NP_032392.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,400 Da
NCBI Official Full Name
interleukin-2
NCBI Official Synonym Full Names
interleukin 2
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-2; T-cell growth factor; TCGF
UniProt Protein Name
Interleukin-2
UniProt Synonym Protein Names
T-cell growth factor; TCGF
UniProt Synonym Gene Names
UniProt Entry Name
IL2_MOUSE
UniProt Comments for mIL 2
IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.
Protein type: Secreted, signal peptide; Oncoprotein; Secreted; Cytokine
Cellular Component: extracellular space; cell; extracellular region; cytosol
Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding
Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; immune system process; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of T cell differentiation; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis
Research Articles on mIL 2
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Pathways associated with mIL 2 active protein
Diseases associated with mIL 2 active protein
Organs/Tissues associated with mIL 2 active protein
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