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ICAM1 recombinant protein :: Intercellular Adhesion Molecule-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142938 ICAM1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,625 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Intercellular Adhesion Molecule-1 (ICAM1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Intercellular Adhesion Molecule-1

 Product Synonym Names    ICAM-1 Human; Intercellular Adhesion Molecule-1 Human Recombinant; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD54 antigen; ICAM1; BB2; CD54; P3.58
 Product Gene Name   

ICAM1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147840
 3D Structure    ModBase 3D Structure for P05362
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    ICAM-1 is supplied (0.2mg/ml) in PBS, 50% Glycerol, 2mM Imidazole.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 1-2 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of ICAM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ICAM1 recombinant protein

   Description: ICAM-1 Human Recombinant is expressed in E Coli containing 455 amino acids 28-483 fused to an amino terminal hexahistidine tag.The ICAM-1 is purified by proprietary chromatographic techniques.

Introduction: ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction, cell signaling and lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18, or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes and endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFA) and is expressed by the vascular endothelium, macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.ICAM-1 is implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be notably elevated in patients with SAH. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions.
 Product Categories/Family for ICAM1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
 Applications Tested/Suitable for ICAM1 recombinant protein   

Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

 Application Notes for ICAM1 recombinant protein    ICAM-I can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments. The biological activity of this product has not yet been tested.
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NCBI/Uniprot data below describe general gene information for ICAM1. It may not necessarily be applicable to this product.
 NCBI GI #    167466198
 NCBI GeneID    3383
 NCBI Accession #    NP_000192.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000201.2 [Other Products]
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 UniProt Primary Accession #    P05362 [Other Products]
 UniProt Secondary Accession #    Q5NKV7; Q96B50; B2R6M3 [Other Products]
 UniProt Related Accession #    P05362 [Other Products]
 Molecular Weight    57,825 Da
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 NCBI Official Full Name    intercellular adhesion molecule 1
 NCBI Official Synonym Full Names    intercellular adhesion molecule 1
 NCBI Official Symbol    ICAM1 [Similar Products]
 NCBI Official Synonym Symbols   
BB2; CD54; P3.58
[Similar Products]
 NCBI Protein Information    intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor
 UniProt Protein Name    Intercellular adhesion molecule 1
 UniProt Synonym Protein Names   
Major group rhinovirus receptor; CD_antigen: CD54
 Protein Family    Intercellular adhesion molecule
 UniProt Gene Name    ICAM1 [Similar Products]
 UniProt Synonym Gene Names    ICAM-1 [Similar Products]
 UniProt Entry Name    ICAM1_HUMAN
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 NCBI Summary for ICAM1    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ICAM1    ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane

Molecular Function: viral receptor activity; integrin binding; protein binding; transmembrane receptor activity; receptor activity

Biological Process: extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; regulation of cell adhesion; response to drug; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration

Disease: Malaria, Susceptibility To
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 Research Articles on ICAM1    1. ICAM1 is likely to be involved in the development of childhood asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ICAM1 recombinant proteinPathways associated with ICAM1 recombinant protein
 Reference Product  PubMed Publications
 ITGB2 recombinant protein  >880 publications with ICAM1 and ITGB2
 ITGAL recombinant protein  >474 publications with ICAM1 and ITGAL
 ITGAM recombinant protein  >440 publications with ICAM1 and ITGAM
 CD44 recombinant protein  >371 publications with ICAM1 and CD44
 IL6 recombinant protein  >153 publications with ICAM1 and IL6
 ITGAX recombinant protein  >139 publications with ICAM1 and ITGAX
 SELE recombinant protein  >87 publications with ICAM1 and SELE
 HLA-B recombinant protein  >29 publications with ICAM1 and HLA-B
 DIF recombinant protein  >3 publications with ICAM1 and DIF
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with ICAM1 recombinant proteinOrgans/Tissues associated with ICAM1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5647 publications with ICAM1 and Inflammation
 Necrosis Antibodies  >4802 publications with ICAM1 and Necrosis
 Cardiovascular Diseases Antibodies  >3660 publications with ICAM1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1471 publications with ICAM1 and Atherosclerosis
 Reperfusion Injury Antibodies  >885 publications with ICAM1 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >797 publications with ICAM1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >760 publications with ICAM1 and Kidney Diseases
 Hypertension Antibodies  >527 publications with ICAM1 and Hypertension
 Asthma Antibodies  >503 publications with ICAM1 and Asthma
 Stroke Antibodies  >388 publications with ICAM1 and Stroke
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11802 publications with ICAM1 and Blood
 Vascular Antibodies  >8832 publications with ICAM1 and Vascular
 Lung Antibodies  >1777 publications with ICAM1 and Lung
 Heart Antibodies  >1290 publications with ICAM1 and Heart
 Skin Antibodies  >1198 publications with ICAM1 and Skin
 Liver Antibodies  >1183 publications with ICAM1 and Liver
 Kidney Antibodies  >1179 publications with ICAM1 and Kidney
 Brain Antibodies  >1177 publications with ICAM1 and Brain
 Muscle Antibodies  >1050 publications with ICAM1 and Muscle
 Embryonic Tissue Antibodies  >774 publications with ICAM1 and Embryonic Tissue
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