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IL15 recombinant protein :: Interleukin-15 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203120
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-15 (IL15), Recombinant Protein

 Also Known As   

Interleukin-15, 49-162aa, Human, His tag, E Coli (Bioactivity Validated)

 Product Synonym Names    IL-15; Interleukin-15; IL15
 Product Gene Name   

IL15 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTSLEHHH HHH
 OMIM    U14407 mRNA
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
 Biological Activity    Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 2.5 ng/ml.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of IL15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL15 recombinant protein

   Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 receptor alpha (IL-15R alpha) from one subset of cells presents IL-15 to neighboring IL-2R beta/gamma (c)-expressing cells. This newly discovered cytokine is produced by a wide variety of cells and tissues and like IL-2, stimulates the proliferation of T-lymphocytes and induces the generation of cytotoxic T-lymphocytes (CTLs) and lymphokine-activated killer (LAK) cells. Recombinant human IL-15 was expressed in E Coli and purified by using conventional chromatography after refolding of the isolated inclusion bodies in a redox buffer.
 Product Categories/Family for IL15 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for IL15 recombinant protein   

SDS-PAGE

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 SDS-Page of IL15 recombinant protein    IL15 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for IL15. It may not necessarily be applicable to this product.
 NCBI GI #    26787984
 NCBI GeneID    3600
 NCBI Accession #    NP_751914 [Other Products]
 NCBI GenBank Nucleotide #    NM_172174.2 [Other Products]
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 UniProt Secondary Accession #    O00440; O43512; Q495Z8; Q6FGX7; Q93058; Q9UBA3; D3DNZ2 [Other Products]
 UniProt Related Accession #    P40933 [Other Products]
 Molecular Weight    13.9kDa (123aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Synonym Full Names    interleukin 15
 NCBI Official Symbol    IL15 [Similar Products]
 NCBI Official Synonym Symbols   
IL-15
[Similar Products]
 NCBI Protein Information    interleukin-15
 UniProt Protein Name    Interleukin-15
 Protein Family    Interleukin
 UniProt Gene Name    IL15 [Similar Products]
 UniProt Synonym Gene Names    IL-15 [Similar Products]
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 NCBI Summary for IL15    The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
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 UniProt Comments for IL15    Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
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Product References and Citations for IL15 recombinant protein

   J G Giri., et al. (1994) EMBO. 13 (12): 2822-2830.; Lorenzen I., et al. (2006). J Biol Chem. 281 (10):6642-7.;
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 Research Articles on IL15    1. IL-15 levels were found to be elevated in depressed patients with asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL15 recombinant proteinPathways associated with IL15 recombinant protein
 Reference Product  PubMed Publications
 IL15RA recombinant protein  >255 publications with IL15 and IL15RA
 IL21R recombinant protein  >88 publications with IL15 and IL21R
 IL2RB recombinant protein  >34 publications with IL15 and IL2RB
 IL2RG recombinant protein  >32 publications with IL15 and IL2RG
 IL4 recombinant protein  >31 publications with IL15 and IL4
 IL2RA recombinant protein  >27 publications with IL15 and IL2RA
 IL12RB1 recombinant protein  >5 publications with IL15 and IL12RB1
 IL7R recombinant protein  >3 publications with IL15 and IL7R
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Development And Heterogeneity Of The ILC Family Pathway antibodies  Development And Heterogeneity Of The ILC Family Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with IL15 recombinant proteinOrgans/Tissues associated with IL15 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >452 publications with IL15 and Inflammation
 Necrosis Antibodies  >400 publications with IL15 and Necrosis
 Disease Models, Animal Antibodies  >237 publications with IL15 and Disease Models, Animal
 Death Antibodies  >181 publications with IL15 and Death
 Lung Diseases Antibodies  >120 publications with IL15 and Lung Diseases
 Neoplasms, Experimental Antibodies  >117 publications with IL15 and Neoplasms, Experimental
 Celiac Disease Antibodies  >93 publications with IL15 and Celiac Disease
 Liver Diseases Antibodies  >80 publications with IL15 and Liver Diseases
 Hypersensitivity Antibodies  >63 publications with IL15 and Hypersensitivity
 Lung Neoplasms Antibodies  >57 publications with IL15 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >173 publications with IL15 and Lung
 Muscle Antibodies  >157 publications with IL15 and Muscle
 Vascular Antibodies  >108 publications with IL15 and Vascular
 Thymus Antibodies  >82 publications with IL15 and Thymus
 Brain Antibodies  >81 publications with IL15 and Brain
 Kidney Antibodies  >79 publications with IL15 and Kidney
 Uterus Antibodies  >79 publications with IL15 and Uterus
 Adipose Tissue Antibodies  >54 publications with IL15 and Adipose Tissue
 Placenta Antibodies  >44 publications with IL15 and Placenta
 Embryonic Tissue Antibodies  >41 publications with IL15 and Embryonic Tissue
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