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Il12b recombinant protein :: Interleukin-12 subunit beta (Il12b) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960040 Il12b recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $720 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $970 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $985 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,135 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,225 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,245 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,285 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,505 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,790 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,860 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,950 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,385 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-12 subunit beta (Il12b), Recombinant Protein

 Also Known As   

Recombinant Mouse Interleukin-12 subunit beta (Il12b)

 Product Gene Name   

Il12b recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    23-335aa, Full Length of Mature Protein
 Sequence    MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
 3D Structure    ModBase 3D Structure for P43432
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Il12b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Il12b recombinant protein

   This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory
effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
NCBI/Uniprot data below describe general gene information for Il12b. It may not necessarily be applicable to this product.
 NCBI GI #    735997434
 NCBI GeneID    16160
 NCBI Accession #    NP_001290173.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001303244.1 [Other Products]
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 UniProt Primary Accession #    P43432 [Other Products]
 UniProt Secondary Accession #    Q9QUM1 [Other Products]
 UniProt Related Accession #    P43432 [Other Products]
 Molecular Weight    38,235 Da
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 NCBI Official Full Name    interleukin-12 subunit beta
 NCBI Official Synonym Full Names    interleukin 12b
 NCBI Official Symbol    Il12b [Similar Products]
 NCBI Official Synonym Symbols   
p40; Il-12b; Il12p40; Il-12p40
[Similar Products]
 NCBI Protein Information    interleukin-12 subunit beta
 UniProt Protein Name    Interleukin-12 subunit beta
 UniProt Synonym Protein Names   
Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40
 Protein Family    Interleukin
 UniProt Gene Name    Il12b [Similar Products]
 UniProt Synonym Gene Names    IL-12B; CLMF p40 [Similar Products]
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 NCBI Summary for Il12b    This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]
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 UniProt Comments for Il12b    Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
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 Research Articles on Il12b    1. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro.(
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Il12b recombinant proteinPathways associated with Il12b recombinant protein
 Reference Product  PubMed Publications
 Il12a recombinant protein  >59 publications with Il12b and Il12a
 Il6 recombinant protein  >46 publications with Il12b and Il6
 Il12rb1 recombinant protein  >41 publications with Il12b and Il12rb1
 Jun recombinant protein  >40 publications with Il12b and Jun
 Il23a recombinant protein  >34 publications with Il12b and Il23a
 Il12rb2 recombinant protein  >14 publications with Il12b and Il12rb2
 Nfkb1 recombinant protein  >8 publications with Il12b and Nfkb1
 Rela recombinant protein  >4 publications with Il12b and Rela
 Fos recombinant protein  >1 publications with Il12b and Fos
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with Il12b recombinant proteinOrgans/Tissues associated with Il12b recombinant protein
 Disease Name  Pubmed Publications
 Psoriasis Antibodies  >77 publications with Il12b and Psoriasis
 Inflammation Antibodies  >68 publications with Il12b and Inflammation
 Necrosis Antibodies  >48 publications with Il12b and Necrosis
 Crohn Disease Antibodies  >32 publications with Il12b and Crohn Disease
 Lung Diseases Antibodies  >32 publications with Il12b and Lung Diseases
 Arthritis, Psoriatic Antibodies  >25 publications with Il12b and Arthritis, Psoriatic
 Liver Diseases Antibodies  >21 publications with Il12b and Liver Diseases
 Colitis, Ulcerative Antibodies  >19 publications with Il12b and Colitis, Ulcerative
 Disease Models, Animal Antibodies  >16 publications with Il12b and Disease Models, Animal
 Asthma Antibodies  >16 publications with Il12b and Asthma
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >44 publications with Il12b and Skin
 Bone Marrow Antibodies  >12 publications with Il12b and Bone Marrow
 Lymph Node Antibodies  >7 publications with Il12b and Lymph Node
 Spleen Antibodies  >5 publications with Il12b and Spleen
 Mixed Antibodies  >2 publications with Il12b and Mixed
 Thymus Antibodies  >1 publications with Il12b and Thymus
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