombinant protein :: Integrin Alpha M Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2030077 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $290 +1 FREE 8GB USB
0.1 mg  /  $455 +1 FREE 8GB USB
0.2 mg  /  $560 +1 FREE 8GB USB
0.5 mg  /  $1,080 +1 FREE 8GB USB
1 mg  /  $1,610 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin Alpha M (ITGaM), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Integrin Alpha M (ITGaM)

 Product Gene Name   

ITGaM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the target protein is listed below.
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM SQEGFSAAIT SNGPLLST VG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG T
 OMIM    120980
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
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 Predicted isoelectric point    6.8
 Predicted Molecular Mass    18.2kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    N-terminal His-Tag
 Organism Species    Homo sapiens (Human)
 Fragment    Arg48~Pro245
 Usage    Reconstitute in sterile ddH2O.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ITGaM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ITGaM recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of ITGaM recombinant protein    ITGaM recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for ITGaM. It may not necessarily be applicable to this product.
 NCBI GI #    224831239
 NCBI GeneID    3684
 NCBI Accession #    NP_001139280.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145808.1 [Other Products]
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 UniProt Secondary Accession #    Q4VAK0; Q4VAK1; Q4VAK2 [Other Products]
 UniProt Related Accession #    P11215 [Other Products]
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 NCBI Official Full Name    integrin alpha-M isoform 1
 NCBI Official Synonym Full Names    integrin, alpha M (complement component 3 receptor 3 subunit)
 NCBI Official Symbol    ITGAM [Similar Products]
 NCBI Official Synonym Symbols   
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
[Similar Products]
 NCBI Protein Information    integrin alpha-M
 UniProt Protein Name    Integrin alpha-M
 UniProt Synonym Protein Names   
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b
 Protein Family    Integrin
 UniProt Gene Name    ITGAM [Similar Products]
 UniProt Synonym Gene Names    CD11B; CR3A [Similar Products]
 UniProt Entry Name    ITAM_HUMAN
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 NCBI Summary for ITGaM    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for ITGaM    ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; plasma membrane; nucleus; integrin complex; external side of plasma membrane

Molecular Function: heparin binding; heparan sulfate proteoglycan binding; opsonin binding; protein binding; protein heterodimerization activity; metal ion binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; leukocyte migration; toll-like receptor 4 signaling pathway

Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
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 Research Articles on ITGaM    1. A novel association of common variable immunodeficiency have been found with rare variants at the FUS/ITGAM (CD11b) locus on 16p11.2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ITGaM recombinant proteinPathways associated with ITGaM recombinant protein
 Reference Product  PubMed Publications
 ITGB2 recombinant protein  >1657 publications with ITGaM and ITGB2
 TNF recombinant protein  >678 publications with ITGaM and TNF
 ICAM1 recombinant protein  >445 publications with ITGaM and ICAM1
 PTPRC recombinant protein  >39 publications with ITGaM and PTPRC
 ICAM2 recombinant protein  >20 publications with ITGaM and ICAM2
 PLAUR recombinant protein  >15 publications with ITGaM and PLAUR
 THY1 recombinant protein  >15 publications with ITGaM and THY1
 SELP recombinant protein  >7 publications with ITGaM and SELP
 GP1BA recombinant protein  >1 publications with ITGaM and GP1BA
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with ITGaM recombinant proteinOrgans/Tissues associated with ITGaM recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1480 publications with ITGaM and Inflammation
 Disease Models, Animal Antibodies  >885 publications with ITGaM and Disease Models, Animal
 Necrosis Antibodies  >847 publications with ITGaM and Necrosis
 Nervous System Diseases Antibodies  >676 publications with ITGaM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >534 publications with ITGaM and Cardiovascular Diseases
 Brain Diseases Antibodies  >463 publications with ITGaM and Brain Diseases
 Neoplasms, Experimental Antibodies  >189 publications with ITGaM and Neoplasms, Experimental
 Heart Diseases Antibodies  >167 publications with ITGaM and Heart Diseases
 Atherosclerosis Antibodies  >132 publications with ITGaM and Atherosclerosis
 Liver Diseases Antibodies  >131 publications with ITGaM and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4646 publications with ITGaM and Blood
 Bone Antibodies  >886 publications with ITGaM and Bone
 Bone Marrow Antibodies  >824 publications with ITGaM and Bone Marrow
 Brain Antibodies  >671 publications with ITGaM and Brain
 Lung Antibodies  >561 publications with ITGaM and Lung
 Spleen Antibodies  >536 publications with ITGaM and Spleen
 Lymph Node Antibodies  >321 publications with ITGaM and Lymph Node
 Nerve Antibodies  >256 publications with ITGaM and Nerve
 Intestine Antibodies  >167 publications with ITGaM and Intestine
 Kidney Antibodies  >144 publications with ITGaM and Kidney
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