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Il10 recombinant protein :: Interleukin-10 protein (Il10) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969453
SDS-PAGE
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
0.25 mg  /  $1,230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-10 protein (Il10), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Interleukin-10 protein (Il10) (Active)

 Product Synonym Names    IL-10; CSIF
 Product Gene Name   

Il10 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Il-10 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    19-178aa, Full Length of Mature Protein
 Sequence    SRGQYSREDN NCTHFPVGQS HMLLELRTAF SQVKTFFQTK DQLDNILLTD SLMQDFKGYL GCQALSEMIQ FYLVEVMPQA EKHGPEIKEH LNSLGEKLKT LRMRLRRCHR FLPCENKSKA VEQVKSDFNK LQDQGVYKAM NEFDIFINCI EAYMMIKMKS
 3D Structure    ModBase 3D Structure for P18893
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine MC/9-2 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 106 IU/mg.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Il10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Il10 recombinant protein

   Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
 Product Categories/Family for Il10 recombinant protein    Biological Active Protein; Immunology; Interleukin
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 SDS-PAGE of Il10 recombinant protein    Il10 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Il10. It may not necessarily be applicable to this product.
 NCBI GI #    6754318
 NCBI GeneID    16153
 NCBI Accession #    NP_034678.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010548.2 [Other Products]
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 UniProt Primary Accession #    P18893 [Other Products]
 UniProt Secondary Accession #    Q0VBJ1 [Other Products]
 UniProt Related Accession #    P18893 [Other Products]
 Molecular Weight    18.7 kDa
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 NCBI Official Full Name    interleukin-10
 NCBI Official Synonym Full Names    interleukin 10
 NCBI Official Symbol    Il10 [Similar Products]
 NCBI Official Synonym Symbols   
CSIF; Il-10
[Similar Products]
 NCBI Protein Information    interleukin-10
 UniProt Protein Name    Interleukin-10
 UniProt Synonym Protein Names   
Cytokine synthesis inhibitory factor; CSIF
 Protein Family    Interleukin
 UniProt Gene Name    Il10 [Similar Products]
 UniProt Synonym Gene Names    Il-10; IL-10; CSIF [Similar Products]
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 NCBI Summary for Il10    This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Il10    IL10: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family.

Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1 E4|1 56.89 cM

Cellular Component: extracellular space

Molecular Function: cytokine activity; interleukin-10 receptor binding

Biological Process: defense response to bacterium; defense response to protozoan; immune response; inflammatory response; negative regulation of apoptosis; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of chronic inflammatory response to antigenic stimulus; negative regulation of cytokine production; negative regulation of cytokine secretion during immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of membrane protein ectodomain proteolysis; negative regulation of myeloid dendritic cell activation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; negative regulation of tumor necrosis factor production; positive regulation of B cell apoptosis; positive regulation of cell cycle; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of macrophage activation; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; receptor biosynthetic process; regulation of gene expression; regulation of sensory perception of pain; regulation of synapse organization and biogenesis; response to glucocorticoid stimulus; response to molecule of bacterial origin
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 Research Articles on Il10    1. the results of this study demonstrate that induction of IL-10 has a major influence on disease outcome during acute Staphylococcus aureus infection
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Il10 recombinant proteinPathways associated with Il10 recombinant protein
 Reference Product  PubMed Publications
 Jun recombinant protein  >2447 publications with Il10 and Jun
 Il6 recombinant protein  >906 publications with Il10 and Il6
 Stat3 recombinant protein  >566 publications with Il10 and Stat3
 Il4 recombinant protein  >534 publications with Il10 and Il4
 Gata3 recombinant protein  >83 publications with Il10 and Gata3
 Il19 recombinant protein  >75 publications with Il10 and Il19
 Il10rb recombinant protein  >59 publications with Il10 and Il10rb
 Il10ra recombinant protein  >35 publications with Il10 and Il10ra
 Il20rb recombinant protein  >1 publications with Il10 and Il20rb
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
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 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
Diseases associated with Il10 recombinant proteinOrgans/Tissues associated with Il10 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >8749 publications with Il10 and Necrosis
 Inflammation Antibodies  >7356 publications with Il10 and Inflammation
 Sepsis Antibodies  >1282 publications with Il10 and Sepsis
 Colitis Antibodies  >1054 publications with Il10 and Colitis
 Genetic Predisposition to Disease Antibodies  >1017 publications with Il10 and Genetic Predisposition to Disease
 Hypersensitivity, Immediate Antibodies  >898 publications with Il10 and Hypersensitivity, Immediate
 Inflammatory Bowel Diseases Antibodies  >870 publications with Il10 and Inflammatory Bowel Diseases
 Arthritis, Rheumatoid Antibodies  >642 publications with Il10 and Arthritis, Rheumatoid
 Kidney Diseases Antibodies  >536 publications with Il10 and Kidney Diseases
 HIV Infections Antibodies  >454 publications with Il10 and HIV Infections
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17513 publications with Il10 and Blood
 Bone Marrow Antibodies  >1167 publications with Il10 and Bone Marrow
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