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Itgb1 recombinant protein :: Integrin beta-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS954230
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin beta-1 (Itgb1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Integrin beta-1

 Product Synonym Names    Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD29
 Product Gene Name   

Itgb1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS954230 COA    COA PDF
 Sequence Positions    21-729. Partial, provide the complete extracellular domain.
 Sequence    QTDKNRCLKA NAKSCGECIQ AGPNCGWCTN TTFLQEGMPT SARCDDLEAL KKKGCHPSDI ENPRGSQTIK KNKNVTNRSK GMAEKLRPED ITQIQPQQLL LKLRSGEPQK FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTDRGE FFNELVGQQR ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ CHLENNVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL SGNSSNVIQL IIDAYNSLSS EVILENSKLP DGVTINYKSY CKNGVNGTGE NGRKCSNISI GDEVQFEISI TANKCPNKES ENQLKLNPLG FTEEVEVVLQ FICKCNCQSH GIPASPKCHE GNGTFECGAC RCNEGRVGRH CECSTDEVNS EDMDAYCRKE NSSEICSNNG ECVCGQCVCR KRENTNEIYS GKFCECDNFN CDRSNGLICG GNGVCRCRVC ECYPNYTGSA CDCSLDTVPC VATNGQICNG RGICECGACK CTDPKFQGPT CETCQTCLGV CAEHKECVQC RAFNKGEKKD TCAQECSHFN LTKVESREKL PQPVQVDPVT HCKEKDIDDC WFYFTYSVNS KGEAHVHVVE TPDCPTGPD
 3D Structure    ModBase 3D Structure for P49134
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Itgb1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Itgb1 recombinant protein

   Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
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 SDS-PAGE of Itgb1 recombinant protein    Itgb1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Itgb1. It may not necessarily be applicable to this product.
 NCBI GI #    158303324
 NCBI GeneID    24511
 NCBI Accession #    NP_058718.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_017022.2 [Other Products]
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 UniProt Primary Accession #    P49134 [Other Products]
 UniProt Secondary Accession #    A2RRT8 [Other Products]
 UniProt Related Accession #    P49134 [Other Products]
 Molecular Weight    94.4kD
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 NCBI Official Full Name    integrin beta-1
 NCBI Official Synonym Full Names    integrin subunit beta 1
 NCBI Official Symbol    Itgb1 [Similar Products]
 NCBI Protein Information    integrin beta-1
 UniProt Protein Name    Integrin beta-1
 UniProt Synonym Protein Names   
Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD_antigen: CD29
 Protein Family    Integrin
 UniProt Gene Name    Itgb1 [Similar Products]
 UniProt Synonym Gene Names    Beta OL [Similar Products]
 UniProt Entry Name    ITB1_RAT
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 NCBI Summary for Itgb1    beta subunit of integrin receptor which binds collagen [RGD, Feb 2006]
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 UniProt Comments for Itgb1    ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).

Protein type: Membrane protein, integral; Cell surface; Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis

Cellular Component: acrosome; adherens junction; basement membrane; cell surface; cytoplasm; cytoplasmic vesicle; dendritic spine; external side of plasma membrane; filopodium; focal adhesion; hemidesmosome; integrin complex; intercellular junction; lamellipodium; lipid raft; melanosome; membrane; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; receptor complex; recycling endosome; sarcolemma; synapse

Molecular Function: actin binding; alpha-actinin binding; cell adhesion molecule binding; collagen binding; fibronectin binding; glycoprotein binding; integrin binding; kinase binding; laminin binding; metal ion binding; peptide binding; protease binding; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor binding

Biological Process: axon extension; calcium-independent cell-matrix adhesion; cardiac muscle cell differentiation; cardiac muscle development; cell adhesion; cell fate specification; cell migration; cell migration during sprouting angiogenesis; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular calcium ion homeostasis; dendrite morphogenesis; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; in utero embryonic development; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte tethering or rolling; maternal process involved in pregnancy; mesodermal cell differentiation; negative regulation of cell differentiation; negative regulation of cell projection organization and biogenesis; negative regulation of cell proliferation; negative regulation of neuron differentiation; negative regulation of Rho protein signal transduction; neurite development; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; positive regulation of peptidyl-tyrosine phosphorylation; protein transport within lipid bilayer; receptor internalization; regulation of cell cycle; regulation of G-protein coupled receptor protein signaling pathway; response to activity; response to drug; response to nutrient levels; sarcomere organization; stress fiber formation; tissue homeostasis; transforming growth factor beta receptor signaling pathway; visual learning
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Product References and Citations for Itgb1 recombinant protein

   Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit.Malek-Hedayat S., Rome L.H.Gene 158:287-290(1995)
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 Research Articles on Itgb1    1. Integrin-beta1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Itgb1 recombinant proteinPathways associated with Itgb1 recombinant protein
 Reference Product  PubMed Publications
 Itga6 recombinant protein  >16 publications with Itgb1 and Itga6
 Itgav recombinant protein  >12 publications with Itgb1 and Itgav
 Itga5 recombinant protein  >12 publications with Itgb1 and Itga5
 Itga3 recombinant protein  >9 publications with Itgb1 and Itga3
 Itga1 recombinant protein  >4 publications with Itgb1 and Itga1
 Tln1 recombinant protein  >3 publications with Itgb1 and Tln1
 Itga9 recombinant protein  >3 publications with Itgb1 and Itga9
 Itga7 recombinant protein  >3 publications with Itgb1 and Itga7
 Ilk recombinant protein  >2 publications with Itgb1 and Ilk
 Itga8 recombinant protein  >2 publications with Itgb1 and Itga8
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with Itgb1 recombinant proteinOrgans/Tissues associated with Itgb1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >13 publications with Itgb1 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >12 publications with Itgb1 and Neoplasm Invasiveness
 Inflammation Antibodies  >9 publications with Itgb1 and Inflammation
 Nervous System Diseases Antibodies  >9 publications with Itgb1 and Nervous System Diseases
 Fibrosis Antibodies  >7 publications with Itgb1 and Fibrosis
 Breast Neoplasms Antibodies  >7 publications with Itgb1 and Breast Neoplasms
 Kidney Diseases Antibodies  >5 publications with Itgb1 and Kidney Diseases
 Lung Neoplasms Antibodies  >5 publications with Itgb1 and Lung Neoplasms
 Brain Diseases Antibodies  >5 publications with Itgb1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >5 publications with Itgb1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with Itgb1 and Brain
 Embryonic Tissue Antibodies  >13 publications with Itgb1 and Embryonic Tissue
 Lung Antibodies  >12 publications with Itgb1 and Lung
 Kidney Antibodies  >10 publications with Itgb1 and Kidney
 Muscle Antibodies  >10 publications with Itgb1 and Muscle
 Prostate Antibodies  >8 publications with Itgb1 and Prostate
 Liver Antibodies  >7 publications with Itgb1 and Liver
 Placenta Antibodies  >6 publications with Itgb1 and Placenta
 Connective Tissue Antibodies  >6 publications with Itgb1 and Connective Tissue
 Eye Antibodies  >3 publications with Itgb1 and Eye
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