NP_000865.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interferon alpha/beta receptor 2 isoform b
NCBI Official Synonym Full Names
interferon alpha and beta receptor subunit 2
NCBI Official Synonym Symbols
IFN-R; IFNABR; IFNARB; IFN-alpha-REC [Similar Products]
NCBI Protein Information
interferon alpha/beta receptor 2
UniProt Protein Name
Interferon alpha/beta receptor 2
UniProt Synonym Protein Names
Interferon alpha binding protein; Type I interferon receptor 2
UniProt Synonym Gene Names
IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2 [Similar Products]
UniProt Entry Name
INAR2_HUMAN
NCBI Summary for IFNAR2
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNAR2
IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: extracellular region; extracellular space; integral to plasma membrane; intracellular; plasma membrane
Molecular Function: interferon-alpha/beta binding; interferon-alpha/beta receptor activity; interleukin-20 binding; protein binding; protein kinase binding
Biological Process: cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; response to virus
Disease: Hepatitis B Virus, Susceptibility To
Product References and Citations for IFNAR2 recombinant protein
The human interferon alpha/beta receptor
characterization and molecular cloning.Novick D., Cohen B., Rubinstein M.Cell 77:391-400(1994)
Research Articles on IFNAR2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with IFNAR2 recombinant protein
Pathways associated with IFNAR2 recombinant protein
Diseases associated with IFNAR2 recombinant protein
Organs/Tissues associated with IFNAR2 recombinant protein
|