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IL 5 recombinant protein :: Interleukin-5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142089 IL 5 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,760 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-5 (IL 5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Interleukin-5

 Product Synonym Names    IL 5 Human; Interleukin-5 Human Recombinant; EDF; BCDFII; TRF; T-cell replacing factor; Eosinophil differentiation factor; B cell differentiation factor I; IL-5
 Product Gene Name   

IL 5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ile-Pr o-Thr-Glu
 OMIM    147850
 3D Structure    ModBase 3D Structure for P05113
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Interleikin-5 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50 as determined by the dose-dependant stimulation of the proliferation of TF-1 cells was found to be < 0.15ng/ml, corresponding to a Specific Activity of 6 x 106 IU/mg.
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 Preparation and Storage    Lyophilized Interleukin-5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please avoid freeze thaw cycles.
 Other Notes    Small volumes of IL 5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL 5 recombinant protein

   Description: Interleukin-5 Human Recombinant produced in E Coli is a dimeric, non-glycosylated polypeptide chain containing two 113 amino acids chains, and having a molecular mass of 26522.84 Dalton. The IL-5 is purified by proprietary chromatographic techniques.

Introduction: The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
 Product Categories/Family for IL 5 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for IL 5. It may not necessarily be applicable to this product.
 NCBI GI #    4504671
 NCBI GeneID    3567
 NCBI Accession #    NP_000870.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000879.2 [Other Products]
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 UniProt Primary Accession #    P05113 [Other Products]
 UniProt Secondary Accession #    Q13840 [Other Products]
 UniProt Related Accession #    P05113 [Other Products]
 Molecular Weight    15,238 Da
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 NCBI Official Full Name    interleukin-5
 NCBI Official Synonym Full Names    interleukin 5
 NCBI Official Symbol    IL5 [Similar Products]
 NCBI Official Synonym Symbols   
EDF; TRF; IL-5
[Similar Products]
 NCBI Protein Information    interleukin-5; B-cell differentiation factor I; T-cell replacing factor; colony-stimulating factor, eosinophil; eosinophil differentiation factor
 UniProt Protein Name    Interleukin-5
 UniProt Synonym Protein Names   
B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF
 Protein Family    Interleukin
 UniProt Gene Name    IL5 [Similar Products]
 UniProt Synonym Gene Names    IL-5; TRF [Similar Products]
 UniProt Entry Name    IL5_HUMAN
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 NCBI Summary for IL 5    This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
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 UniProt Comments for IL 5    IL5: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. Belongs to the IL-5 family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; interleukin-5 receptor binding; growth factor activity; cytokine activity

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of transcription factor activity; immune response; positive regulation of immunoglobulin secretion; inflammatory response; positive regulation of eosinophil differentiation
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 Research Articles on IL 5    1. HDM-specific IL-5 responses at age 3 years or later are the best measure of T cell function for predicting asthma at age 8 years.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL 5 recombinant proteinPathways associated with IL 5 recombinant protein
 Reference Product  PubMed Publications
 IL4 recombinant protein  >216 publications with IL 5 and IL4
 IL2 recombinant protein  >101 publications with IL 5 and IL2
 IL3 recombinant protein  >50 publications with IL 5 and IL3
 JUN recombinant protein  >37 publications with IL 5 and JUN
 IL9 recombinant protein  >25 publications with IL 5 and IL9
 IL5RA recombinant protein  >24 publications with IL 5 and IL5RA
 CSF2RB recombinant protein  >5 publications with IL 5 and CSF2RB
 SDCBP recombinant protein  >1 publications with IL 5 and SDCBP
 FOS recombinant protein  >1 publications with IL 5 and FOS
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with IL 5 recombinant proteinOrgans/Tissues associated with IL 5 recombinant protein
 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >133 publications with IL 5 and Hypersensitivity
 Asthma Antibodies  >114 publications with IL 5 and Asthma
 Inflammation Antibodies  >111 publications with IL 5 and Inflammation
 Lung Diseases Antibodies  >88 publications with IL 5 and Lung Diseases
 Eosinophilia Antibodies  >71 publications with IL 5 and Eosinophilia
 Necrosis Antibodies  >61 publications with IL 5 and Necrosis
 Drug Hypersensitivity Antibodies  >18 publications with IL 5 and Drug Hypersensitivity
 Bronchial Hyperreactivity Antibodies  >13 publications with IL 5 and Bronchial Hyperreactivity
 Fibrosis Antibodies  >13 publications with IL 5 and Fibrosis
 Hyperplasia Antibodies  >10 publications with IL 5 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >8 publications with IL 5 and Thymus
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