AAQ14901.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,825 Da
NCBI Official Full Name
intercellular adhesion molecule 1
NCBI Official Synonym Full Names
intercellular adhesion molecule 1
NCBI Protein Information
intercellular adhesion molecule 1
UniProt Protein Name
Intercellular adhesion molecule 1
UniProt Synonym Protein Names
Major group rhinovirus receptor; CD_antigen: CD54
UniProt Synonym Gene Names
UniProt Entry Name
ICAM1_HUMAN
NCBI Summary for ICAM-1
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for ICAM-1
ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: cell surface; extracellular space; focal adhesion; integral to plasma membrane; membrane; plasma membrane
Molecular Function: integrin binding; protein binding; receptor activity; transmembrane receptor activity
Biological Process: adhesion to host; cell adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte migration; membrane to membrane docking; positive regulation of cellular extravasation; regulation of immune response; regulation of leukocyte mediated cytotoxicity; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; virion attachment, binding of host cell surface receptor
Disease: Malaria, Susceptibility To
Research Articles on ICAM-1
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Products associated with ICAM-1 western blot control
Pathways associated with ICAM-1 western blot control
Diseases associated with ICAM-1 western blot control
Organs/Tissues associated with ICAM-1 western blot control
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