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IL-13 recombinant protein :: Interleukin-13 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553168 IL-13 recombinant protein
Unit / Price
0.002 mg  /  $145 +1 FREE 8GB USB
0.01 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-13 (IL-13), Recombinant Protein

★Popular Item★
 Also Known As   

Human Interleukin-13 Recombinant

 Product Synonym Names    il13; il-13; nc30; interleukin-13
 Product Gene Name   

IL-13 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MALLLTTVIA LTCLGGFASP GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN
 OMIM    147683
 3D Structure    ModBase 3D Structure for P35225
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 Host    E Coli
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 Purity/Purification    >95%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Interleukin-13 was lyophilized from a 0.2um filtered concentrated (1mg/ml) solution in PBS, pH 7.2.
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 Domain    4 helix cytokine core
 Host Note    Optimized DNA sequence encoding Human Interleukin-13 mature chain was expressed in Escherichia Coli.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Native human Interleukin-13, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 13 kDa.

Recombinant IL-13 is a disulfide-linked monomer protein consisting of 115 amino acid residue subunits,and migrates as an approximately 13 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IL-13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL-13 recombinant protein

   Mouse IL13 is produced primarily by activated Th2 cells. Human IL13 is expressed in activated T- helper cells (resembling Th0, Th1, Th2), and T-cells expressing CD8. The alpha chain of the IL13 receptor has weak binding activity for IL13. High affinity receptors are formed when the receptor alpha chains of IL13 and IL4 receptors are coexpressed. The receptors for IL13 and IL4 share a component,a common gamma subunit that is found also in the IL2 receptor.Different IL13 receptor structures have been shown to exist on various cell types and the IL13 receptor may share more than one component with IL4 receptor. IL13 down-modulates macrophage activity, reducing the production of pro-inflammatory cytokines and chemokines in response to IFN-gamma or bacterial lypopolysaccharides. IL13 enhances the production of the IL1 receptor antagonist IL1ra. IL13 also decreases the production of nitric oxide by activated macrophages, leading to a decrease in parasiticidal activity. IL13 induces differentiation of human monocytes, enhances survival time in culture, and also induces differentiation and proliferation and Isotype switching in B-cells.
 Product Categories/Family for IL-13 recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for IL-13. It may not necessarily be applicable to this product.
 NCBI GI #    26787978
 NCBI GeneID    3596
 NCBI Accession #    NP_002179.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002188.2 [Other Products]
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 UniProt Primary Accession #    P35225 [Other Products]
 UniProt Secondary Accession #    O43644; Q4VB52; Q9UDC7 [Other Products]
 UniProt Related Accession #    P35225; Q4VB50; Q4VB51; Q4VB53 [Other Products]
 Molecular Weight    15,816 Da
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 NCBI Official Full Name    interleukin-13
 UniProt Protein Name    Interleukin-13
 Protein Family    Interleukin
 UniProt Gene Name    IL13 [Similar Products]
 UniProt Synonym Gene Names    NC30; IL-13 [Similar Products]
 UniProt Entry Name    IL13_HUMAN
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 NCBI Summary for IL-13    This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL-13    IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: protein binding; interleukin-13 receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; regulation of proton transport; microglial cell activation; response to lipopolysaccharide; signal transduction; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; cell-cell signaling; positive regulation of B cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; cell motility; negative regulation of NAD(P)H oxidase activity; inflammatory response; positive regulation of macrophage activation

Disease: Asthma, Susceptibility To; Allergic Rhinitis
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Product References and Citations for IL-13 recombinant protein

   IL-13-induced oxidative stress via microglial nadph oxidase contributes to death of hippocampal neurons in vivo .J. Immunol., Oct 2009; 183: 4666 - 4674.
involvement of IL-13 in tobacco smoke induced changes in the structure and function of rat intrapulmonary airways .Am. J. Respir. Cell Mol. Biol., Sep 2009; 10.1165/rcmb.2009-0117 degree C.
disruption of th2 immunity results in a gender-specific expansion of IL-13 producing accessory nk cells during helminth infection .J. Immunol., Sep 2009; 183: 3906 - 3914.
distinct structural requirements for interleukin-4 (il-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness .J. Biol. Chem., Sep 2009; 284: 24289 - 24296.
IL-13 receptor 2 regulates the immune and functional response to nippostrongylus brasiliensis infection .J. Immunol., Aug 2009; 183: 1934 - 1939.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL-13 recombinant proteinPathways associated with IL-13 recombinant protein
 Reference Product  PubMed Publications
 IL13RA1 recombinant protein  >272 publications with IL-13 and IL13RA1
 IL4R recombinant protein  >41 publications with IL-13 and IL4R
 IL13RA2 recombinant protein  >10 publications with IL-13 and IL13RA2
 VCAM1 recombinant protein  >4 publications with IL-13 and VCAM1
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with IL-13 recombinant proteinOrgans/Tissues associated with IL-13 recombinant protein
 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >984 publications with IL-13 and Hypersensitivity
 Inflammation Antibodies  >914 publications with IL-13 and Inflammation
 Asthma Antibodies  >895 publications with IL-13 and Asthma
 Hypersensitivity, Immediate Antibodies  >849 publications with IL-13 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >839 publications with IL-13 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >711 publications with IL-13 and Respiratory Hypersensitivity
 Neoplasms Antibodies  >382 publications with IL-13 and Neoplasms
 Eosinophilia Antibodies  >235 publications with IL-13 and Eosinophilia
 Fibrosis Antibodies  >228 publications with IL-13 and Fibrosis
 Bronchial Hyperreactivity Antibodies  >178 publications with IL-13 and Bronchial Hyperreactivity
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >137 publications with IL-13 and Brain
 Bone Marrow Antibodies  >109 publications with IL-13 and Bone Marrow
 Mixed Antibodies  >58 publications with IL-13 and Mixed
 Testis Antibodies  >5 publications with IL-13 and Testis
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