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IFNA2 recombinant protein :: Interferon alpha 2b Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650810 IFNA2 recombinant protein
Unit / Price
0.01 mg  /  $425 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon alpha 2b (IFNA2), Recombinant Protein

 Also Known As   

Interferon alpha 2b, Recombinant, Human (IFNa2b) (Human 293 Cells)

 Product Gene Name   

IFNA2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (21384254..21385396, complement). Location: 9p22
 OMIM    147562
 3D Structure    ModBase 3D Structure for P01563
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 Purity/Purification    Highly Purified
95% as determined by SDS-PAGE and HPLC. Endotoxin: 1EU/ug (LAL)
 Form/Format    Supplied as a lyophilized powder from 20mM Tris, pH 7.4, 150mM NaCl. Reconstitute with sterile PBS, 0.1% endotoxin-free recombinant HSA .
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 Activity    The specific activity was determined by the dose-dependent proliferation of WISH
(heteroploid human amnion cell line) in presence of VSV (vesicular stomatitis virus).
 Specific Activity    ~30pg/ml ED50
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS, 0.1% endotoxin-free recombinant HSA. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of IFNA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for IFNA2 recombinant protein    Growth Factors, Cytokines; Growth Factors-Interferon
NCBI/Uniprot data below describe general gene information for IFNA2. It may not necessarily be applicable to this product.
 NCBI GI #    11067751
 NCBI GeneID    3440
 NCBI Accession #    NP_000596.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000605.3 [Other Products]
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 UniProt Primary Accession #    P01563 [Other Products]
 UniProt Secondary Accession #    P01564; Q14606; Q96KI6 [Other Products]
 UniProt Related Accession #    P01563 [Other Products]
 Molecular Weight    ~15kD [Similar Products]
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 NCBI Official Full Name    interferon alpha-2
 NCBI Official Synonym Full Names    interferon, alpha 2
 NCBI Official Symbol    IFNA2 [Similar Products]
 NCBI Official Synonym Symbols   
IFNA; INFA2; IFNA2B; IFN-alphaA
[Similar Products]
 NCBI Protein Information    interferon alpha-2; leIF A; IFN-alpha-2; interferon alpha A; alpha-2a interferon; interferon alpha 2a; interferon alpha 2b
 UniProt Protein Name    Interferon alpha-2
 UniProt Synonym Protein Names   
Interferon alpha-A
 UniProt Gene Name    IFNA2 [Similar Products]
 UniProt Synonym Gene Names    IFN-alpha-2; LeIF A [Similar Products]
 UniProt Entry Name    IFNA2_HUMAN
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 NCBI Summary for IFNA2    This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
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 UniProt Comments for IFNA2    Function: Produced by macrophages, IFN-alpha have antiviral activities.

Subunit structure: Interacts with IFNAR2. Ref.16 Ref.17

Subcellular location: Secreted.

Polymorphism: Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c.

Pharmaceutical use: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity.

Sequence similarities: Belongs to the alpha/beta interferon family.
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 Research Articles on IFNA2    1. These studies identify IFNalpha derived from lymph nodes, rather than blood leukocytes, as a possible source of the IFN-I signature that contributes to immune activation in HIV-1 infection
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFNA2 recombinant proteinPathways associated with IFNA2 recombinant protein
 Reference Product  PubMed Publications
 IFNAR1 recombinant protein  >334 publications with IFNA2 and IFNAR1
 STAT2 recombinant protein  >272 publications with IFNA2 and STAT2
 IFNAR2 recombinant protein  >178 publications with IFNA2 and IFNAR2
 TYK2 recombinant protein  >153 publications with IFNA2 and TYK2
 IRF9 recombinant protein  >138 publications with IFNA2 and IRF9
 IRF1 recombinant protein  >116 publications with IFNA2 and IRF1
 IL2 recombinant protein  >70 publications with IFNA2 and IL2
 IRF2 recombinant protein  >43 publications with IFNA2 and IRF2
 IFNG recombinant protein  >16 publications with IFNA2 and IFNG
 IFNA5 recombinant protein  >4 publications with IFNA2 and IFNA5
 Products by Pathway  Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
Diseases associated with IFNA2 recombinant protein
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >2418 publications with IFNA2 and Skin Diseases
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >1388 publications with IFNA2 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Carcinoma, Renal Cell Antibodies  >1341 publications with IFNA2 and Carcinoma, Renal Cell
 Anemia Antibodies  >812 publications with IFNA2 and Anemia
 Viremia Antibodies  >777 publications with IFNA2 and Viremia
 Fever Antibodies  >746 publications with IFNA2 and Fever
 Lymphoma, Non-Hodgkin Antibodies  >690 publications with IFNA2 and Lymphoma, Non-Hodgkin
 Fatigue Antibodies  >606 publications with IFNA2 and Fatigue
 Mental Disorders Antibodies  >593 publications with IFNA2 and Mental Disorders
 Thrombocytopenia Antibodies  >584 publications with IFNA2 and Thrombocytopenia
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