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| Product Name
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Interleukin-3 (rmIL3), Recombinant Protein ★Popular Item★
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| Also Known As
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Recombinant Rhesus Macaque Interleukin-3
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| Product Synonym Names
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IL 3 Rhesus Macaque; Interleukin-3 Rhesus Macaque Recombinant; MCGF (Mast cell growth factor); Multi-CSF; HCGF; P-cell stimulation factor; IL-3; MGC79398; MGC79399
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| Sequence
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APMTQTTSLK TSWAKCSNMI DEIITHLNQP PLPSPDFNNL NEEDQTILVE KNLRRSNLEA FSKAVKSLQN ASAIESILKN LPPCLPMATA APTRPPIRIT NGDRNDFRRK LKFYLKTLEN EQAQ
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| OMIM
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147740
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| Host
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E Coli
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| Purity/Purification
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Greater than 97.0% as determined by SDS-PAGE.
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| Form/Format
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Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
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| Solubility
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It is recommended to reconstitute the lyophilized IL-3 in sterile 18MOmega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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| Biological Activity
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The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is less than 0.1ng/ml, corresponding to a Specific Activity of 10,000,000IU/mg.
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| Preparation and Storage
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Lyophilized IL-3 Rhesus Macaque although stable at room temperature for 3 weeks, should be stored dessicated below -18 degree C. Upon reconstitution IL3 Rheus Macaque should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. Please prevent freeze-thaw cycles.
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| Other Notes
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Small volumes of rmIL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Description: IL 3 Rhesus Macaque Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 124 amino acids and having a molecular mass of 14.0kDa.The IL 3 Rhesus Macaque is purified by proprietary chromatographic techniques.
Introduction: IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
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| Product Categories/Family for rmIL3 recombinant protein
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CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
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| NCBI/Uniprot data below describe general gene information for rmIL3. It may not necessarily be applicable to this product. |
| NCBI GI #
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28416915
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| NCBI GeneID
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3562
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| NCBI Accession #
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NP_000579.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_000588.3
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[Other Products]
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| UniProt Secondary Accession #
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Q6GS87
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[Other Products]
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| UniProt Related Accession #
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P08700
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[Other Products]
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| Molecular Weight
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17,233 Da
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TOP
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| NCBI Official Full Name
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interleukin-3
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| NCBI Official Synonym Full Names
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interleukin 3
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| NCBI Official Symbol
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IL3
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[Similar Products]
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| NCBI Official Synonym Symbols
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IL-3; MCGF; MULTI-CSF
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[Similar Products]
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| NCBI Protein Information
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interleukin-3; P-cell stimulating factor; P-cell-stimulating factor; colony-stimulating factor, multiple; hematopoietic growth factor; mast cell growth factor; mast-cell growth factor; multilineage-colony-stimulating factor; multipotential colony-stimulating factor
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| UniProt Protein Name
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Interleukin-3
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| UniProt Synonym Protein Names
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Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
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| Protein Family
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Interleukin
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| UniProt Gene Name
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IL3
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[Similar Products]
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| UniProt Synonym Gene Names
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IL-3; MCGF
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[Similar Products]
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| UniProt Entry Name
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IL3_HUMAN
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| NCBI Summary for rmIL3
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The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
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| UniProt Comments for rmIL3
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IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.
Protein type: Oncoprotein; Secreted; Secreted, signal peptide; Cytokine; Apoptosis; Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: extracellular space; extracellular region
Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity
Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; cell-cell signaling; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication
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| Research Articles on rmIL3
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1. Genetic variation in interleukin-3 gene is associated with breast cancer risk.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with rmIL3 recombinant protein | Pathways associated with rmIL3 recombinant protein |
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| Diseases associated with rmIL3 recombinant protein | Organs/Tissues associated with rmIL3 recombinant protein |
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Recombinant Protein 
