NP_000577
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin-2
NCBI Official Synonym Full Names
interleukin 2
NCBI Protein Information
interleukin-2
UniProt Protein Name
Interleukin-2
UniProt Synonym Protein Names
T-cell growth factor; TCGF; INN: Aldesleukin
UniProt Synonym Gene Names
NCBI Summary for IL2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
UniProt Comments for IL2
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Product References and Citations for IL2 active protein
Morgan DA., et al. (1976). Science, 193. 1007-8. ; Watson J., et al. (1980). Immunol Rev, 51. 257-78.; Taniguchi T., et al. (1983). Nature, 302. 305-10.;
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Products associated with IL2 active protein
Pathways associated with IL2 active protein
Diseases associated with IL2 active protein
Organs/Tissues associated with IL2 active protein
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