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IL18 recombinant protein :: Interleukin 18 (IL18) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010987 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $340 +1 FREE 8GB USB
0.2 mg  /  $415 +1 FREE 8GB USB
0.5 mg  /  $800 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 18 (IL18), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Interleukin 18 (IL18)

 Product Gene Name   

IL18 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Interleukin 18 (IL18) (MBS2006728)
Antigen: Interleukin 18 (IL18) (MBS2010987)
 Matching Pairs    Antibody: Interleukin 18 (MBS2025857)
Antigen: Interleukin 18 (IL18) (MBS2010987)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG S-YFGK LESKLSVIRN LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED
 Chromosome Location    Chromosome: 11; NC_000011.9 (112013974..112034840, complement). Location: 11q22.2-q22.3
 OMIM    600953
 3D Structure    ModBase 3D Structure for Q14116
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Tyr37~Asp193 (Accession # Q14116) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of IL18 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL18 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for IL18 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of IL18 recombinant protein    IL18 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.
 NCBI GI #    342349321
 NCBI GeneID    3606
 NCBI Accession #    NP_001230140.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243211.1 [Other Products]
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 UniProt Primary Accession #    Q14116 [Other Products]
 UniProt Secondary Accession #    O75599; Q6FGY3; Q6WWJ7 [Other Products]
 UniProt Related Accession #    Q14116 [Other Products]
 Molecular Weight    19.5kDa
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 NCBI Official Full Name    interleukin-18 isoform 2 proprotein
 NCBI Official Synonym Full Names    interleukin 18 (interferon-gamma-inducing factor)
 NCBI Official Symbol    IL18 [Similar Products]
 NCBI Official Synonym Symbols   
IGIF; IL-18; IL-1g; IL1F4
[Similar Products]
 NCBI Protein Information    interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor
 UniProt Protein Name    Interleukin-18
 UniProt Synonym Protein Names   
Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma
 Protein Family    Interleukin
 UniProt Gene Name    IL18 [Similar Products]
 UniProt Synonym Gene Names    IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma [Similar Products]
 UniProt Entry Name    IL18_HUMAN
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 NCBI Summary for IL18    The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
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 UniProt Comments for IL18    IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 11q22.2-q22.3

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; regulation of cell adhesion; positive regulation of interleukin-17 production; T-helper 1 type immune response; positive regulation of natural killer cell proliferation; T-helper 2 type immune response; interleukin-2 biosynthetic process; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response
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 Research Articles on IL18    1. Alleles and genotypes of polymorphisms of IL-18, TNF-alpha and IFN-gamma are associated with a higher risk and severity of hepatocellular carcinoma (HCC) in Brazil.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL18 recombinant proteinPathways associated with IL18 recombinant protein
 Reference Product  PubMed Publications
 CASP1 recombinant protein  >473 publications with IL18 and CASP1
 IL10 recombinant protein  >283 publications with IL18 and IL10
 IL18R1 recombinant protein  >217 publications with IL18 and IL18R1
 IL13 recombinant protein  >86 publications with IL18 and IL13
 IL6 recombinant protein  >62 publications with IL18 and IL6
 IL18RAP recombinant protein  >32 publications with IL18 and IL18RAP
 IFNG recombinant protein  >21 publications with IL18 and IFNG
 IL18BP recombinant protein  >18 publications with IL18 and IL18BP
 IL1B recombinant protein  >18 publications with IL18 and IL1B
 CCR5 recombinant protein  >17 publications with IL18 and CCR5
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
Diseases associated with IL18 recombinant proteinOrgans/Tissues associated with IL18 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1119 publications with IL18 and Inflammation
 Necrosis Antibodies  >752 publications with IL18 and Necrosis
 Neoplasms Antibodies  >518 publications with IL18 and Neoplasms
 Kidney Diseases Antibodies  >276 publications with IL18 and Kidney Diseases
 Hypersensitivity Antibodies  >256 publications with IL18 and Hypersensitivity
 Nervous System Diseases Antibodies  >233 publications with IL18 and Nervous System Diseases
 Liver Diseases Antibodies  >216 publications with IL18 and Liver Diseases
 Arthritis, Rheumatoid Antibodies  >213 publications with IL18 and Arthritis, Rheumatoid
 Heart Diseases Antibodies  >188 publications with IL18 and Heart Diseases
 Hypersensitivity, Immediate Antibodies  >181 publications with IL18 and Hypersensitivity, Immediate
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >380 publications with IL18 and Liver
 Lung Antibodies  >300 publications with IL18 and Lung
 Skin Antibodies  >204 publications with IL18 and Skin
 Bone Antibodies  >203 publications with IL18 and Bone
 Heart Antibodies  >199 publications with IL18 and Heart
 Brain Antibodies  >197 publications with IL18 and Brain
 Intestine Antibodies  >149 publications with IL18 and Intestine
 Bone Marrow Antibodies  >135 publications with IL18 and Bone Marrow
 Muscle Antibodies  >123 publications with IL18 and Muscle
 Connective Tissue Antibodies  >64 publications with IL18 and Connective Tissue
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