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mIL 17F recombinant protein :: Interleukin-17F Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143666 mIL 17F recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-17F (mIL 17F), Recombinant Protein

 Also Known As   

Recombinant Mouse Interleukin-17F

 Product Synonym Names    IL17F Mouse; Interleukin-17F Mouse Recombinant; Cytokine ML-1; IL-17F; Interleukin-17F precursor; IL17F; ML1; ML-1
 Product Gene Name   

mIL 17F recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q7TNI7
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    IL17F was lyophilized from a concentrated (1mg/ml) solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Mouse IL17F in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized Murine IL17F although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL17F should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of mIL 17F recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mIL 17F recombinant protein

   Description: IL17F Mouse Recombinant produced in E Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 266 amino acids and having a molecular mass of 29.8 kDa. The Mouse IL-17F is purified by proprietary chromatographic techniques.

Introduction: IL-17F having an accession number of Q96PD4 is a cytokine that shares sequence similarity with IL17. IL-17F is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM-CSF. IL-17F inhibits the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. IL-17F induces stromal cells to produce proinflammatory and hematopoietic cytokines. Intestinal IL17F gene expression is increased in active CD.IL-17A & IL-17F alleles influence the susceptibility to and pathophysiological features of ulcerative colitis independently. IL-17F and MIF gene polymorphisms are significantly associated with the development of functional dyspepsia. The initiation of IL-17F/IL-17R signaling pathway requires the receptor ubiquitination by TRAF6. IL-17F induces expression of IFN-gamma-inducible protein 10 (IP-10) by activating Raf1-mitogen-activated protein kinase 1/2-extracellular-regulated kinase 1/2-p90 ribosomal S6 kinase-cyclic AMP response element-binding protein signaling pathway.
 Product Categories/Family for mIL 17F recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for mIL 17F. It may not necessarily be applicable to this product.
 NCBI GI #    119360346
 NCBI GeneID    257630
 NCBI Accession #    NP_665855.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_145856.2 [Other Products]
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 UniProt Primary Accession #    Q7TNI7 [Other Products]
 UniProt Secondary Accession #    Q8K4C3 [Other Products]
 UniProt Related Accession #    Q7TNI7 [Other Products]
 Molecular Weight    17,020 Da
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 NCBI Official Full Name    interleukin-17F
 NCBI Official Synonym Full Names    interleukin 17F
 NCBI Official Symbol    Il17f [Similar Products]
 NCBI Official Synonym Symbols   
C87042; IL-17F
[Similar Products]
 NCBI Protein Information    interleukin-17F
 UniProt Protein Name    Interleukin-17F
 Protein Family    Interleukin
 UniProt Gene Name    Il17f [Similar Products]
 UniProt Synonym Gene Names    IL-17F [Similar Products]
 UniProt Entry Name    IL17F_MOUSE
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 UniProt Comments for mIL 17F    IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity

Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of interleukin-8 biosynthetic process; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; regulation of interleukin-2 biosynthetic process; cytokine biosynthetic process; lymphotoxin A biosynthetic process; cartilage development; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
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 Research Articles on mIL 17F    1. Data indicate that IL-17A repressed IL-17F secretion in vitro and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mIL 17F recombinant proteinPathways associated with mIL 17F recombinant protein
 Reference Product  PubMed Publications
 Il17ra recombinant protein  >10 publications with mIL 17F and Il17ra
 Stat3 recombinant protein  >9 publications with mIL 17F and Stat3
 Il17rc recombinant protein  >7 publications with mIL 17F and Il17rc
 Il17re recombinant protein  >2 publications with mIL 17F and Il17re
 Il17rd recombinant protein  >1 publications with mIL 17F and Il17rd
 Products by Pathway  Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
Diseases associated with mIL 17F recombinant proteinOrgans/Tissues associated with mIL 17F recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >65 publications with mIL 17F and Inflammation
 Hypersensitivity Antibodies  >21 publications with mIL 17F and Hypersensitivity
 Lung Diseases Antibodies  >19 publications with mIL 17F and Lung Diseases
 Necrosis Antibodies  >16 publications with mIL 17F and Necrosis
 Disease Models, Animal Antibodies  >13 publications with mIL 17F and Disease Models, Animal
 Liver Diseases Antibodies  >7 publications with mIL 17F and Liver Diseases
 Fibrosis Antibodies  >5 publications with mIL 17F and Fibrosis
 Death Antibodies  >4 publications with mIL 17F and Death
 Atherosclerosis Antibodies  >4 publications with mIL 17F and Atherosclerosis
 Neoplasms, Experimental Antibodies  >3 publications with mIL 17F and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >6 publications with mIL 17F and Spleen
 Ovary Antibodies  >1 publications with mIL 17F and Ovary
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