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Interleukin 17 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650072 Interleukin 17 recombinant protein
Unit / Price
0.005 mg  /  $315 +1 FREE 8GB USB
0.025 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 17, Recombinant Protein

★Popular Item★
 Also Known As   

Interleukin 17, Recombinant, Human (IL-17, CTLA8, IL-17A, Interleukin-17A precursor, Cytotoxic T-lymphocyte-associated antigen 8)

 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS650072 Technical Datasheet    Technical Datasheet PDF
 Sequence    MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
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 Host    E Coli
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 Purity/Purification    Highly Purified
98% by SDS-PAGE and HPLC analyses. Endotoxin: 0.1ng/ug
 Form/Format    Supplied as a lyophilized powder. Reconstitute with sterile ddH2O, carrier protein
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 Biological Activity    Assay #1: The ED50 was determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast and is ~2ng/ml.
Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O, carrier protein. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of Interleukin 17 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Interleukin 17 recombinant protein

   The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136aa chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31kD disulfide-linked homodimer of two 136aa polypeptide chains.
 Product Categories/Family for Interleukin 17 recombinant protein    Growth Factors, Cytokines; Growth Factors-Interleukin
NCBI/Uniprot data below describe general gene information for Interleukin 17. It may not necessarily be applicable to this product.
 NCBI GI #    55139064
 Molecular Weight    31.0kD [Similar Products]
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 NCBI Official Full Name    interleukin-17
 Protein Family    Interleukin 17-like protein
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 NCBI Summary for Interleukin 17    The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Interleukin 17    IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Interleukin 17 recombinant proteinPathways associated with Interleukin 17 recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with Interleukin 17 and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Organs/Tissues associated with Interleukin 17 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with Interleukin 17 and Bone
 Connective Tissue Antibodies  >4 publications with Interleukin 17 and Connective Tissue
 Heart Antibodies  >3 publications with Interleukin 17 and Heart
 Muscle Antibodies  >3 publications with Interleukin 17 and Muscle
 Brain Antibodies  >3 publications with Interleukin 17 and Brain
 Vascular Antibodies  >2 publications with Interleukin 17 and Vascular
 Embryonic Tissue Antibodies  >2 publications with Interleukin 17 and Embryonic Tissue
 Ear Antibodies  >1 publications with Interleukin 17 and Ear
 Kidney Antibodies  >1 publications with Interleukin 17 and Kidney
 Umbilical Cord Antibodies  >1 publications with Interleukin 17 and Umbilical Cord
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