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PRKRA recombinant protein :: Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1422845 PRKRA recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $845 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $985 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,135 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,225 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,245 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,285 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,790 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,860 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,950 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,385 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA)

 Product Gene Name   

PRKRA recombinant protein

[Similar Products]
 Product Synonym Gene Name    PRKRA [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1422845 COA    COA PDF
 Sequence Positions    1-313aa, Full Length
 Sequence    MSQSRHRAAA PPMEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDPSKQ PKNQLNPIGS LQELAIHHGW RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA KRNAAEKFLA KFSNISPENH ISLTNMVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD YIQLLSEIAK EQGFNITYLD IEELSANGQY QCLAELSTSP ITVCHGSGIS CSSAQSDAAH NALQYLKIIA ERK
 3D Structure    ModBase 3D Structure for Q2HJ92
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 85% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Bos taurus (Bovine)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PRKRA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRKRA recombinant protein

   Activates EIF2AK2
PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1
EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53
TP53 association and sumoylation and phosphorylation of p53
TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2
PKR-dependent manner
 Product Categories/Family for PRKRA recombinant protein    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for PRKRA. It may not necessarily be applicable to this product.
 NCBI GI #    114052769
 NCBI GeneID    282875
 NCBI Accession #    NP_001039335.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001045870.1 [Other Products]
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 UniProt Primary Accession #    Q2HJ92 [Other Products]
 UniProt Related Accession #    Q2HJ92 [Other Products]
 Molecular Weight    39.4 kDa
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 NCBI Official Full Name    interferon-inducible double-stranded RNA-dependent protein kinase activator A
 NCBI Official Synonym Full Names    protein activator of interferon induced protein kinase EIF2AK2
 NCBI Official Symbol    PRKRA [Similar Products]
 NCBI Official Synonym Symbols   
PACT
[Similar Products]
 NCBI Protein Information    interferon-inducible double-stranded RNA-dependent protein kinase activator A
 UniProt Protein Name    Interferon-inducible double-stranded RNA-dependent protein kinase activator A
 UniProt Synonym Protein Names   
Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator
 Protein Family    Interferon-inducible double-stranded RNA-dependent protein kinase activator
 UniProt Gene Name    PRKRA [Similar Products]
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 UniProt Comments for PRKRA    Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner ().
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 Research Articles on PRKRA    1. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT, PRKRA) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRKRA recombinant proteinPathways associated with PRKRA recombinant protein
 Reference Product  PubMed Publications
 DICER1 recombinant protein  >8 publications with PRKRA and DICER1
 EIF2C2 recombinant protein  >6 publications with PRKRA and EIF2C2
 TARBP2 recombinant protein  >4 publications with PRKRA and TARBP2
 ATP7B recombinant protein  >1 publications with PRKRA and ATP7B
 PPP1CA recombinant protein  >1 publications with PRKRA and PPP1CA
 RNASEN recombinant protein  >1 publications with PRKRA and RNASEN
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 MicroRNA (miRNA) Biogenesis Pathway antibodies  MicroRNA (miRNA) Biogenesis Pathway Diagram
 Regulatory RNA Pathways antibodies  Regulatory RNA Pathways Diagram
 Small Interfering RNA (siRNA) Biogenesis Pathway antibodies  Small Interfering RNA (siRNA) Biogenesis Pathway Diagram
Diseases associated with PRKRA recombinant proteinOrgans/Tissues associated with PRKRA recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with PRKRA and Nervous System Diseases
 Dystonia Antibodies  >11 publications with PRKRA and Dystonia
 Brain Diseases Antibodies  >8 publications with PRKRA and Brain Diseases
 Necrosis Antibodies  >1 publications with PRKRA and Necrosis
 Seizures Antibodies  >1 publications with PRKRA and Seizures
 Precancerous Conditions Antibodies  >1 publications with PRKRA and Precancerous Conditions
 Hyperplasia Antibodies  >1 publications with PRKRA and Hyperplasia
 Disease Models, Animal Antibodies  >1 publications with PRKRA and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with PRKRA and Brain
 Muscle Antibodies  >2 publications with PRKRA and Muscle
 Intestine Antibodies  >1 publications with PRKRA and Intestine
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