|
| Product Name
|
|
Interleukin 1 Family (IL1F10), Recombinant Protein ★Popular Item★
|
| Also Known As
|
|
Recombinant Human Interleukin 1 Family, Member 10
|
| Product Synonym Names
|
|
IL1F10 Human; Interleukin 1 Family, Member 10 Human Recombinant; Interleukin-1 family member 10; IL-1F10; FIL1 theta; Interleukin-1 HY2; IL-1HY2; Interleukin-1 theta; IL-1 theta; IL1F10; FIL1T; IL1HY2; FKSG75; MGC119831; MGC119832; MGC119833; FIL1-theta
|
| Product Gene Name
|
|
|
[Similar Products]
|
| Research Use Only
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
 TOP
|
|
| Sequence
|
|
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Cys-Se r-Leu-Pro
|
| OMIM
|
|
615296
|
| 3D Structure
|
|
ModBase 3D Structure for Q8WWZ1
|
|
| Host
|
|
E Coli
|
|
|
| Purity/Purification
|
|
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
|
| Form/Format
|
|
IL1F10 was lyophilized after extensive dialysis against 20mM Phosphate buffer, pH7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
|
|
|
| Solubility
|
|
It is recommended to quick spin followed by reconstitution of IL1F10 in PBS to a concentration no less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
|
| Biological Activity
|
|
As measured by its binding ability in a functional ELISA, immobilized IL1F10 at 1 ug/ml (100 ul/well) can bind rHuIL-1 Rrp2/Fc Chimera with a linear range of 0.15- 5 ug/ml.
|
|
|
| Preparation and Storage
|
|
Lyophilized IL1F10 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL1F10 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
|
| Other Notes
|
|
Small volumes of IL1F10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
|
|
TOP
|
|
|
|
|
Description: IL1F10 Human Recombinant produced in E Coli is a single, non-glycosylated, Polypeptide chain containing 152 amino acids and having a molecular mass of 17kDa.The IL1F10 is purified by proprietary chromatographic techniques.
Introduction: Human interleukin family 1, member 10 (IL1F10) belongs to the interleukin 1 cytokine family. IL1F10 is expressed in the fetal skin, spleen and tonsil, generally in the basal epithelia of skin and in proliferating B-cells of the tonsil. IL1F10 binds soluble IL1 receptor type 1 and may be implicated in the regulation of adapted and innate immune responses.
|
| Product Categories/Family for IL1F10 recombinant protein
|
|
CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
|
|
| NCBI/Uniprot data below describe general gene information for IL1F10. It may not necessarily be applicable to this product. |
| NCBI GI #
|
|
27894304
|
| NCBI GeneID
|
|
84639
|
| NCBI Accession #
|
|
NP_115945.4
|
[Other Products]
|
| NCBI GenBank Nucleotide #
|
|
NM_032556.5
|
[Other Products]
|
|
|
| UniProt Primary Accession #
|
|
Q8WWZ1
|
[Other Products]
|
| UniProt Secondary Accession #
|
|
Q53SR9; Q56AT8; Q7RTZ5; Q969H5; Q9BYX1
|
[Other Products]
|
| UniProt Related Accession #
|
|
Q8WWZ1
|
[Other Products]
|
| Molecular Weight
|
|
16,701 Da
|
|
TOP
|
| NCBI Official Full Name
|
|
interleukin-1 family member 10
|
| NCBI Official Synonym Full Names
|
|
interleukin 1 family, member 10 (theta)
|
| NCBI Official Symbol
|
|
IL1F10
|
[Similar Products]
|
| NCBI Official Synonym Symbols
|
|
IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
|
[Similar Products]
|
| NCBI Protein Information
|
|
interleukin-1 family member 10; FIL1 theta; IL-1 theta; IL-1F10 (canonical form IL-1F10a); family of interleukin 1-theta; interleukin-1 HY2; interleukin-1 receptor antagonist FKSG75; interleukin-1 receptor antagonist-like FIL1 theta; interleukin-38
|
| UniProt Protein Name
|
|
Interleukin-1 family member 10
|
| UniProt Synonym Protein Names
|
|
Family of interleukin 1-theta; FIL1 theta; Interleukin-1 HY2; IL-1HY2; Interleukin-1 theta; IL-1 theta; Interleukin-38; IL-38
|
| Protein Family
|
|
Interleukin-1 family
|
| UniProt Gene Name
|
|
IL1F10
|
[Similar Products]
|
| UniProt Synonym Gene Names
|
|
FIL1T; IL1HY2; IL38; IL-1F10; FIL1 theta; IL-1HY2; IL-1 theta; IL-38
|
[Similar Products]
|
| UniProt Entry Name
|
|
IL1FA_HUMAN
|
|
|
| NCBI Summary for IL1F10
|
|
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
|
|
|
| UniProt Comments for IL1F10
|
|
IL1F10: Binds soluble IL-1 receptor type 1. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q13
Cellular Component: extracellular space
Molecular Function: interleukin-1 receptor binding; cytokine activity
Biological Process: cytokine and chemokine mediated signaling pathway
|
|
TOP
|
|
| Research Articles on IL1F10
|
|
1. rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance.
|
|
TOP
|
| Precautions
|
|
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
|
| Disclaimer
|
|
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
|
|
TOP
|
|
| Products associated with IL1F10 recombinant protein | Diseases associated with IL1F10 recombinant protein |
|
|
|
| Organs/Tissues associated with IL1F10 recombinant protein |
|
|
|
|
|
TOP
|
Recombinant Protein 
