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ITGB3 recombinant protein :: Integrin beta-3 (ITGB3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953893 ITGB3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,120 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,275 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,515 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,530 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,570 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,620 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,670 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,780 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,300 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,315 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,375 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,690 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,030 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin beta-3 (ITGB3), Recombinant Protein

 Also Known As   

Recombinant Human Integrin beta-3 (ITGB3), partial

 Product Gene Name   

ITGB3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    27-718aa, Extracellular domain
 Sequence    GPNICTTRGV SSCQQCLAVS PMCAWCSDEA LPLGSPRCDL KENLLKDNCA PESIEFPVSE ARVLEDRPLS DKGSGDSSQV TQVSPQRIAL RLRPDDSKNF SIQVRQVEDY PVDIYYLMDL SYSMKDDLWS IQNLGTKLAT QMRKLTSNLR IGFGAFVDKP VSPYMYISPP EALENPCYDM KTTCLPMFGY KHVLTLTDQV TRFNEEVKKQ SVSRNRDAPE GGFDAIMQAT VCDEKIGWRN DASHLLVFTT DAKTHIALDG RLAGIVQPND GQCHVGSDNH YSASTTMDYP SLGLMTEKLS QKNINLIFAV TENVVNLYQN YSELIPGTTV GVLSMDSSNV LQLIVDAYGK IRSKVELEVR DLPEELSLSF NATCLNNEVI PGLKSCMGLK IGDTVSFSIE AKVRGCPQEK EKSFTIKPVG FKDSLIVQVT FDCDCACQAQ AEPNSHRCNN GNGTFECGVC RCGPGWLGSQ CECSEEDYRP SQQDECSPRE GQPVCSQRGE CLCGQCVCHS SDFGKITGKY CECDDFSCVR YKGEMCSGHG QCSCGDCLCD SDWTGYYCNC TTRTDTCMSS NGLLCSGRGK CECGSCVCIQ PGSYGDTCEK CPTCPDACTF KKECVECKKF DRGALHDENT CNRYCRDEIE SVKELKDTGK DAVNCTYKNE DDCVVRFQYY EDSSGKSILY VVEEPECPKG PD
 OMIM    173470
 3D Structure    ModBase 3D Structure for P05106
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ITGB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ITGB3 recombinant protein

   The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
NCBI/Uniprot data below describe general gene information for ITGB3. It may not necessarily be applicable to this product.
 NCBI GI #    47078292
 NCBI GeneID    3690
 NCBI Accession #    NP_000203.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000212.2 [Other Products]
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 UniProt Primary Accession #    P05106 [Other Products]
 UniProt Secondary Accession #    O15495; Q12806; Q13413; Q14648; Q16499; A0PJW2; D3DXJ8 [Other Products]
 UniProt Related Accession #    P05106 [Other Products]
 Molecular Weight    86,694 Da
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 NCBI Official Full Name    integrin beta-3
 NCBI Official Synonym Full Names    integrin subunit beta 3
 NCBI Official Symbol    ITGB3 [Similar Products]
 NCBI Official Synonym Symbols   
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
[Similar Products]
 NCBI Protein Information    integrin beta-3
 UniProt Protein Name    Integrin beta-3
 UniProt Synonym Protein Names   
Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
 Protein Family    Integrin
 UniProt Gene Name    ITGB3 [Similar Products]
 UniProt Synonym Gene Names    GP3A; GPIIIa [Similar Products]
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 NCBI Summary for ITGB3    The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGB3    Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887).
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 Research Articles on ITGB3    1. more pronounced level of platelet activation was found in polymorphism carriers. In conclusion, the carriage of PlA2 allele modulates the activation state, morphology, and membrane elasticity of platelets.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ITGB3 recombinant proteinPathways associated with ITGB3 recombinant protein
 Reference Product  PubMed Publications
 ITGA2B recombinant protein  >46 publications with ITGB3 and ITGA2B
 ITGAV recombinant protein  >13 publications with ITGB3 and ITGAV
 ITGA5 recombinant protein  >6 publications with ITGB3 and ITGA5
 PECAM1 recombinant protein  >4 publications with ITGB3 and PECAM1
 THBS1 recombinant protein  >3 publications with ITGB3 and THBS1
 SRC recombinant protein  >3 publications with ITGB3 and SRC
 PTK2 recombinant protein  >3 publications with ITGB3 and PTK2
 FN1 recombinant protein  >2 publications with ITGB3 and FN1
 FGG recombinant protein  >2 publications with ITGB3 and FGG
 FGA recombinant protein  >2 publications with ITGB3 and FGA
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with ITGB3 recombinant proteinOrgans/Tissues associated with ITGB3 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >52 publications with ITGB3 and Cardiovascular Diseases
 Neoplasms Antibodies  >38 publications with ITGB3 and Neoplasms
 Thrombocytopenia Antibodies  >25 publications with ITGB3 and Thrombocytopenia
 Thrombasthenia Antibodies  >25 publications with ITGB3 and Thrombasthenia
 Thrombosis Antibodies  >18 publications with ITGB3 and Thrombosis
 Myocardial Infarction Antibodies  >16 publications with ITGB3 and Myocardial Infarction
 Breast Neoplasms Antibodies  >12 publications with ITGB3 and Breast Neoplasms
 Stroke Antibodies  >10 publications with ITGB3 and Stroke
 Child Development Disorders, Pervasive Antibodies  >9 publications with ITGB3 and Child Development Disorders, Pervasive
 Autistic Disorder Antibodies  >9 publications with ITGB3 and Autistic Disorder
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >122 publications with ITGB3 and Blood
 Vascular Antibodies  >25 publications with ITGB3 and Vascular
 Bone Antibodies  >15 publications with ITGB3 and Bone
 Uterus Antibodies  >8 publications with ITGB3 and Uterus
 Placenta Antibodies  >8 publications with ITGB3 and Placenta
 Lung Antibodies  >6 publications with ITGB3 and Lung
 Kidney Antibodies  >6 publications with ITGB3 and Kidney
 Lymph Node Antibodies  >5 publications with ITGB3 and Lymph Node
 Muscle Antibodies  >4 publications with ITGB3 and Muscle
 Embryonic Tissue Antibodies  >4 publications with ITGB3 and Embryonic Tissue
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