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IL15 recombinant protein :: Interleukin 15 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS651085 IL15 recombinant protein
Unit / Price
0.002 mg  /  $280 +1 FREE 8GB USB
0.01 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 15 (IL15), Recombinant Protein

 Also Known As   

Interleukin 15, Recombinant, Mouse (IL-15)

 Product Gene Name   

IL15 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MNWIDVRYDL EKIESLIQSI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VAESGCKECE ELEEKTFTEF LQSFIRIVQM FINTS
 Chromosome Location    Chromosome: 4; NC_000004.11 (142557754..142654612). Location: 4q31
 OMIM    600554
 3D Structure    ModBase 3D Structure for P40933
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 Host    Recombinant, Murine (E Coli
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 Purity/Purification    Molecular Biology Grade
~ 98%, SDS-PAGE, HPLC. Endotoxin: 0.1ng/ug (1EU/ug)
 Form/Format    Supplied as a lyophilized powder. Reconstitute with sterile dH2O.
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 Biological Activity    The ED50 was determined by the stimulation of the proliferation of murine CTLL-2 cells is 5ng/ml, corresponding to a specific activity of  2x10e5 units/mg.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Reconstitutewith sterile ddH2O. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of IL15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IL15 recombinant protein

   IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant murine IL-15 is a 13.3kD protein consisting of 115 amino acid residues.
 Product Categories/Family for IL15 recombinant protein    Growth Factors, Cytokines; Growth Factors-Interleukin
NCBI/Uniprot data below describe general gene information for IL15. It may not necessarily be applicable to this product.
 NCBI GI #    10835153
 NCBI GeneID    3600
 NCBI Accession #    NP_000576.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000585.4 [Other Products]
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 UniProt Primary Accession #    P40933 [Other Products]
 UniProt Secondary Accession #    O00440; O43512; Q495Z8; Q93058; Q9UBA3; D3DNZ2 [Other Products]
 UniProt Related Accession #    P40933; Q6FGX7 [Other Products]
 Molecular Weight    18,086 Da [Similar Products]
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 NCBI Official Full Name    interleukin-15 isoform 1 preproprotein
 NCBI Official Synonym Full Names    interleukin 15
 NCBI Official Symbol    IL15 [Similar Products]
 NCBI Official Synonym Symbols   
IL-15; MGC9721
[Similar Products]
 NCBI Protein Information    interleukin-15; OTTHUMP00000164616; OTTHUMP00000164617; OTTHUMP00000228804
 UniProt Protein Name    Interleukin-15
 Protein Family    Interleukin
 UniProt Gene Name    IL15 [Similar Products]
 UniProt Entry Name    IL15_HUMAN
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 NCBI Summary for IL15    The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq]
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 UniProt Comments for IL15    Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Subcellular location: Isoform IL15-S48AA: Secreted. Isoform IL15-S21AA: Cytoplasm. Nucleus. Note: IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.

Sequence similarities: Belongs to the IL-15/IL-21 family.

Sequence caution: The sequence CAA71044.1 differs from that shown. Reason: Man-made cDNA construct with a sequence coding for signal peptide increasing the secretion of the protein (substitution with a signal peptide derived from the mouse IgV kappa chain).
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 Research Articles on IL15    1. Data show that in patients with PsA, serum TWEAK, IL-15, MCP-1 and MMP-3 levels were significantly elevated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL15 recombinant proteinPathways associated with IL15 recombinant protein
 Reference Product  PubMed Publications
 IL15RA recombinant protein  >212 publications with IL15 and IL15RA
 IL2RB recombinant protein  >71 publications with IL15 and IL2RB
 IL2RG recombinant protein  >55 publications with IL15 and IL2RG
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
Diseases associated with IL15 recombinant proteinOrgans/Tissues associated with IL15 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >350 publications with IL15 and Neoplasms
 Necrosis Antibodies  >289 publications with IL15 and Necrosis
 Inflammation Antibodies  >254 publications with IL15 and Inflammation
 Respiratory Tract Diseases Antibodies  >76 publications with IL15 and Respiratory Tract Diseases
 Neoplasms, Experimental Antibodies  >74 publications with IL15 and Neoplasms, Experimental
 Leukemia, T-Cell Antibodies  >57 publications with IL15 and Leukemia, T-Cell
 Hypersensitivity Antibodies  >44 publications with IL15 and Hypersensitivity
 Liver Diseases Antibodies  >37 publications with IL15 and Liver Diseases
 Adenocarcinoma Antibodies  >35 publications with IL15 and Adenocarcinoma
 Lung Neoplasms Antibodies  >34 publications with IL15 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >39 publications with IL15 and Mixed
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