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mIL 2 recombinant protein :: Interleukin-2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143704 mIL 2 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-2 (mIL 2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Interleukin-2, His Tag

 Product Synonym Names    IL 2 Mouse, His; Interleukin-2 Mouse Recombinant, His Tag; Interleukin-2; T-cell growth factor (TCGF); Aldesleukin; Lymphokine; IL-2; Il2; mIL 2 His
 Product Gene Name   

mIL 2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAPTSSSTSS STAEAQQQQQ QQQQQQQHLE QLLMDLQELL SRMENYRNLK LPRMLTFKFY LPKQATELKD LQCLEDELGP LRHVLDLTQS KSFQLEDAEN FISNIRVTVV KLKGSDNTFE CQFDDESATV VDFLRRWIAF CQSVISTSPQ
 3D Structure    ModBase 3D Structure for P04351
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The Mouse IL2 protein (0.5mg/ml) is supplied in Phosphate Buffered Saline (pH7.4) 0.1M NaCl, and 20% glycerol.
Sterile Filtered colorless clear solution.
 Concentration    0.5mg/ml (lot specific)
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 Biological Activity    Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 2.5 ng/ml, corresponding to a specific activity of less than 400,000units/mg.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
 Other Notes    Small volumes of mIL 2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mIL 2 recombinant protein

   Description: Interleukin-2 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 170 amino acids (21-169 a.a) and having a molecular mass of 19.5kDa. The mouse IL-2 is fused to a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.

Introduction: IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
 Product Categories/Family for mIL 2 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for mIL 2. It may not necessarily be applicable to this product.
 NCBI GI #    7110653
 NCBI GeneID    16183
 NCBI Accession #    NP_032392.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008366.3 [Other Products]
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 UniProt Primary Accession #    P04351 [Other Products]
 UniProt Secondary Accession #    P97945; Q791T3 [Other Products]
 UniProt Related Accession #    P04351 [Other Products]
 Molecular Weight    19,400 Da
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 NCBI Official Full Name    interleukin-2
 NCBI Official Synonym Full Names    interleukin 2
 NCBI Official Symbol    Il2 [Similar Products]
 NCBI Official Synonym Symbols   
Il-2
[Similar Products]
 NCBI Protein Information    interleukin-2; T-cell growth factor; TCGF
 UniProt Protein Name    Interleukin-2
 UniProt Synonym Protein Names   
T-cell growth factor; TCGF
 Protein Family    Interleukin
 UniProt Gene Name    Il2 [Similar Products]
 UniProt Synonym Gene Names    Il-2; IL-2; TCGF [Similar Products]
 UniProt Entry Name    IL2_MOUSE
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 UniProt Comments for mIL 2    IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Secreted, signal peptide; Oncoprotein; Secreted; Cytokine

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding

Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; immune system process; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of T cell differentiation; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis
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 Research Articles on mIL 2    1. In mice, low-dose IL-2-anti-IL-2 antibody complexes drove group 2 innate lymphoid cells (ILC2) to produce IL-5 and proliferate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with mIL 2 recombinant proteinDiseases associated with mIL 2 recombinant protein
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >314 publications with mIL 2 and Necrosis
 Leukemia Antibodies  >229 publications with mIL 2 and Leukemia
 Inflammation Antibodies  >200 publications with mIL 2 and Inflammation
 Melanoma Antibodies  >143 publications with mIL 2 and Melanoma
 Neoplasms, Experimental Antibodies  >142 publications with mIL 2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >109 publications with mIL 2 and Kidney Diseases
 Liver Diseases Antibodies  >97 publications with mIL 2 and Liver Diseases
 HIV Infections Antibodies  >73 publications with mIL 2 and HIV Infections
 Kidney Neoplasms Antibodies  >71 publications with mIL 2 and Kidney Neoplasms
 Lung Neoplasms Antibodies  >62 publications with mIL 2 and Lung Neoplasms
Organs/Tissues associated with mIL 2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >125 publications with mIL 2 and Lymph Node
 Thymus Antibodies  >100 publications with mIL 2 and Thymus
 Brain Antibodies  >60 publications with mIL 2 and Brain
 Bladder Antibodies  >19 publications with mIL 2 and Bladder
 Embryonic Tissue Antibodies  >11 publications with mIL 2 and Embryonic Tissue
 Mammary Gland Antibodies  >3 publications with mIL 2 and Mammary Gland
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