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IL 1RA recombinant protein :: Interleukin-1 Receptor Antagonist Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142080 IL 1RA recombinant protein
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,030 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-1 Receptor Antagonist (IL 1RA), Recombinant Protein

 Also Known As   

Recombinant Human Interleukin-1 Receptor Antagonist

 Product Synonym Names    IL 1RA Human; Interleukin-1 Receptor Antagonist Human Recombinant; IRAP; IL1F3; IL1RA; IL-1ra3; ICIL-1RA; IL1RN; IL1 inhibitor; IL-1ra; MGC10430
 Product Gene Name   

IL 1RA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Pr o-Ser-Gly
 OMIM    147679
 3D Structure    ModBase 3D Structure for P18510
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized protein with no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Interleukin-1 ra in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.89 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-1 ra as a Reference Standard.
 Biological Activity    The ED50 as determined by the dose-dependant inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ng/ml corresponding to a Specific Activity of 2,000,000IU/mg.
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 Preparation and Storage    Lyophilized Interleukin 1ra although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL-1ra should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of IL 1RA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL 1RA recombinant protein

   Description: IL1ra Human Recombinant produced in E Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton. The IL1ra is purified by proprietary chromatographic techniques.

Introduction: Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
 Product Categories/Family for IL 1RA recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for IL 1RA. It may not necessarily be applicable to this product.
 NCBI GI #    10835147
 NCBI GeneID    3557
 NCBI Accession #    NP_000568.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000577.4 [Other Products]
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 UniProt Primary Accession #    P18510 [Other Products]
 UniProt Secondary Accession #    Q14628; Q53SC2; Q7RTZ4; Q96GD6; Q9UPC0; A8K4G1 [Other Products]
 UniProt Related Accession #    P18510 [Other Products]
 Molecular Weight    16,142 Da
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 NCBI Official Full Name    interleukin-1 receptor antagonist protein isoform 3
 NCBI Official Synonym Full Names    interleukin 1 receptor antagonist
 NCBI Official Symbol    IL1RN [Similar Products]
 NCBI Official Synonym Symbols   
DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist
 UniProt Protein Name    Interleukin-1 receptor antagonist protein
 UniProt Synonym Protein Names   
ICIL-1RA; IL1 inhibitor; INN: Anakinra
 Protein Family    Interleukin-1 receptor antagonist protein
 UniProt Gene Name    IL1RN [Similar Products]
 UniProt Synonym Gene Names    IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP [Similar Products]
 UniProt Entry Name    IL1RA_HUMAN
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 NCBI Summary for IL 1RA    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL 1RA    IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Vesicle; Secreted

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular

Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity

Biological Process: response to drug; positive regulation of JNK activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of glutamate secretion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; fever; sensory perception of pain; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; response to activity; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis

Disease: Gastric Cancer, Hereditary Diffuse; Microvascular Complications Of Diabetes, Susceptibility To, 4; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
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 Research Articles on IL 1RA    1. SFAs, but not unsaturated fatty acids (UFAs), increased interleukin (IL)-1beta secretion and decreased IL-1 receptor antagonist (IL-1Ra) secretion, resulting in an increase in the IL-1beta/IL-1Ra secretion ratio
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL 1RA recombinant proteinPathways associated with IL 1RA recombinant protein
 Reference Product  PubMed Publications
 IL1A recombinant protein  >93 publications with IL 1RA and IL1A
 IL8 recombinant protein  >25 publications with IL 1RA and IL8
 IL4 recombinant protein  >24 publications with IL 1RA and IL4
 IL1R1 recombinant protein  >18 publications with IL 1RA and IL1R1
 IL1R2 recombinant protein  >6 publications with IL 1RA and IL1R2
 MMP3 recombinant protein  >5 publications with IL 1RA and MMP3
 IL1RL2 recombinant protein  >2 publications with IL 1RA and IL1RL2
 SELE recombinant protein  >1 publications with IL 1RA and SELE
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
Diseases associated with IL 1RA recombinant proteinOrgans/Tissues associated with IL 1RA recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >778 publications with IL 1RA and Necrosis
 Inflammation Antibodies  >697 publications with IL 1RA and Inflammation
 Arthritis, Rheumatoid Antibodies  >302 publications with IL 1RA and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >190 publications with IL 1RA and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >165 publications with IL 1RA and Disease Models, Animal
 Skin Diseases Antibodies  >126 publications with IL 1RA and Skin Diseases
 Lung Diseases Antibodies  >111 publications with IL 1RA and Lung Diseases
 Pain Antibodies  >82 publications with IL 1RA and Pain
 Kidney Diseases Antibodies  >80 publications with IL 1RA and Kidney Diseases
 Heart Diseases Antibodies  >76 publications with IL 1RA and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1072 publications with IL 1RA and Blood
 Brain Antibodies  >179 publications with IL 1RA and Brain
 Skin Antibodies  >127 publications with IL 1RA and Skin
 Liver Antibodies  >110 publications with IL 1RA and Liver
 Lung Antibodies  >110 publications with IL 1RA and Lung
 Heart Antibodies  >82 publications with IL 1RA and Heart
 Stomach Antibodies  >51 publications with IL 1RA and Stomach
 Spleen Antibodies  >43 publications with IL 1RA and Spleen
 Intestine Antibodies  >40 publications with IL 1RA and Intestine
 Eye Antibodies  >38 publications with IL 1RA and Eye
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