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IFNg recombinant protein :: Interferon Gamma (IFNg) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS343051 IFNg recombinant protein
Unit / Price
0.01 mg  /  $205 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon Gamma (IFNg), Recombinant Protein

 Also Known As   

Interferon Gamma (IFNg) (Western Blot Control)

 Product Synonym Names    Immune Interferon, type II interferon, T cell interferon, MAF, IFNG, IFG, IFI, IFN-gamma.
 Product Gene Name   

IFNg recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147570
 3D Structure    ModBase 3D Structure for P01579
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 Purity/Purification    >= 95% (SDS PAGE)
 Form/Format    Liquid
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of IFNg recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IFNg recombinant protein

   IFN gamma is a potent multifunctional cytokine primarily produced by T cells and natural killer cells. IFN gamma exerts a variety of antiproliferative, immunoregulatory and pro-inflammatory biological activities in response to binding at specific cell surface receptors. Recombinant IFN gamma comprises a 143 amino acid fragment (24-166) corresponding to the mature soluble IFN gamma chain protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
 Product Categories/Family for IFNg recombinant protein    Recombinant Proteins; Interferon Gamma
NCBI/Uniprot data below describe general gene information for IFNg. It may not necessarily be applicable to this product.
 NCBI GI #    184639
 NCBI GeneID    3458
 NCBI Accession #    AAB59534.1 [Other Products]
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 UniProt Primary Accession #    P01579 [Other Products]
 UniProt Secondary Accession #    Q53ZV4; B5BU88 [Other Products]
 UniProt Related Accession #    P01579 [Other Products]
 Molecular Weight    19,348 Da
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 NCBI Official Full Name    interferon-gamma
 NCBI Official Synonym Full Names    interferon gamma
 NCBI Official Symbol    IFNG [Similar Products]
 NCBI Official Synonym Symbols   
IFG; IFI
[Similar Products]
 NCBI Protein Information    interferon gamma
 UniProt Protein Name    Interferon gamma
 UniProt Synonym Protein Names   
Immune interferon
 Protein Family    Interferon
 UniProt Gene Name    IFNG [Similar Products]
 UniProt Synonym Gene Names    IFN-gamma [Similar Products]
 UniProt Entry Name    IFNG_HUMAN
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 NCBI Summary for IFNg    This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
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 UniProt Comments for IFNg    IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.

Protein type: Membrane protein, integral; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity

Biological Process: adaptive immune response; apoptosis; cell cycle arrest; cell motility; cell surface receptor linked signal transduction; humoral immune response; negative regulation of epithelial cell differentiation; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response; positive regulation of cell proliferation; positive regulation of interleukin-12 production; positive regulation of interleukin-23 production; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of Stat1 protein; protein import into nucleus, translocation; regulation of insulin secretion; response to virus

Disease: Aplastic Anemia; Hepatitis C Virus, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2
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Product References and Citations for IFNg recombinant protein

   Schreiber, R.D. & Farrar, M.A. (1993) Gastroenterol. J. 28(4): 88- 94.
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 Research Articles on IFNg    1. firstly the genetic variant of IFNgamma (rs1861494) is involved with the regulation of amygdala reactivity to emotional stimuli and secondly, that this genetic variant moderates effects of early life stress on emotion processing.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFNg recombinant proteinPathways associated with IFNg recombinant protein
 Reference Product  PubMed Publications
 TNF recombinant protein  >235 publications with IFNg and TNF
 IL2 recombinant protein  >86 publications with IFNg and IL2
 TBX21 recombinant protein  >72 publications with IFNg and TBX21
 TGFB1 recombinant protein  >61 publications with IFNg and TGFB1
 STAT1 recombinant protein  >58 publications with IFNg and STAT1
 IFNGR1 recombinant protein  >38 publications with IFNg and IFNGR1
 IRF1 recombinant protein  >20 publications with IFNg and IRF1
 IFNGR2 recombinant protein  >19 publications with IFNg and IFNGR2
 IL18R1 recombinant protein  >3 publications with IFNg and IL18R1
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
Diseases associated with IFNg recombinant proteinOrgans/Tissues associated with IFNg recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >199 publications with IFNg and Necrosis
 Autoimmune Diseases Antibodies  >113 publications with IFNg and Autoimmune Diseases
 Respiratory Tract Diseases Antibodies  >100 publications with IFNg and Respiratory Tract Diseases
 Hepatitis Antibodies  >47 publications with IFNg and Hepatitis
 Lymphoproliferative Disorders Antibodies  >34 publications with IFNg and Lymphoproliferative Disorders
 HIV Infections Antibodies  >26 publications with IFNg and HIV Infections
 Colitis Antibodies  >25 publications with IFNg and Colitis
 Hepatitis C Antibodies  >22 publications with IFNg and Hepatitis C
 Diabetes Mellitus, Type 1 Antibodies  >20 publications with IFNg and Diabetes Mellitus, Type 1
 Arthritis, Rheumatoid Antibodies  >19 publications with IFNg and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >706 publications with IFNg and Blood
 Kidney Antibodies  >56 publications with IFNg and Kidney
 Lymph Node Antibodies  >31 publications with IFNg and Lymph Node
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