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IL4 recombinant protein :: Interleukin-4 protein (IL4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969289
SDS-PAGE
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $460 +1 FREE 8GB USB
0.25 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-4 protein (IL4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Interleukin-4 protein (IL4) (Active)

 Product Synonym Names    IL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
 Product Gene Name   

IL4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    25-153aa, Full Length of Mature Protein
 Sequence    HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS
 OMIM    M13982 mRNA
 3D Structure    ModBase 3D Structure for P05112
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 Host    E Coli
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 Purity/Purification    >=98% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.2 ng/ml, corresponding to a specific activity of > 5.0 106 IU/mg.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of IL4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL4 recombinant protein

   Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
 Product Categories/Family for IL4 recombinant protein    Biological Active Protein; Immunology; Interleukin
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 SDS-PAGE of IL4 recombinant protein    IL4 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for IL4. It may not necessarily be applicable to this product.
 NCBI GI #    4504669
 NCBI GeneID    3565
 NCBI Accession #    NP_000580.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000589.3 [Other Products]
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 UniProt Primary Accession #    P05112 [Other Products]
 UniProt Secondary Accession #    Q14630; Q6NZ77 [Other Products]
 UniProt Related Accession #    P05112 [Other Products]
 Molecular Weight    15.0 kDa
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 NCBI Official Full Name    interleukin-4 isoform 1
 NCBI Official Synonym Full Names    interleukin 4
 NCBI Official Symbol    IL4 [Similar Products]
 NCBI Official Synonym Symbols   
BSF1; IL-4; BCGF1; BSF-1; BCGF-1
[Similar Products]
 NCBI Protein Information    interleukin-4
 UniProt Protein Name    Interleukin-4
 UniProt Synonym Protein Names   
B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
 Protein Family    Interleukin
 UniProt Gene Name    IL4 [Similar Products]
 UniProt Synonym Gene Names    IL-4; BSF-1 [Similar Products]
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 NCBI Summary for IL4    The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL4    IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular region; extracellular space

Molecular Function: interleukin-4 receptor binding; protein binding

Biological Process: B cell differentiation; cellular defense response; chemotaxis; cholesterol metabolic process; connective tissue growth factor biosynthetic process; immune response; myeloid dendritic cell differentiation; negative regulation of apoptosis; negative regulation of osteoclast differentiation; negative regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of MHC class II biosynthetic process; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of immune response; regulation of isotype switching; regulation of phosphorylation; T-helper 2 type immune response

Disease: Stroke, Ischemic
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 Research Articles on IL4    1. Our results showed the role of IL4 in promoting breast cancer aggressiveness
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL4 recombinant proteinPathways associated with IL4 recombinant protein
 Reference Product  PubMed Publications
 IL5 recombinant protein  >234 publications with IL4 and IL5
 STAT6 recombinant protein  >122 publications with IL4 and STAT6
 IL4R recombinant protein  >79 publications with IL4 and IL4R
 CSF2 recombinant protein  >19 publications with IL4 and CSF2
 IL13RA1 recombinant protein  >16 publications with IL4 and IL13RA1
 JAK2 recombinant protein  >12 publications with IL4 and JAK2
 JAK3 recombinant protein  >8 publications with IL4 and JAK3
 IL2RG recombinant protein  >5 publications with IL4 and IL2RG
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
Diseases associated with IL4 recombinant proteinOrgans/Tissues associated with IL4 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >416 publications with IL4 and Inflammation
 Necrosis Antibodies  >378 publications with IL4 and Necrosis
 Hypersensitivity Antibodies  >374 publications with IL4 and Hypersensitivity
 Hypersensitivity, Immediate Antibodies  >304 publications with IL4 and Hypersensitivity, Immediate
 Asthma Antibodies  >267 publications with IL4 and Asthma
 Lung Diseases Antibodies  >250 publications with IL4 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >227 publications with IL4 and Respiratory Hypersensitivity
 Autoimmune Diseases Antibodies  >190 publications with IL4 and Autoimmune Diseases
 Liver Diseases Antibodies  >67 publications with IL4 and Liver Diseases
 Dermatitis, Atopic Antibodies  >59 publications with IL4 and Dermatitis, Atopic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1445 publications with IL4 and Blood
 Spleen Antibodies  >107 publications with IL4 and Spleen
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