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Il12b recombinant protein :: Interleukin-12 subunit beta (Il12b) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960040 Il12b recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $720 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $845 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $970 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $985 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,135 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,225 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,245 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,285 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,505 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,790 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,860 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,950 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,385 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-12 subunit beta (Il12b), Recombinant Protein

 Also Known As   

Recombinant Mouse Interleukin-12 subunit beta (Il12b)

 Product Synonym Names    Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40
 Product Gene Name   

Il12b recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    23-335aa; Full length protein
 Sequence    MWELEKDV YVVEVDWTPD APGETVNLTC DTPEEDDITW TSDQRHGVIG SGKTLTITVK EFLDAGQYTC HKGGETLSHS HLLLHKKENG IWSTEILKNF KNKTFLKCEA PNYSGRFTCS WLVQRNMDLK FNIKSSSSSP DSRAVTCGMA SLSAEKVTLD QRDYEKYSVS CQEDVTCPTA EETLPIELAL EARQQNKYEN YSTSFFIRDI IKPDPPKNLQ MKPLKNSQVE VSWEYPDSWS TPHSYFSLKF FVRIQRKKEK MKETEEGCNQ KGAFLVEKTS TEVQCKGGNV CVQAQDRYYN SSCSKWACVP CRVRS
 3D Structure    ModBase 3D Structure for P43432
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Il12b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Il12b recombinant protein

   This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
NCBI/Uniprot data below describe general gene information for Il12b. It may not necessarily be applicable to this product.
 NCBI GI #    6680397
 NCBI GeneID    16160
 NCBI Accession #    NP_032378.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008352.2 [Other Products]
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 UniProt Primary Accession #    P43432 [Other Products]
 UniProt Secondary Accession #    Q9QUM1 [Other Products]
 UniProt Related Accession #    P43432 [Other Products]
 Molecular Weight    38,235 Da
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 NCBI Official Full Name    interleukin-12 subunit beta
 NCBI Official Synonym Full Names    interleukin 12b
 NCBI Official Symbol    Il12b [Similar Products]
 NCBI Official Synonym Symbols   
p40; Il-12b; Il12p40; Il-12p40
[Similar Products]
 NCBI Protein Information    interleukin-12 subunit beta; CLMF p40; IL-12 p40; IL-12 subunit p40; IL-23 subunit p40; cytotoxic lymphocyte maturation factor 40 kDa subunit
 UniProt Protein Name    Interleukin-12 subunit beta
 UniProt Synonym Protein Names   
Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40
 Protein Family    Interleukin
 UniProt Gene Name    Il12b [Similar Products]
 UniProt Synonym Gene Names    IL-12B; CLMF p40 [Similar Products]
 UniProt Entry Name    IL12B_MOUSE
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 NCBI Summary for Il12b    This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]
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 UniProt Comments for Il12b    IL12B: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Genetic variations in IL12B are a cause of susceptibility to psoriasis type 11 (PSORS11). Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; membrane; interleukin-12 complex; cytoplasm; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; interleukin-12 alpha subunit binding; protein binding; protein homodimerization activity; growth factor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein heterodimerization activity; cytokine activity; interleukin-23 receptor binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of cell adhesion; negative regulation of interleukin-10 production; positive regulation of T-helper 1 type immune response; positive regulation of interleukin-12 production; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; negative regulation of smooth muscle cell proliferation; positive regulation of NK T cell proliferation; positive regulation of tyrosine phosphorylation of Stat4 protein; natural killer cell activation; defense response to Gram-negative bacterium; sensory perception of pain; positive regulation of activated T cell proliferation; positive regulation of interleukin-10 production; positive regulation of natural killer cell activation; positive regulation of tyrosine phosphorylation of Stat3 protein; cell surface receptor linked signal transduction; positive regulation of lymphocyte proliferation; natural killer cell activation during immune response; negative regulation of inflammatory response to antigenic stimulus; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; positive regulation of interleukin-17 production; positive regulation of NK T cell activation; cell migration; positive regulation of natural killer cell proliferation; T-helper cell differentiation; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; defense response to protozoan; positive regulation of tumor necrosis factor production; regulation of tyrosine phosphorylation of Stat1 protein; response to UV-B; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of mononuclear cell proliferation; positive regulation of defense response to virus by host
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 Research Articles on Il12b    1. the assembled p40-CD5L heterodimer does not recapitulate the biological activity of IL-12.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Il12b recombinant proteinPathways associated with Il12b recombinant protein
 Reference Product  PubMed Publications
 Rel recombinant protein  >3 publications with Il12b and Rel
 Irf5 recombinant protein  >2 publications with Il12b and Irf5
 Rela recombinant protein  >1 publications with Il12b and Rela
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 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
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 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
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 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with Il12b recombinant proteinOrgans/Tissues associated with Il12b recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >65 publications with Il12b and Immune System Diseases
 Psoriasis Antibodies  >36 publications with Il12b and Psoriasis
 Bacterial Infections Antibodies  >32 publications with Il12b and Bacterial Infections
 Inflammation Antibodies  >30 publications with Il12b and Inflammation
 Intestinal Diseases Antibodies  >27 publications with Il12b and Intestinal Diseases
 Inflammatory Bowel Diseases Antibodies  >24 publications with Il12b and Inflammatory Bowel Diseases
 Diabetes Mellitus Antibodies  >21 publications with Il12b and Diabetes Mellitus
 Tuberculosis Antibodies  >19 publications with Il12b and Tuberculosis
 Lung Diseases Antibodies  >19 publications with Il12b and Lung Diseases
 Respiratory Tract Diseases Antibodies  >18 publications with Il12b and Respiratory Tract Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >19 publications with Il12b and Skin
 Lymph Node Antibodies  >3 publications with Il12b and Lymph Node
 Mixed Antibodies  >2 publications with Il12b and Mixed
 Bone Marrow Antibodies  >2 publications with Il12b and Bone Marrow
 Spleen Antibodies  >1 publications with Il12b and Spleen
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