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mIL 17 A/F recombinant protein :: Interleukin-17 A/F Heterodimer Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143623 mIL 17 A/F recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $940 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-17 A/F Heterodimer (mIL 17 A/F), Recombinant Protein

 Also Known As   

Recombinant Mouse Interleukin-17 A/F Heterodimer

 Product Synonym Names    IL 17 A/F Mouse; Interleukin-17 A/F Heterodimer Mouse Recombinant; IL17A/F; IL17 A/F; IL-17A/F; IL-17 A/F; IL17AF; IL-17 AF; Interleukin-17 A/F; Interleukin-17 AF
 Product Gene Name   

mIL 17 A/F recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    RKNPKAGVPA LQKAGNCPPL EDNTVRVDIR IFNQNQGISV PREFQNRSSS PWDYNITRDP HRFPSEIAEA QCRHSGCINA QGQEDSTMNS VAIQQEILVL RREPQGCSNS FRLEKMLLKV GCTCVKPIVH QAAAAIIPQS SACPNTEAKD FLQNVKVNLK VFNSLGAKVS SRRPSDYLNR STSPWTLHRN EDPDRYPSVI WEAQCRHQRC VNAEGKLDHH MNSVLIQQEI LVLKREPESC PFTFRVEKML VGVGCTCVAS IVRQAA.
 OMIM    603149
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Mouse IL17 A/F in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized Mouse IL17 A/F although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Mouse IL17 A/F should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of mIL 17 A/F recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for mIL 17 A/F recombinant protein

   Description: Interleukin-17 A/F Mouse Recombinant produced in E Coli is a heterodimeric, non-glycosylated polypeptide comprised of IL17A monomeric subunit & and IL17F monomeric subunit containing a total of 266 amino acids and having a total molecular mass of 29.8kDa. The IL-17 A/F is purified by proprietary chromatographic techniques.

Introduction: Human IL-17A/F is a 40kDa glycoprotein which is secreted as a disulfide-linked heterodimer. IL-17A/F consists of two proteins of the IL-17 family, IL-17A and IL17F. Proteins of the 6 homodimeric IL17 family show a cysteine knot motif that contains two disulfide-bonds. Human IL17A is produced as a 155 a.a precursor that includes a 23 amino acids signal sequence and a 132 amino acid chain that includes an N-linked glycosylation site. Human IL17F is produced as a 153 amino acid precursor with a 20 amino acid signal sequence and a 133 amino acid region. Similar to IL17A, IL17F also has an N-linked glycosylation site. Both proteins (IL17A & IL17F) share 50% amino acid sequence identity. Human IL17A & IL17F show approximately 60% homology in their amino acid sequence to mouse IL-17A and IL-17F. Interleukin-17A/F and IL17A, IL17F homodimers are manufactured by activted CD4+ T cells, called Th17. IL-23 causes Th17 lymphocytes to manufacture IL-17A/F. IL17RA and IL17RC form a heterodimer for the binding of IL17A and IL17F. IL-17A/F binds IL-17RA. Interleukin-17A/F induces chemokine production and airway neutrophilia with intermediate potency between IL17A (most potent) and IL17F (least potent).
 Product Categories/Family for mIL 17 A/F recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for mIL 17 A/F. It may not necessarily be applicable to this product.
 NCBI GI #    299832923
 NCBI GeneID    3605
 NCBI Accession #    ADJ56412.1 [Other Products]
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 UniProt Secondary Accession #    Q5T2P0 [Other Products]
 UniProt Related Accession #    Q16552 [Other Products]
 Molecular Weight    17,504 Da
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 NCBI Official Full Name    interleukin 17A, partial
 NCBI Official Synonym Full Names    interleukin 17A
 NCBI Official Symbol    IL17A [Similar Products]
 NCBI Official Synonym Symbols   
IL17; CTLA8; IL-17; IL-17A
[Similar Products]
 NCBI Protein Information    interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
 UniProt Protein Name    Interleukin-17A
 UniProt Synonym Protein Names   
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
 UniProt Gene Name    IL17A [Similar Products]
 UniProt Synonym Gene Names    CTLA8; IL17; IL-17; IL-17A; CTLA-8 [Similar Products]
 UniProt Entry Name    IL17_HUMAN
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 NCBI Summary for mIL 17 A/F    The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for mIL 17 A/F    IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; positive regulation of interleukin-23 production; apoptosis; positive regulation of osteoclast differentiation; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
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 Research Articles on mIL 17 A/F    1. Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-beta levels were lower in type 1 diabetic patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mIL 17 A/F recombinant proteinPathways associated with mIL 17 A/F recombinant protein
 Reference Product  PubMed Publications
 FOXP3 recombinant protein  >680 publications with mIL 17 A/F and FOXP3
 STAT3 recombinant protein  >289 publications with mIL 17 A/F and STAT3
 TGFB1 recombinant protein  >150 publications with mIL 17 A/F and TGFB1
 IL6 recombinant protein  >120 publications with mIL 17 A/F and IL6
 IL17RA recombinant protein  >117 publications with mIL 17 A/F and IL17RA
 STAT1 recombinant protein  >89 publications with mIL 17 A/F and STAT1
 IL23A recombinant protein  >71 publications with mIL 17 A/F and IL23A
 IL17RC recombinant protein  >26 publications with mIL 17 A/F and IL17RC
 NFKB1 recombinant protein  >3 publications with mIL 17 A/F and NFKB1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL17 Signaling Pathway antibodies  IL17 Signaling Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram
Diseases associated with mIL 17 A/F recombinant proteinOrgans/Tissues associated with mIL 17 A/F recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2525 publications with mIL 17 A/F and Inflammation
 Autoimmune Diseases Antibodies  >1898 publications with mIL 17 A/F and Autoimmune Diseases
 Disease Models, Animal Antibodies  >1364 publications with mIL 17 A/F and Disease Models, Animal
 Necrosis Antibodies  >1051 publications with mIL 17 A/F and Necrosis
 Respiratory Tract Diseases Antibodies  >744 publications with mIL 17 A/F and Respiratory Tract Diseases
 Lung Diseases Antibodies  >654 publications with mIL 17 A/F and Lung Diseases
 Central Nervous System Diseases Antibodies  >555 publications with mIL 17 A/F and Central Nervous System Diseases
 Hypersensitivity Antibodies  >522 publications with mIL 17 A/F and Hypersensitivity
 Liver Diseases Antibodies  >202 publications with mIL 17 A/F and Liver Diseases
 Fibrosis Antibodies  >182 publications with mIL 17 A/F and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >107 publications with mIL 17 A/F and Mixed
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