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Itgb4 recombinant protein :: Integrin beta-4 (Itgb4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1359013 Itgb4 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,500 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,500 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,730 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,500 +3 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,500 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,960 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,960 +3 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,960 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $4,980 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin beta-4 (Itgb4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Integrin beta-4 (Itgb4), partial

 Product Gene Name   

Itgb4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Itgb4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1359013 COA    COA PDF
 Sequence Positions    28-713
 Sequence    NRC KKAQVKSCTE CIRVDKSCAY CTDELFKERR CNTQADVLAA GCRGESVLVM ESSLEITENI QIDTSLHRSQ VSPQGLQVRL RPGEERNFVF KVFEPLESPV DLYILMDFSN SMSDDLDNLK QMGQNLAKIL RQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP FSFKNVISLT ENVEEFWDKL QGERISGNLD APEGGFDAIL QTAVCTRDIG WRADSTHLLV FSTESAFHYE ADGANVLAGI MNRNDEKCHL DATGAYTQYK TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHKYF PVSSLGVLQE DSSNIVELLE EAFYRIRSNL DIRALDSPRG LRTEVTSDTL QKTETGSFHI KRGEVGTYNV HLRAVEDIDG THVCQLAKED QRGNIHLKPS FSDGLRMDAS VICDMCACEL QKEVQSARCH YRGDFMCGHC VCNEGWSGKT CNCSTGSLSD TQPCLREGED KPCSGHGECQ CGRCVCYGEG RYEGHFCEYD NFQCPRTSGF LCNDRGRCSM GECVCEPGWT GRSCDCPLSN ATCIDSNGGI CNGLGFCECG RCHCNQRSSL YTDTTCEINY SAIRLGLCED LRSCVQCQAW GTGEKKGRTC EECNFKVKMV DELKKAEEVV EYCSFRDEDD DCTYSYTVEG DGSPGPNSTV LVHKKKDCLP APS
 3D Structure    ModBase 3D Structure for Q64632
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Itgb4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Itgb4 recombinant protein

   Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Itgb4. It may not necessarily be applicable to this product.
 NCBI GI #    6981108
 NCBI GeneID    25724
 NCBI Accession #    NP_037312.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013180.1 [Other Products]
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 UniProt Primary Accession #    Q64632 [Other Products]
 UniProt Related Accession #    Q64632 [Other Products]
 Molecular Weight    200,589 Da
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 NCBI Official Full Name    integrin beta-4
 NCBI Official Synonym Full Names    integrin subunit beta 4
 NCBI Official Symbol    Itgb4 [Similar Products]
 NCBI Protein Information    integrin beta-4
 UniProt Protein Name    Integrin beta-4
 UniProt Synonym Protein Names   
GP150; CD_antigen: CD104
 Protein Family    Integrin
 UniProt Gene Name    Itgb4 [Similar Products]
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 NCBI Summary for Itgb4    beta subunit of integrin alpha6/beta4 which is a cell surface receptor for laminin; involved in hemidesmosome formation [RGD, Feb 2006]
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 UniProt Comments for Itgb4    Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling ().
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 Research Articles on Itgb4    1. this study suggests that downregulation of integrin beta4 is important for the development ozone stress-induced airway hyperresponsiveness, presumably because it causes increased oxidative damage and epithelial apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Itgb4 recombinant proteinPathways associated with Itgb4 recombinant protein
 Reference Product  PubMed Publications
 Itga6 recombinant protein  >19 publications with Itgb4 and Itga6
 Cd151 recombinant protein  >14 publications with Itgb4 and Cd151
 Lamc2 recombinant protein  >11 publications with Itgb4 and Lamc2
 Plec1 recombinant protein  >7 publications with Itgb4 and Plec1
 Prkca recombinant protein  >3 publications with Itgb4 and Prkca
 Lamb3 recombinant protein  >3 publications with Itgb4 and Lamb3
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with Itgb4 recombinant proteinOrgans/Tissues associated with Itgb4 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >247 publications with Itgb4 and Neoplasms
 Carcinoma Antibodies  >161 publications with Itgb4 and Carcinoma
 Gastrointestinal Diseases Antibodies  >55 publications with Itgb4 and Gastrointestinal Diseases
 Adenocarcinoma Antibodies  >53 publications with Itgb4 and Adenocarcinoma
 Breast Neoplasms Antibodies  >53 publications with Itgb4 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >44 publications with Itgb4 and Neoplasm Metastasis
 Colorectal Neoplasms Antibodies  >38 publications with Itgb4 and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >31 publications with Itgb4 and Colonic Neoplasms
 Carcinoma, Squamous Cell Antibodies  >28 publications with Itgb4 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >27 publications with Itgb4 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >46 publications with Itgb4 and Lung
 Prostate Antibodies  >23 publications with Itgb4 and Prostate
 Brain Antibodies  >20 publications with Itgb4 and Brain
 Connective Tissue Antibodies  >13 publications with Itgb4 and Connective Tissue
 Pancreas Antibodies  >6 publications with Itgb4 and Pancreas
 Dorsal Root Ganglion Antibodies  >5 publications with Itgb4 and Dorsal Root Ganglion
 Inner Ear Antibodies  >4 publications with Itgb4 and Inner Ear
 Uncharacterized Tissue Antibodies  >2 publications with Itgb4 and Uncharacterized Tissue
 Adipose Tissue Antibodies  >1 publications with Itgb4 and Adipose Tissue
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