Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow rmIL8  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ERp31 Antibody
 • Fibroblast Growth Factor Receptor 1 (FGFR1) Recombinant Protein
 • Troponin I (TNNI2) Antibody
 • hCG beta Antibody
 • SNCG (SNCG ) Antibody
 • Retinoschisin (RS1) Antibody
 • Oxycodone Antibody
 • Axin-1 (AXIN1) ELISA Kit
 • FK506 Binding Protein 7 (FKBP7) Antibody
 • CA 19-9 Native Protein
 • MDA ELISA Kit
 • Galectin-9 (LGALS9) Antibody
 • T-cell surface glycoprotein CD8 beta chain (CD8B) Recombinant Protein
 • Total Cholesterol Assay Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

rmIL8 recombinant protein :: Interleukin-8 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144659 rmIL8 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-8 (rmIL8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rhesus Macaque Interleukin-8

 Product Synonym Names    IL 8 Rhesus Macaque; Interleukin-8 Rhesus Macaque Recombinant; IL-8; CXCL8; Monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil-activating peptide; MONAP; Emoctakin; K60; NAF; LECT; LUCT; 3-10C; LYNAP; SCYB8; TSG-1; AMCF-I; b-ENAP
 Product Gene Name   

rmIL8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    AVLPRSAKEL RCECIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE PWVQRVVEKF VKRAENQNP
 OMIM    146930
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 97.0% as determined by SDS-PAGE.
 Form/Format    Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Section Bar
 Solubility    It is recommended to reconstitute the lyophilized IL-8 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 50-150ng/ml, corresponding to a Specific Activity of 6,667-20,000IU/mg.
Section Bar
 Other Notes    Small volumes of rmIL8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for rmIL8 recombinant protein

   Description: IL 8 Rhesus Macaque Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.The IL 8 Rhesus Macaque is purified by proprietary chromatographic techniques.

Introduction: Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies.When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.
 Product Categories/Family for rmIL8 recombinant protein    CHEMOKINES; Chemokines; Interleukin-8 (CXCL8)
NCBI/Uniprot data below describe general gene information for rmIL8. It may not necessarily be applicable to this product.
 NCBI GI #    10834978
 NCBI GeneID    3576
 NCBI Accession #    NP_000575.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000584.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q6FGF6; Q6LAE6; Q96RG6; Q9C077; Q9UCE1; Q9UCR8; Q9UCR9; Q9UCS0; B2R4L8 [Other Products]
 UniProt Related Accession #    P10145 [Other Products]
 Molecular Weight    11,338 Da
Table BarTOPTable Bar
 NCBI Official Full Name    interleukin-8
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 8
 NCBI Official Symbol    CXCL8 [Similar Products]
 NCBI Official Synonym Symbols   
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
[Similar Products]
 NCBI Protein Information    interleukin-8; T-cell chemotactic factor; alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; emoctakin; granulocyte chemotactic protein 1; interleukin 8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; tumor necrosis factor-induced gene 1
 UniProt Protein Name    Interleukin-8
 UniProt Synonym Protein Names   
C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factorCleaved into the following 7 chains:MDNCF-aAlternative name(s):GCP/IL-8 protein IV; IL8/NAP1 form I
 Protein Family    Interleukin
 UniProt Gene Name    CXCL8 [Similar Products]
 UniProt Synonym Gene Names    IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF [Similar Products]
 UniProt Entry Name    IL8_HUMAN
Section Bar
 NCBI Summary for rmIL8    The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for rmIL8    IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13-q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; interleukin-8 receptor binding

Biological Process: regulation of cell adhesion; neutrophil chemotaxis; neutrophil activation; unfolded protein response; negative regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; chemotaxis; signal transduction; regulation of retroviral genome replication; induction of positive chemotaxis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; response to molecule of bacterial origin; receptor internalization; immune response; angiogenesis; cell cycle arrest; inflammatory response; cell motility; embryonic gut development
Table BarTOPTable Bar
 Research Articles on rmIL8    1. In endometriosis, TSLP is involved in estrogen mediated regulation of the secretion of MCP-1 and IL-8, and the growth of endometrial stromal cells through JNK and NF-kappaB signal pathways.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with rmIL8 recombinant proteinDiseases associated with rmIL8 recombinant protein
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >628 publications with rmIL8 and Inflammation
 Necrosis Antibodies  >317 publications with rmIL8 and Necrosis
 Pulmonary Disease, Chronic Obstructive Antibodies  >81 publications with rmIL8 and Pulmonary Disease, Chronic Obstructive
 Adenocarcinoma Antibodies  >34 publications with rmIL8 and Adenocarcinoma
 Breast Neoplasms Antibodies  >27 publications with rmIL8 and Breast Neoplasms
 Kidney Diseases Antibodies  >20 publications with rmIL8 and Kidney Diseases
 Colorectal Neoplasms Antibodies  >15 publications with rmIL8 and Colorectal Neoplasms
 Pulmonary Fibrosis Antibodies  >15 publications with rmIL8 and Pulmonary Fibrosis
 Fever Antibodies  >14 publications with rmIL8 and Fever
 Prostatic Neoplasms Antibodies  >14 publications with rmIL8 and Prostatic Neoplasms
Organs/Tissues associated with rmIL8 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >755 publications with rmIL8 and Blood
 Lung Antibodies  >247 publications with rmIL8 and Lung
 Vascular Antibodies  >201 publications with rmIL8 and Vascular
 Skin Antibodies  >123 publications with rmIL8 and Skin
 Bone Antibodies  >69 publications with rmIL8 and Bone
 Brain Antibodies  >58 publications with rmIL8 and Brain
 Muscle Antibodies  >55 publications with rmIL8 and Muscle
 Intestine Antibodies  >52 publications with rmIL8 and Intestine
 Heart Antibodies  >51 publications with rmIL8 and Heart
 Bone Marrow Antibodies  >47 publications with rmIL8 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions