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IL 7 recombinant protein :: Interleukin-7 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142175 IL 7 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,585 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-7 (IL 7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Interleukin-7, Saccharomyces

 Product Synonym Names    IL 7 Human, Yeast; Interleukin-7 Human Recombinant, Yeast; Lymphopoietin 1 (LP-1); pre-B cell factor; IL-7; IL 7 Yeast
 Product Gene Name   

IL 7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Asp-Cys-As p-Ile-Glu
 OMIM    146660
 3D Structure    ModBase 3D Structure for P13232
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 Host    Saccharomyces cerevisiae
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 Purity/Purification    Greater than 98.0% as determined by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution in water containing 20mM phosphate buffer.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Interleukin -7 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.418 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-7 as a Reference Standard.
 Biological Activity    The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine pre-B cell line 2E8 is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.
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 Preparation and Storage    Lyophilized Interleukin-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL7 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of IL 7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL 7 recombinant protein

   Description: Interleukin-7 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 152 amino acids and having a molecular mass of 17.4 kDa. The IL-7 is purified by proprietary chromatographic techniques.

Introduction: IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.
 Product Categories/Family for IL 7 recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin
NCBI/Uniprot data below describe general gene information for IL 7. It may not necessarily be applicable to this product.
 NCBI GI #    4504677
 NCBI GeneID    3574
 NCBI Accession #    NP_000871.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000880.3 [Other Products]
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 UniProt Primary Accession #    P13232 [Other Products]
 UniProt Secondary Accession #    Q5FBY5; Q5FBY9; A0N0L3 [Other Products]
 UniProt Related Accession #    P13232 [Other Products]
 Molecular Weight    7,687 Da
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 NCBI Official Full Name    interleukin-7 isoform 1
 NCBI Official Synonym Full Names    interleukin 7
 NCBI Official Symbol    IL7 [Similar Products]
 NCBI Official Synonym Symbols   
IL-7
[Similar Products]
 NCBI Protein Information    interleukin-7
 UniProt Protein Name    Interleukin-7
 Protein Family    Interleukin
 UniProt Gene Name    IL7 [Similar Products]
 UniProt Synonym Gene Names    IL-7 [Similar Products]
 UniProt Entry Name    IL7_HUMAN
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 NCBI Summary for IL 7    The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
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 UniProt Comments for IL 7    IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Secreted, signal peptide; Secreted; Cytokine; Cell development/differentiation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity

Biological Process: positive regulation of organ growth; humoral immune response; organ morphogenesis; T cell lineage commitment; cell-cell signaling; positive regulation of T cell differentiation; homeostasis of number of cells within a tissue; regulation of gene expression; negative regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of apoptosis; bone resorption
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 Research Articles on IL 7    1. These results strongly suggest that IL-7/IL-7R prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL 7 recombinant proteinPathways associated with IL 7 recombinant protein
 Reference Product  PubMed Publications
 IL7R recombinant protein  >13 publications with IL 7 and IL7R
 IL3 recombinant protein  >10 publications with IL 7 and IL3
 IL2RG recombinant protein  >10 publications with IL 7 and IL2RG
 IL2RA recombinant protein  >9 publications with IL 7 and IL2RA
 JAK3 recombinant protein  >9 publications with IL 7 and JAK3
 FOXP3 recombinant protein  >7 publications with IL 7 and FOXP3
 IL9 recombinant protein  >7 publications with IL 7 and IL9
 CSF2 recombinant protein  >4 publications with IL 7 and CSF2
 JAK1 recombinant protein  >4 publications with IL 7 and JAK1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-7 Signaling Pathway antibodies  Interleukin-7 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with IL 7 recombinant proteinOrgans/Tissues associated with IL 7 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with IL 7 and Inflammation
 Necrosis Antibodies  >21 publications with IL 7 and Necrosis
 Multiple Sclerosis Antibodies  >19 publications with IL 7 and Multiple Sclerosis
 Lymphopenia Antibodies  >17 publications with IL 7 and Lymphopenia
 Neoplasms, Experimental Antibodies  >15 publications with IL 7 and Neoplasms, Experimental
 Death Antibodies  >14 publications with IL 7 and Death
 Carcinoma Antibodies  >11 publications with IL 7 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >7 publications with IL 7 and Cell Transformation, Neoplastic
 Sepsis Antibodies  >6 publications with IL 7 and Sepsis
 Hypersensitivity Antibodies  >6 publications with IL 7 and Hypersensitivity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >212 publications with IL 7 and Blood
 Bone Antibodies  >50 publications with IL 7 and Bone
 Thymus Antibodies  >40 publications with IL 7 and Thymus
 Lymph Node Antibodies  >20 publications with IL 7 and Lymph Node
 Skin Antibodies  >14 publications with IL 7 and Skin
 Spleen Antibodies  >12 publications with IL 7 and Spleen
 Liver Antibodies  >10 publications with IL 7 and Liver
 Brain Antibodies  >9 publications with IL 7 and Brain
 Intestine Antibodies  >8 publications with IL 7 and Intestine
 Kidney Antibodies  >5 publications with IL 7 and Kidney
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