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IL18 recombinant protein :: Interleukin-18 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203090
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-18 (IL18), Recombinant Protein

★Popular Item★
 Also Known As   

Interleukin-18, 37-193 aa, Human, E Coli (Bioactivity Validated)

 Product Synonym Names    IL18; IGIF; IL1F4; Interleukin-18; IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin; Interleukin-18; IFN gamma inducing factor; IL 1 gamma; IL 18; IL 1g; IL1 gamma; IL18 protein; IL1g; IL1gamma; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin 18; Interleukin18
 Product Gene Name   

IL18 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MYFGKLESKL SVIRNLNDQV LFIDQGNRPL FEDMTDSDCR DNAPRTIFII SMYKDSQPRG MAVTISVKCE KISTLSCENK IISFKEMNPP DNIKDTKSDI IFFQRSVPGH DNKMQFESSS YEGYFLACEK ERDLFKLILK KEDELGDRSI MFTVQNED
 OMIM    D49950 mRNA
 3D Structure    ModBase 3D Structure for Q14116
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In phosphate buffer saline (pH 7.4)
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
 Biological Activity    Measured by its ability to induce IFN-gamma secretion using KG-1 human myeloid leukemia cells in the presence of TNF-alpha. The ED50 for this effect is less or equal to 850 ng/ml.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of IL18 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL18 recombinant protein

   Interleukin 18 (IL-18), previously known as interferon-gamma (IFN-gamma)-inducing factor, is an activator of NK cells and a co-inducer of Th1 cytokines. IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IL-18 was expressed in E Coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
 Product Categories/Family for IL18 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for IL18 recombinant protein   

SDS-PAGE

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 SDS-Page of IL18 recombinant protein    IL18 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.
 NCBI GI #    4504653
 NCBI GeneID    3606
 NCBI Accession #    NP_001553 [Other Products]
 NCBI GenBank Nucleotide #    NM_001562.3 [Other Products]
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 UniProt Primary Accession #    Q14116 [Other Products]
 UniProt Secondary Accession #    O75599; Q6FGY3; Q6WWJ7 [Other Products]
 UniProt Related Accession #    Q14116 [Other Products]
 Molecular Weight    18.3kDa (158aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    interleukin-18 isoform 1
 NCBI Official Synonym Full Names    interleukin 18
 NCBI Official Symbol    IL18 [Similar Products]
 NCBI Official Synonym Symbols   
IGIF; IL-18; IL-1g; IL1F4
[Similar Products]
 NCBI Protein Information    interleukin-18
 UniProt Protein Name    Interleukin-18
 UniProt Synonym Protein Names   
Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma
 Protein Family    Interleukin
 UniProt Gene Name    IL18 [Similar Products]
 UniProt Synonym Gene Names    IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma [Similar Products]
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 NCBI Summary for IL18    The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
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 UniProt Comments for IL18    Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
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Product References and Citations for IL18 recombinant protein

   Okamura H., et al. (1995). Nature, 378, 88-91; Yoshimoto TK., et al. (1998) J. Immunol, 161, 3400-3407;
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 Research Articles on IL18    1. rs187238 was not associated with T1D in the Euro-Brazilian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL18 recombinant proteinPathways associated with IL18 recombinant protein
 Reference Product  PubMed Publications
 CASP1 recombinant protein  >766 publications with IL18 and CASP1
 IL18R1 recombinant protein  >242 publications with IL18 and IL18R1
 IL1B recombinant protein  >131 publications with IL18 and IL1B
 IL13 recombinant protein  >107 publications with IL18 and IL13
 STAT4 recombinant protein  >53 publications with IL18 and STAT4
 IL18RAP recombinant protein  >48 publications with IL18 and IL18RAP
 IFNG recombinant protein  >44 publications with IL18 and IFNG
 IL18BP recombinant protein  >22 publications with IL18 and IL18BP
 IL1A recombinant protein  >13 publications with IL18 and IL1A
 NFKB1 recombinant protein  >6 publications with IL18 and NFKB1
 Products by Pathway  Pathway Diagram
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 Corticotropin-releasing Hormone Signaling Pathway antibodies  Corticotropin-releasing Hormone Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Development And Heterogeneity Of The ILC Family Pathway antibodies  Development And Heterogeneity Of The ILC Family Pathway Diagram
Diseases associated with IL18 recombinant proteinOrgans/Tissues associated with IL18 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1708 publications with IL18 and Inflammation
 Necrosis Antibodies  >1006 publications with IL18 and Necrosis
 Disease Models, Animal Antibodies  >535 publications with IL18 and Disease Models, Animal
 Kidney Diseases Antibodies  >457 publications with IL18 and Kidney Diseases
 Hypersensitivity Antibodies  >322 publications with IL18 and Hypersensitivity
 Liver Diseases Antibodies  >313 publications with IL18 and Liver Diseases
 Heart Diseases Antibodies  >297 publications with IL18 and Heart Diseases
 Arthritis, Rheumatoid Antibodies  >256 publications with IL18 and Arthritis, Rheumatoid
 Hypersensitivity, Immediate Antibodies  >223 publications with IL18 and Hypersensitivity, Immediate
 Fibrosis Antibodies  >132 publications with IL18 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >527 publications with IL18 and Liver
 Lung Antibodies  >409 publications with IL18 and Lung
 Heart Antibodies  >327 publications with IL18 and Heart
 Brain Antibodies  >298 publications with IL18 and Brain
 Skin Antibodies  >277 publications with IL18 and Skin
 Bone Antibodies  >272 publications with IL18 and Bone
 Intestine Antibodies  >221 publications with IL18 and Intestine
 Bone Marrow Antibodies  >184 publications with IL18 and Bone Marrow
 Muscle Antibodies  >165 publications with IL18 and Muscle
 Connective Tissue Antibodies  >102 publications with IL18 and Connective Tissue
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